Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome

ARMAĞAN, Onur; SIRMAGÜL, Esra; EKİM, Ayşin; TAŞÇIOĞLU, Funda; SIRMAGÜL, Başar; ÖNER, Cengiz

Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome

Onur ARMAĞAN, (Osmangazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Eskişehir, Türkiye)

Esra SIRMAGÜL, (Osmangazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Eskişehir, Türkiye)

Ayşin EKİM, (Osmangazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Eskişehir, Türkiye)

Başar SIRMAGÜL, (Osmangazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Eskişehir, Türkiye)

Funda TAŞÇIOĞLU, (Osmangazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Eskişehir, Türkiye)

Cengiz ÖNER (Osmangazi Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Eskişehir, Türkiye)

Romatizma Dergisi

1 1

Yıl: 2008 Cilt: 23 Sayı: 4 Sayfa Aralığı: 118 - 123 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome

Öz:

Amaç: Bu çalışmanın amacı, Fibromiyalji sendromlu (FMS) kadınlarla sağlıklı kadınların Kemik mineral yoğunluğunu (KMY) karşılaştırmak, aynı zamanda KMY ile insulin-like growth faktör-1 (IGF-1) arasındaki ilişkiyi tanımlamaktır. Yöntem ve Gereçler: Yirmi yedi premenopozal kadın ve aynı yaş grubunda 21 sağlıklı kadın çalışmaya alındı. Çalışmaya alınan tüm olguların vucüt kitle indeksleri (VKİ), IGF-1 ve osteokalsin düzeyleri değerlendirildi. Dual enerji X-Ray absorpsiyometri yöntemi ile femur boyun, trokanterik bölge ve lomber bölge (L 1-4 ön-arka) KMY ölçümleri yapıldı.Bulgular: Lomber ve femoral bölge KMY' ları kontrol grubu ile karşılaştırıldığında FMS' lu hastalarda anlamlı düzeyde azdı (p<0.001). IGF-1 serum konsantrasyonu FMS' lu kadınlarda sağlıklı kadınlardan önemli derecede daha düşük düzeyde idi (p<0.001). Fibromyalji sendromlu hasta grubunda IGF-1 ile KMY (trokanterik ve lomber bölge) arasında anlamlı pozitif bir korelasyon vardı. Gruplar arasında serum osteoklasin düzeyleri farklı bulunmadı.Sonuç: Bu çalışmanın sonuçları özellikle düşük IGF-1 düzeyine sahip premenopozal FMS' lu hastalarda rutin KMY ölçümlerinin yapılması gerektiğini gösterdi

Anahtar Kelime: Kemik yoğunluğu İnsülin-benzeri büyüme faktörü I Kadın Fibromiyalji Premenopoz Osteoporoz

Konular: Romatoloji

Fibromiyalji sendromlu premenopozal kadınlarda IGF-1 düzeyleri ve kemik mineral yoğunluğunun ilişkisi

Öz:

Objective: The present study aims to compare bone mineral density (BMD) of healthy female patients with that of females with fibromyalgia syndrome (FMS), as well as to determine the relationship between insulin-like growth factor-1 (IGF-1) and BMD.Materials and Methods: Twenty-seven premenopausal women with FMS and 21 age-matched female controls were included in the study. Body mass index (BMI), IGF-1 and osteocalcin levels were assessed for all the cases. BMD measurements of the femoral neck and lumbar spine were done by using dual-energy X-ray absorptiometry.Results: Lomber and femoral bone mineral density were significantly lower in FMS patients compared with controls (p<0.001). Serum concentrations of IGF-1 were significantly lower in FMS than those in healthy females (p<0.01). There was a significant correlation between IGF-1 and BMD (trochanteric and lumbar spine) in FMS patients. No difference was found between the groups with respect to serum osteocalcine levels. Conclusions: The results of the present study shows that routine BMD measurements should be done in premenopausal FMS patients, especially who have low levels of IGF-1.

Anahtar Kelime: Female Fibromyalgia Premenopause Osteoporosis Bone Density Insulin-Like Growth Factor I

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ARMAĞAN O, SIRMAGÜL E, EKİM A, SIRMAGÜL B, TAŞÇIOĞLU F, ÖNER C (2008). Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. , 118 - 123.
Chicago	ARMAĞAN Onur,SIRMAGÜL Esra,EKİM Ayşin,SIRMAGÜL Başar,TAŞÇIOĞLU Funda,ÖNER Cengiz Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. (2008): 118 - 123.
MLA	ARMAĞAN Onur,SIRMAGÜL Esra,EKİM Ayşin,SIRMAGÜL Başar,TAŞÇIOĞLU Funda,ÖNER Cengiz Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. , 2008, ss.118 - 123.
AMA	ARMAĞAN O,SIRMAGÜL E,EKİM A,SIRMAGÜL B,TAŞÇIOĞLU F,ÖNER C Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. . 2008; 118 - 123.
Vancouver	ARMAĞAN O,SIRMAGÜL E,EKİM A,SIRMAGÜL B,TAŞÇIOĞLU F,ÖNER C Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. . 2008; 118 - 123.
IEEE	ARMAĞAN O,SIRMAGÜL E,EKİM A,SIRMAGÜL B,TAŞÇIOĞLU F,ÖNER C "Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome." , ss.118 - 123, 2008.
ISNAD	ARMAĞAN, Onur vd. "Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome". (2008), 118-123.

APA	ARMAĞAN O, SIRMAGÜL E, EKİM A, SIRMAGÜL B, TAŞÇIOĞLU F, ÖNER C (2008). Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. Romatizma Dergisi , 23(4), 118 - 123.
Chicago	ARMAĞAN Onur,SIRMAGÜL Esra,EKİM Ayşin,SIRMAGÜL Başar,TAŞÇIOĞLU Funda,ÖNER Cengiz Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. Romatizma Dergisi 23, no.4 (2008): 118 - 123.
MLA	ARMAĞAN Onur,SIRMAGÜL Esra,EKİM Ayşin,SIRMAGÜL Başar,TAŞÇIOĞLU Funda,ÖNER Cengiz Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. Romatizma Dergisi , vol.23, no.4, 2008, ss.118 - 123.
AMA	ARMAĞAN O,SIRMAGÜL E,EKİM A,SIRMAGÜL B,TAŞÇIOĞLU F,ÖNER C Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. Romatizma Dergisi . 2008; 23(4): 118 - 123.
Vancouver	ARMAĞAN O,SIRMAGÜL E,EKİM A,SIRMAGÜL B,TAŞÇIOĞLU F,ÖNER C Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome. Romatizma Dergisi . 2008; 23(4): 118 - 123.
IEEE	ARMAĞAN O,SIRMAGÜL E,EKİM A,SIRMAGÜL B,TAŞÇIOĞLU F,ÖNER C "Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome." Romatizma Dergisi , 23, ss.118 - 123, 2008.
ISNAD	ARMAĞAN, Onur vd. "Levels of IGF-1 and their relationship with bone mineral density in the premenopausal women with fibromyalgia syndrome". Romatizma Dergisi 23/4 (2008), 118-123.