Yıl: 2008 Cilt: 61 Sayı: 2 Sayfa Aralığı: 77 - 81 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls

Öz:
Amaç: Kronik Ürtiker dermatolojide etyolojisi tam aydınlatılamamış konulardan biridir. Son yıllarda yapılan yayınlarda olguların %30 ile 50 sinde otoimmun mekanizmaların sorumlu olabileceği bildirilmiş olup kontakt sensitizasyonun etyolojideki rolü hala iyi anlaşılamamıştır. Kronik ürtiker etyolojik araştırmalarında prik testleri önerilmektedir. Bu çalışmada kronik ürtikerli hastaların deri yama ve prik test sonuçlarının değerlendirilmesi ve yama testi sonuçlarının sağlıklı kontrollerle karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Bu amaçla tüm laboratuar bulguları normal, otolog serum testi negatif, başka herhangi bir allerjik reaksiyon öyküsü olmayan 27 hasta ve 20 sağlıklı kontrol çalışmaya alınmıştır. Hasta grubunun lezyonları tamamen gerileyip tedavileri kesildikten 4-6 hafta sonra deri prik ve yama testleri uygulanmış, öte yandan sağlıklı kontrollere yalnızca deri yama testi yapılmıştır. Bulgular: Yirmiyedi hastanın 14 ünde deri yama testi en az bir allerjene karşı pozitif iken, prik testi pozitifliği de 14 hastada bulunmuştur. Prik testi negatif olup yama testi pozitif 7 hasta saptanmış olup, prik testi pozitif iken yama testi negatif gene 7 hasta tesbit edilmiştir. Toplam 6 hastada her iki test de negatif olarak değerlendirilmiştir. Kontrol grubunda ise yama testi pozitifliği 20 kişinin 4ünde saptanmıştır. Sonuç: Kronik ürtiker etyolojisi araştırılmasında önerilen deri prik test pozitifliği deri yama test pozitifliğinden daha sık bulunmamıştır. Sağlıklı kontrollerle karşılaştırıldığında kronik ürtikerlilerde deri yama testi pozitifliği daha sık bulunmuştur. Bu durumun ürtikerin etyolojisi mi yoksa bir sonucu mu olduğu sorusu ise ileri çalışmalarla sorgulanabilir.
Anahtar Kelime:

Konular: Cerrahi

Kronik ürtikerli olgularda patch test pozitifliğinin değerlendirilmesi ve sağlıklı kontrollerle karşılaştırılması

Öz:
Background: Chronic urticaria is one of the enigmas of dermatology. Although studies have shown that %30 - 50 of cases are autoimmune in origin exact role of contact sensitization is still unclear. Objectives: Prick tests are recommended for etiologic work up of chronic urticaria. We aimed to evaluate patch and prick test reactivities in patients with chronic urticaria and compare patch test reactivities with healthy controls. Material and Methods: We enrolled 27 patients and 20 healthy controls to the study. Patients are selected so that they didn`t have a history of allergic rhinitis,conjunctivitis, eczema or contact urticaria and had negative intradermal autologous tests. All laboratory examinations were normal. Both patch and prick tests are performed after the acute flare is over and their madicationa have been stopped for at least 4-6 weeks while only patch test is performed to the controls. Results: Fourteen of 27 patients had at least one positive patch test result. Prick test positivity was present in 14 patients as well. Seven of patch positive patients were prick negative and vice versa. Six patients didn`t have either patch or prick test positivities. Out of 20 control subjects 4 had positive patch test results. Conclusion: Patch test positivity was as frequent as prick test positivity. Comparing with healthy controls contact sensitization may be more prevalent in patients with chronic urticaria however whether this is the reason or the result of urticaria is to be further evaluated.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Kaplan AP. Chronic Urticaria and angioedema. N Engl J Med 2002; 346: 175-179.
  • 2. Clive EH, Grattan MA. Autoimmune urticaria. Immunol Allergy Clin N Am 2004; 24:163-181.
  • 3. Fusari A, Colangelo C, Bonifazi F, et al.The autologous serum skin test in the folowup of patients with chronic urticaria. Allergy 2005; 60: 256-258.
  • 4. Sabroe RA, Grattan CEH, Francis DM, et al. The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria. Br J Dermatol 1999; 140: 446-452.
  • 5. Dreskin SC, Andrews KY. The thyroid and urticaria. Curr Opin Allergy Clin Immunol 2005; 5: 408-412.
  • 6. Tong LJ, Balakrishnan G, Kochan JP,et al. Assessment of autoimmunity in patients with chronic urticaria. J Allergy Clin Immunol 1997; 99: 461-465.
  • 7. Bindslev-Jensen C, Finzi A, Greaves M, et al. Chronic urticaria: diagnostic recommendations. Eur Acad Dermatol Venereol 2000; 14: 175-180.
  • 8. Staumont-Salle D, Dombrowicz D, Capron M, et al.Eosinophils and urticaria. Clin Rev Allergy Immunol 2006; 30: 13-18.
  • 9. Tong LJ, Balakrishnan G, Kochan JP, et al. Assessment of autoimmunity in patients with chronic urticaria. J Allergy Clin Immunol 1997; 99: 461-465.
  • 10. Jacob SE, Steele T.Allergic Contact Dermatitis: Early recognition and diagnosis of important allergens. Dermatol Nurs 2006; 18: 439-443.
  • 11. Abeck D, Traencker I, Steinkraus V, et al. Chronic Urticaria due to nickel intake. Acta Derm Venereol 1993; 73:438-439.
  • 12. Hallab N, Merritt K, Jacobs JJ. Metal sensitivity in patients with orthopaedic implants. J Bone Joint Surg 2001; 83: 428.
  • 13. Warin RP, Smith RJ. Chronic urticaria investigations with patch and challenge tests. Contact Dermatitis 1982; 8: 117-121.
  • 14. Piskin G, Akyol A, Uzar H, etal. Comparative Evaluation of type 1 latex hypersensitivity in patients with chronic urticaria, rubber factory workers and healthy control subjects. Contact Dermatitis 2003; 48: 266-271.
  • 15. Deb Sharma A. Use of patch testing for identifying allergen causing chronic urticaria. Indian J Dermatl Venereol Leprol 2008; 74: 114-117.
  • 16. Guerra L, Rogkakou A, Massacane P, et al. Role of contact sensitization in chronic urticaria. J Am Acad Dermatol 2007; 56: 88-90.
APA ERDOĞAN F, ÇAKIR A, Gurler A (2008). Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. , 77 - 81.
Chicago ERDOĞAN FATMA GÜLRU,ÇAKIR Aslıhan Gül,Gurler Aysel Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. (2008): 77 - 81.
MLA ERDOĞAN FATMA GÜLRU,ÇAKIR Aslıhan Gül,Gurler Aysel Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. , 2008, ss.77 - 81.
AMA ERDOĞAN F,ÇAKIR A,Gurler A Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. . 2008; 77 - 81.
Vancouver ERDOĞAN F,ÇAKIR A,Gurler A Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. . 2008; 77 - 81.
IEEE ERDOĞAN F,ÇAKIR A,Gurler A "Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls." , ss.77 - 81, 2008.
ISNAD ERDOĞAN, FATMA GÜLRU vd. "Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls". (2008), 77-81.
APA ERDOĞAN F, ÇAKIR A, Gurler A (2008). Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 61(2), 77 - 81.
Chicago ERDOĞAN FATMA GÜLRU,ÇAKIR Aslıhan Gül,Gurler Aysel Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. Ankara Üniversitesi Tıp Fakültesi Mecmuası 61, no.2 (2008): 77 - 81.
MLA ERDOĞAN FATMA GÜLRU,ÇAKIR Aslıhan Gül,Gurler Aysel Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol.61, no.2, 2008, ss.77 - 81.
AMA ERDOĞAN F,ÇAKIR A,Gurler A Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2008; 61(2): 77 - 81.
Vancouver ERDOĞAN F,ÇAKIR A,Gurler A Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2008; 61(2): 77 - 81.
IEEE ERDOĞAN F,ÇAKIR A,Gurler A "Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls." Ankara Üniversitesi Tıp Fakültesi Mecmuası, 61, ss.77 - 81, 2008.
ISNAD ERDOĞAN, FATMA GÜLRU vd. "Evaluation of patch test positivity in patients with chronic urticaria and comparison with voluntary controls". Ankara Üniversitesi Tıp Fakültesi Mecmuası 61/2 (2008), 77-81.