Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children

BALCI, Demet Benek; ÖNER, Naci; KÜÇÜKUĞURLIOĞLU, Yasemin; DURAN, Rıdvan; ÇELTİK, COŞKUN; KARASALİHOĞLU, Serap

Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children

Coşkun ÇELTİK, (Trakya Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Edirne, Türkiye)

Yasemin KÜÇÜKUĞURLIOĞLU, (Trakya Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Edirne, Türkiye)

Demet Benek BALCI, (Trakya Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Edirne, Türkiye)

Naci ÖNER, (Trakya Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Edirne, Türkiye)

Rıdvan DURAN, (Trakya Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Edirne, Türkiye)

Serap KARASALİHOĞLU (Trakya Üniversitesi, Tıp Fakültesi, Pediatri Anabilim Dalı, Edirne, Türkiye)

Trakya Üniversitesi Tıp Fakültesi Dergisi

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Yıl: 2008 Cilt: 25 Sayı: 3 Sayfa Aralığı: 221 - 227 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children

Öz:

Amaç: Epstein-Barr virüsünden kaynaklanan enfeksiyöz mononukleozun değişik semptomları, ayırıcı tanıda hekimlerin aklını karıştırabilir. Bu çalışmanın amacı semptomatik çocuklarda bu hastalışın klinik ve laboratuvar bulgularının değerlendirilmesidir. Hastalar ve Yöntemler: Bu çalışma akut Epstein- Barr virüs eneksiyonu olan 52 olgu (31 erkek, 21 kız; ort. yaş 5.4±3.4; dağılım 1-13) üzerinde retrospektif olarak yürütüldü. Klinik ve laboratuvar bulgular, şikayetler başladıktan sonraki başvuru zamanı (≤5/>5 gün) ve yaş gruplarına (≤2/>2 yıl) göre değerlendirildi.Bulgular: Major semptomlar klasik triadda yer alan ateş, lenfadenopati, tonsillofarenjit idi. Ayrıca asit, artrit ve şiddetli abdominal ağrıyla başvuran atipik olgular da tanımlandı. Hiçbir olguda kötü bir prognoz gözlenmedi. En sık rastlanan laboratuvar bulgu lenfositozdu. Major semptomlar başvuru zamanı ≤5 gün olan grupta daha sık iken, atipik lenfositler başvuru zamanı >5 gün olan grupta daha yüksek bulundu. Bu tür farklılıklar yaş grupları arasında saptanmadı.Sonuç: Epstein-Barr virüsüne bağlı enfeksiyöz mononükleoz, çocuklarda iyi prognozlu bir hastalıktır. Hastalık özellikleri başvuru gününe göre değişkenlik gösterebilir, tanıda bu durum göz önüne alınmalıdır.

Anahtar Kelime: Enfeksiyöz mononükleoz Seyir Herpesvirüs 4, insan Çocuk Geriyedönük çalışma Epstein-barr virüs enfeksiyonları

Konular: Genel ve Dahili Tıp

Çocuklarda Epstein-Barr virüsüyle ilişkili akut enfeksiyöz mononükleozun klinik ve laboratuvar özelliklerinin değerlendirilmesi

Öz:

Objectives: The various symptoms of infectious mononucleosis associated with Epstein-Barr virus may confuse physicians in differential diagnosis. The aim of this study is to evaluate the clinical and laboratory findings of this disease in symptomatic children. Patients and Methods: This study was retrospectively performed on 52 cases (31 boys, 21 girls; mean age 5.4±3.4 years; range 1 to 13 years) with acute Epstein-Barr virus infection. The clinical and laboratory findings were evaluated according to admission time after initial complaints (≤5/>5 days) and the age groups of the cases (≤2/>2 years).Results: The major symptoms were fever, lymphadenopathy and tonsillopharyngitis in the classical triad. Moreover, atypical cases who had ascites, arthritis and severe abdominal pain were defined. No case had a poor prognosis. The most frequent laboratory finding was lymphocytosis. While the major symptoms were more frequent in the group “admission time ≤ 5 days”, the count of atypical lymphocyte were higher in the group “admission time > 5 days”. However, these differences could not be defined between age groups.Conclusion: Infectious mononucleosis due to< Epstein-Barr virus is a disease with good prognosis in children. The features of the disease may vary according to admission time, and this fact should be taken into consideration in the diagnosis.

Anahtar Kelime: Herpesvirus 4, Human Child Retrospective Studies Epstein-Barr Virus Infections Infectious Mononucleosis Prognosis

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÇELTİK C, KÜÇÜKUĞURLIOĞLU Y, BALCI D, ÖNER N, DURAN R, KARASALİHOĞLU S (2008). Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. , 221 - 227.
Chicago	ÇELTİK COŞKUN,KÜÇÜKUĞURLIOĞLU Yasemin,BALCI Demet Benek,ÖNER Naci,DURAN Rıdvan,KARASALİHOĞLU Serap Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. (2008): 221 - 227.
MLA	ÇELTİK COŞKUN,KÜÇÜKUĞURLIOĞLU Yasemin,BALCI Demet Benek,ÖNER Naci,DURAN Rıdvan,KARASALİHOĞLU Serap Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. , 2008, ss.221 - 227.
AMA	ÇELTİK C,KÜÇÜKUĞURLIOĞLU Y,BALCI D,ÖNER N,DURAN R,KARASALİHOĞLU S Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. . 2008; 221 - 227.
Vancouver	ÇELTİK C,KÜÇÜKUĞURLIOĞLU Y,BALCI D,ÖNER N,DURAN R,KARASALİHOĞLU S Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. . 2008; 221 - 227.
IEEE	ÇELTİK C,KÜÇÜKUĞURLIOĞLU Y,BALCI D,ÖNER N,DURAN R,KARASALİHOĞLU S "Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children." , ss.221 - 227, 2008.
ISNAD	ÇELTİK, COŞKUN vd. "Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children". (2008), 221-227.

APA	ÇELTİK C, KÜÇÜKUĞURLIOĞLU Y, BALCI D, ÖNER N, DURAN R, KARASALİHOĞLU S (2008). Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. Trakya Üniversitesi Tıp Fakültesi Dergisi, 25(3), 221 - 227.
Chicago	ÇELTİK COŞKUN,KÜÇÜKUĞURLIOĞLU Yasemin,BALCI Demet Benek,ÖNER Naci,DURAN Rıdvan,KARASALİHOĞLU Serap Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. Trakya Üniversitesi Tıp Fakültesi Dergisi 25, no.3 (2008): 221 - 227.
MLA	ÇELTİK COŞKUN,KÜÇÜKUĞURLIOĞLU Yasemin,BALCI Demet Benek,ÖNER Naci,DURAN Rıdvan,KARASALİHOĞLU Serap Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. Trakya Üniversitesi Tıp Fakültesi Dergisi, vol.25, no.3, 2008, ss.221 - 227.
AMA	ÇELTİK C,KÜÇÜKUĞURLIOĞLU Y,BALCI D,ÖNER N,DURAN R,KARASALİHOĞLU S Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. Trakya Üniversitesi Tıp Fakültesi Dergisi. 2008; 25(3): 221 - 227.
Vancouver	ÇELTİK C,KÜÇÜKUĞURLIOĞLU Y,BALCI D,ÖNER N,DURAN R,KARASALİHOĞLU S Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children. Trakya Üniversitesi Tıp Fakültesi Dergisi. 2008; 25(3): 221 - 227.
IEEE	ÇELTİK C,KÜÇÜKUĞURLIOĞLU Y,BALCI D,ÖNER N,DURAN R,KARASALİHOĞLU S "Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children." Trakya Üniversitesi Tıp Fakültesi Dergisi, 25, ss.221 - 227, 2008.
ISNAD	ÇELTİK, COŞKUN vd. "Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children". Trakya Üniversitesi Tıp Fakültesi Dergisi 25/3 (2008), 221-227.