Yıl: 2007 Cilt: 13 Sayı: 2 Sayfa Aralığı: 37 - 43 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3)

Öz:
Aim: The aim of this study was to determine whether circulating levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were associated with bone mineral density (BMD) and bone turnover markers in middle aged Turkish males. Patients and Methods: At the beginning, a total of 160 Turkish men aged between 35 and 65 years were included to this study. The final sample comprised of 112 men because 48 men were excluded from the study. BMD of the spine and the hip was measured with dual energy x-ray absorptiometry. After an overnight fasting, serum IGF-1, IGFBP-3, intact parathyroid hormone, 25-hydroxy vitamin D, osteocalcin, C-terminal telopeptide, calcium, phosphorous and alkaline phosphatase levels were measured. Urinary concentrations of calcium, phosphorous and creatinine were also estimated.Results: Twenty-one men (18.8%) had a bone mineral density of ≤ -2.5 SD (T score). There was a significant difference in IGF-1 levels between men with normal BMD and men with reduced BMD (132.5 ± 38.1 and 116.1 ± 40.6 respectively and p: 0.04). Serum IGF-1 levels were positively correlated with BMD of the lumbar spine (r: 0.28, p:0.006), but there was no correlation between IGFBP-3 and BMD of any sites tested. IGF-1, IGFBP-3 and BMD were not correlated with bone turnover markers except serum alkaline phosphatase level. Conclusion: Serum IGF-1 levels were lower in men with reduced BMD and positively correlated with BMD of the lumbar spine. Neither IGF-1 nor IGFBP-3 was correlated with bone turnover markers. Further studies of these factors in skeletal cells are needed to explain their role in the pathophysiology of idiopathic male osteoporosis. (From the World of Osteoporosis 2007;13:37-43)
Anahtar Kelime: Male Middle Aged Insulin-Like Growth Factor Binding Protein 3 Absorptiometry, Photon Osteoporosis Bone Density Insulin-Like Growth Factor I

Konular: Genel ve Dahili Tıp

Orta yaşlı Türk erkeklerinde serum IGF-1 ve IGFBP-3 seviyeleri: Kemik mineral yoğunluğu ve kemik yapım-yıkım belirteçleri ile ilişkileri (erkek osteoporuzu & IGF-1, IGFBP-3)

Öz:
Amaç: Bu çalışmanın amacı orta yaşlı Türk erkeklerinde serum insulin benzeri büyüme faktörü-1 (IGF-1) ve insulin benzeri büyüme faktörü bağlayıcı protein-3 (IGFBP-3)’ün kemik mineral yoğunluğu ve kemik yapım yıkım belirteçleri ile ilişkili olup olmadığını göstermekti. Hastalar ve Yöntem: Başlangıçta bu çalışmaya 35 ile 65 yaşları arasında 160 Türk erkeği dahil edildi. Daha sonra 48 hasta çalışma dışı bırakıldığı için son örneklem 112 erkeği içerdi. Omurga ve kalçanın kemik mineral yoğunluğu (KMY) dual enerji x-ray absorptiometri ile ölçüldü. Bir gecelik açlık sonrası, serum IGF-1, IGFBP-3, intakt parathormon, 25-OH vitamin D, osteokalsin, C-terminal telopeptid, kalsiyum, fosfor, ve alkalen fosfataz seviyeleri ölçüldü. Kalsiyum, fosfor ve kreatininnin idrar konsantrasyonları da tesbit edildi. Bulgular: Yirmi bir erkekde (% 18.8) kemik mineral yoğunluğu T skoru -2.5 SD’a eşit veya altında idi. Normal ve azalmış KMY’si olan hastalar arasında IGF-1 düzeylerinde anlamlı farklılık vardı (sırasıyla 132.5 ± 38.1 ve 116.1 ± 40.6, p: 0.04). Serum IGF-1 düzeyleri lomber omurganın KMY’si ile pozitif korele idi. Fakat, IGFBP-3 ve test edilen yerlerin hiçbirinin KMY’si arasında korelasyon yoktu. IGF-1, IGFBP-3 ve KMY serum alkalen fosfatazı hariç kemik yapım yıkım belirteçleri korele değildi. Sonuçlar: Serum IGF-1 seviyeleri KMY’si azalmış olan erkelerde daha düşüktü ve lomber omurganın KMY’si ile pozitif olarak korele idi. Ne IGF-1 ne de IGFBP-3 kemik yapım yıkım belirteçleri ile korele değildi. İskelet hücrelerindeki bu faktörlerin, idiopatik erkek osteoporozunun patofizyolojisindeki rolünü açıklamak için ek çalışmalara gereksinim vardır. (Osteoporoz Dünyasından 2007;13:37-43)
Anahtar Kelime: Kemik yoğunluğu İnsülin-benzeri büyüme faktörü I Erkek Orta yaşlı İnsülin-benzeri büyüme faktörü bağlayıcı protein 3 Absorptiyometri, foton Osteoporoz

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Jackson JA, Kleerekoper M. Osteoporosis in men: diagnosis, pathophysiology and prevention. Medicine 1990;69:137-52.
  • 2. Orwoll ES, Klein RF. Osteoporosis in men. Endocr Rev 1995;16:87-115.
  • 3. Khosla S, Lufkin EG, Hodgson SF, Fitzpatrick LA, Melton LJ. Epidemiology and clinical features of osteoporosis in young individuals. Bone 1994;15:551-5.
  • 4. Seeman E. The dilemma of osteoporosis in men. Am J Med 1995;98 (Supp) 2A:76-88.
  • 5. Kelepouris N, Harper K, Gannon F, Kaplan F, Haddad JG. Severe osteoporosis in men. Ann Intern Med 1995;123:452-60.
  • 6. Kurland ES, Rosen CF, Comsan F, Mcmahon D, Chan F, Shane E, et al. Insulin like growth factor-1 in men with idiopathic osteoporosis. Journal of Clinical Endocrinology and Metabolism 1997;82:2799-805.
  • 7. Ohlsson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC. Growth hormone and bone. Endocrine Reviews 1998;19:55-79.
  • 8. Russell-Aulet M, Shapiro B, Jaffe CA, Gross MD, Barkan AL. Peak bone mass in young healthy men is correlated with the magnitude of endogenous growth hormone secretion. Journal of Clinical Endocrinology and Metabolism 1998;83:3463-8.
  • 9. Krasik D, Rosen CJ, Hannan MT, Broe KE, Dawson Hughes D, Gagnon DR, et al. Insulin like growth factor binding proteins 4 and 5 and bone mineral density in elderly men and women. Calcif Tissue Int 2002;71:323-8.
  • 10. Hock JM, Centrella M, Canalis E. Insulin- like growth factor 1 has independent effects on bone matrix formation and cell replication. Endocrinology 1988;122:254-60.
  • 11. Marcelli C, Yates AJ, Mundy GR. In vivo effects of human recombinant transforming growth factor beta on bone turnover in normal mice. Journal of Bone Mineral Research 1990;5:1087-96.
  • 12. Baxter RC. Circulating binding proteins for the insulin-like growth factors. Trends Endocrinol Metab 1993;4:91-6.
  • 13. Corpas E, Harman SM, Blackman MR. Serum IGF-binding protein-3 is related to IGF-1, but not to spontaneous GH release, in healthy old men. Horm Metab Res 1992;24:543-5.
  • 14. Conover CA. Glycosylation of insulin-like growth factor binding protein-3 (IGFBP-3) is not required for potentiation of IGF-1 action: Evidence for processing of cell-bound IGFBP-3. Endocrinology 1992;129:3259-68.
  • 15. Barrett-Connor E, Goodman-Gruen D. Gender differences in insulin like growth factor and bone mineral density association in old age: the Rancho Bernardo study. J Bone Miner Res 1998;13:1343-9.
  • 16. Langlois JA, Rosen CJ, Visser M, Hannan MT, Harris T, Wilson PWF, et al. Association between insulin-like growth factor 1 and bone mineral density in older women and men: the Framingham Heart Study. J Clin Endocrinol Metab 1998;83:4257-62.
  • 17. Center JR, Nguyen TV, Sambrook PN, Eisman JA. Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab 1999;84:3626-35.
  • 18. Johansson AG, Forslund A, Hambraeus L, Blum WF, Ljunghall S. Growth hormone dependent insulin- like growth factor binding protein is a major determinant of bone mineral density in healthy men. J Bone Miner Res 1994;9:915-21.
  • 19. Gillberg P, Olofsson H, Mallmin H, Blum WF, Ljunghall S, Nilsson AG. Bone mineral density in femoral neck is positively correlated to circulating insulin-like growth factor (IGF-1) and IGF-binding protein (IGFBP)-3 in Swedish men. Calcif Tissue Int 2002;70:22-9.
  • 20. Szulc P, Joly Pharaboz MO, Marchand F, Delmas PD. Insulin like growth factor 1 is a determinant of hip bone mineral density in men less than 60 years of age: MINOS study. Calcif Tissue Int 2004:74:322-9.
  • 21. Sugimoto T, Nishiyama K, Kuribayashi F, Chihara K. Serum levels of insulin-like growth factor (IGF) 1, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures. J Bone Miner Res 1997;12:1272-9.
  • 22. Pfeilschifter J, Scheidt-Nave C, Leidig-Bruckner G, Woitge HW, Blum WF, Wuster C, et al. Relationship between circulating insulin like growth factor components and sex hormones in a population-based sample of 50 to 80 year old men and women. J Clin Endocrinol Metab 1996;81:2534-40.
  • 23. Amin S, Lawrence Riggs B, Atkinson EJ, Oberg AL, Melton LJ, Khosla S. A potentially deleterious role of IGFBP-2 on bone density in aging men and women. Journal of Bone and Mineral Research 2004;19:1075-83.
  • 24. Bilezikian JP. Osteoporosis in men. J Clin Endocrinol Metab 1999;84:3431-4.
  • 25. Kanis JL, Melton LS, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res 1994;9:1137-41.
  • 26. Reed BY, Zerwekh JE, Sakhaee K, Breslau NA, Gottschalk F, Pak CYC. Serum IGF-1 is low and correlated with osteoblastic surface in idiopathic osteoporosis. J Bone Miner Res 1995; 10:1218-24.
  • 27. Ljunghall S, Johansson AG, Burnan P, Kampe O, Lindh E, Karlsson FA. Low plasma levels of insulin like growth factor 1 (IGF) in male patients with idiopathic osteoporosis. J Intern Med 1992;232:59
  • 28. Janssen JA, Burger H, Stolk RP, Grobbee DE, de Jong FH, Lamberts SW, et al. Gender –specific relationship between serum free and total IGF-1 and bone mineral density in elderly men and women. Eur J Endocrinol 1998;138:627-32.
  • 29. Krassas GE, Papadopoulou PH, Koliakos G. Growth hormone, insulin growth factor-1, and IGF binding protein-3 axis relationship with bone mineral density among healthy men. Archives of Andrology 2003;49:191-9.
  • 30. Gürlek A, Gedik O. Endogenous sex steroid, GH and IGF-1 levels in normal elderly men: Relationship with bone mineral density and markers of bone tornover. J Endocrinol Invest 2001;24:408-14.
  • 31. Johansson AG, Eriksen EF, Lindh E, Langdahl B, Blum WF, Lindahl A, et al. Reduced serum levels of the growth hormone-dependent insulin like growth factor binding protein and a negative bone balance at the level of individual remodeling units in idiopathic osteoporosis in men. J Clin Endocrinol Metab 1997;82:2795-8.
  • 32. Rucker D, Ezzat S, Diamandi A, Khosravi J, Hanley DA. IGF-1 and testosterone levels as predictors of bone mineral density in healthy, community-dwelling men. Clinical Endocrinology 2004;60:491-9.
APA sezgin m, ÇİMEN B, KANIK A, AS İ, ERÇETİN N, arinci Incel N, ŞAHİN G (2007). Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). , 37 - 43.
Chicago sezgin melek,ÇİMEN Burak,KANIK Arzu,AS İsmet,ERÇETİN Neslihan,arinci Incel Nurgül,ŞAHİN Günşah Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). (2007): 37 - 43.
MLA sezgin melek,ÇİMEN Burak,KANIK Arzu,AS İsmet,ERÇETİN Neslihan,arinci Incel Nurgül,ŞAHİN Günşah Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). , 2007, ss.37 - 43.
AMA sezgin m,ÇİMEN B,KANIK A,AS İ,ERÇETİN N,arinci Incel N,ŞAHİN G Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). . 2007; 37 - 43.
Vancouver sezgin m,ÇİMEN B,KANIK A,AS İ,ERÇETİN N,arinci Incel N,ŞAHİN G Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). . 2007; 37 - 43.
IEEE sezgin m,ÇİMEN B,KANIK A,AS İ,ERÇETİN N,arinci Incel N,ŞAHİN G "Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3)." , ss.37 - 43, 2007.
ISNAD sezgin, melek vd. "Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3)". (2007), 37-43.
APA sezgin m, ÇİMEN B, KANIK A, AS İ, ERÇETİN N, arinci Incel N, ŞAHİN G (2007). Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). Osteoporoz Dünyasından, 13(2), 37 - 43.
Chicago sezgin melek,ÇİMEN Burak,KANIK Arzu,AS İsmet,ERÇETİN Neslihan,arinci Incel Nurgül,ŞAHİN Günşah Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). Osteoporoz Dünyasından 13, no.2 (2007): 37 - 43.
MLA sezgin melek,ÇİMEN Burak,KANIK Arzu,AS İsmet,ERÇETİN Neslihan,arinci Incel Nurgül,ŞAHİN Günşah Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). Osteoporoz Dünyasından, vol.13, no.2, 2007, ss.37 - 43.
AMA sezgin m,ÇİMEN B,KANIK A,AS İ,ERÇETİN N,arinci Incel N,ŞAHİN G Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). Osteoporoz Dünyasından. 2007; 13(2): 37 - 43.
Vancouver sezgin m,ÇİMEN B,KANIK A,AS İ,ERÇETİN N,arinci Incel N,ŞAHİN G Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3). Osteoporoz Dünyasından. 2007; 13(2): 37 - 43.
IEEE sezgin m,ÇİMEN B,KANIK A,AS İ,ERÇETİN N,arinci Incel N,ŞAHİN G "Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3)." Osteoporoz Dünyasından, 13, ss.37 - 43, 2007.
ISNAD sezgin, melek vd. "Serum IGF-1 and IGFBP-3 levels in middle aged Turkish males: Relationships with bone mineral density and markers of bone turnover (male osteoporosis & IGF-1, IGFBP-3)". Osteoporoz Dünyasından 13/2 (2007), 37-43.