The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients

GÜLYAŞAR, Tevfik; ÖZKEÇECİ, Ercüment; ŞENER, Serap

The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients

Ercüment ÖZKEÇECİ, (Trakya Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Edirne, Türkiye)

Tevfik GÜLYAŞAR, (Trakya Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Edirne, Türkiye)

Serap ŞENER (Trakya Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Edirne, Türkiye)

Trakya Üniversitesi Tıp Fakültesi Dergisi

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Yıl: 2008 Cilt: 25 Sayı: 2 Sayfa Aralığı: 100 - 104 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients

Öz:

Amaç: G proteini beta-3 (β3) altbirimini (GNB3) kodlayan genin C825T polimorfizmi G proteinleri yoluyla sinyal iletiminde artışla ve sonuçta artmış Na+/H+ değiştiricisinin aktivitesi ile ilişkilidir. Bu iyon taşıma sistemi proksimal tübülden sodyum geri emilimine aracılık eder. Değişik nüfuslardan hipertansif hastaların hücrelerinde Na+/H+ değiştiricisinin aktivitesinde artış bulunmuştur. Bu çalışmada hipertansiyonlu Türk hasta grubunda bu polimorfizm araştırıldı ve normotansif bireylerle karşılaştırıldı. Hastalar ve Yöntemler: Doksan dokuz hipertansif hasta (57 erkek, 42 kadın) ve 45 normotansif kontrolde (33 erkek, 12 kadın) GNB3 C825T polimorfizmi için genotipleme yapıldı.Bulgular: Hasta ve kontrol gruplarında alel dağılımı sırasıyla CC:35, CT:51, TT:13 ve CC:26, CT:15, TT:4 şeklindeydi. T aleli taşıyıcıları (CT ve TT) hipertansiyonlu grupta anlamlı şekilde daha yüksekti. Hipertansiyon ve C825T aleli arasında istatistiksel bakımdan anlamlı ilişki (Ki-kare testi, p=0.041) bulundu.Sonuç: Bu bulgular Türk hastalarda hipertansiyon ve GNB3 polimorfizminin ilişkili olduğunu ve artmış G proteini aktivitesinin C825T ile hipertansiyon arasındaki patofizyolojik bağlantı olabileceğini düşündürmektedir.

Anahtar Kelime: Türk toplumu Genotiplendirme teknikleri GTP-bağlayıcı proteinler Polimorfizm, genetik Hipertansiyon

Konular: Genel ve Dahili Tıp

Hipertansiyonlu Türk hasta grubunda hipertansiyon ile G proteini beta-3 altbirimini kodlayan gende C825T polimorfizmi arasındaki ilişki

Öz:

Objectives: The C825T polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) is associated with enhanced signal transduction via G proteins which in turn results in an increased Na+/H+ exchanger activity. This ion transport system mediates sodium reabsorption in the proximal tubule. Increased activity of Na+/H+ exchanger was found in the cells of patients with arterial hypertension in different populations. We investigated this polymorphism in a Turkish group of patients with hypertension and compared them with normotensive subjects. Patients and Methods: 99 hypertensive patients (57 males, 42 females) and 45 normotensive controls (33 males, 12 females) were genotyped for the GNB3 C825T polymorphism.Results: Allele distribution of patient and control groups were CC: 35, CT: 51, TT: 13 and CC: 26, CT: 15, TT: 4, respectively. T-allele carriers (CT and TT) were significantly higher in hypertensive group. There was also a statistically significant (Chi-square test, p=0.041) relationship between 825T allele and hypertension.Conclusion: These results suggest that hypertension is related with GNB3 polymorphism in Turkish patients and increased G protein activity may be the pathophysiologic link between C825T and hypertension.

Anahtar Kelime: Polymorphism, Genetic Hypertension Turkish population Genotyping Techniques GTP-Binding Proteins

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZKEÇECİ E, GÜLYAŞAR T, ŞENER S (2008). The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. , 100 - 104.
Chicago	ÖZKEÇECİ Ercüment,GÜLYAŞAR Tevfik,ŞENER Serap The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. (2008): 100 - 104.
MLA	ÖZKEÇECİ Ercüment,GÜLYAŞAR Tevfik,ŞENER Serap The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. , 2008, ss.100 - 104.
AMA	ÖZKEÇECİ E,GÜLYAŞAR T,ŞENER S The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. . 2008; 100 - 104.
Vancouver	ÖZKEÇECİ E,GÜLYAŞAR T,ŞENER S The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. . 2008; 100 - 104.
IEEE	ÖZKEÇECİ E,GÜLYAŞAR T,ŞENER S "The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients." , ss.100 - 104, 2008.
ISNAD	ÖZKEÇECİ, Ercüment vd. "The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients". (2008), 100-104.

APA	ÖZKEÇECİ E, GÜLYAŞAR T, ŞENER S (2008). The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. Trakya Üniversitesi Tıp Fakültesi Dergisi, 25(2), 100 - 104.
Chicago	ÖZKEÇECİ Ercüment,GÜLYAŞAR Tevfik,ŞENER Serap The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. Trakya Üniversitesi Tıp Fakültesi Dergisi 25, no.2 (2008): 100 - 104.
MLA	ÖZKEÇECİ Ercüment,GÜLYAŞAR Tevfik,ŞENER Serap The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. Trakya Üniversitesi Tıp Fakültesi Dergisi, vol.25, no.2, 2008, ss.100 - 104.
AMA	ÖZKEÇECİ E,GÜLYAŞAR T,ŞENER S The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. Trakya Üniversitesi Tıp Fakültesi Dergisi. 2008; 25(2): 100 - 104.
Vancouver	ÖZKEÇECİ E,GÜLYAŞAR T,ŞENER S The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients. Trakya Üniversitesi Tıp Fakültesi Dergisi. 2008; 25(2): 100 - 104.
IEEE	ÖZKEÇECİ E,GÜLYAŞAR T,ŞENER S "The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients." Trakya Üniversitesi Tıp Fakültesi Dergisi, 25, ss.100 - 104, 2008.
ISNAD	ÖZKEÇECİ, Ercüment vd. "The association of hypertension and C825t polymorphism of the gene encoding the G-protein beta-3 subunit (GNB3) in a group of Turkish hypertensive patients". Trakya Üniversitesi Tıp Fakültesi Dergisi 25/2 (2008), 100-104.