The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum

ÇELIK, Sait; Yılmaz, Yilmaz, Ökkeş, Okkes; Özkaya, Ahmet; Şahin, Zafer; YÜCE, Abdurrauf

The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum

Ahmet ÖZKAYA, (Adıyaman Üniversitesi, Adıyaman, Türkiye)

Sait ÇELIK, (Bingöl Üniversitesi, Ziraat Fakültesi, Zootekni Bölümü, Bingöl, Türkiye)

Abdurrauf YÜCE, (Fırat Üniversitesi, Elazığ, Türkiye)

Zafer ŞAHİN, (Bitlis Eren Üniversitesi, Hizan Meslek Yüksek Okulu, Bitlis, Türkiye)

Ökkeş YILMAZ (Fırat Üniversitesi, Elazığ, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

13 4

Yıl: 2010 Cilt: 16 Sayı: 2 Sayfa Aralığı: 263 - 268 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum

Öz:

Antioksidan, anti-kanserojen ve antiinflamatuar etkilere sahip olan Ellagik asit (2,3,7,8-tetrahidroksil [1] benzapiranol[5,4,3cde][ 1] benzopiran-5, 10-dione) nar, ahududu, çilek, üzüm gibi pek çok taneli meyvelerde ve cevizde bulunan bitkisel polifenol türevi bir maddedir. Alüminyumun, çeşitli doku ve organlar üzerine toksik etkilere sebep olduğu bilinmektedir. Bu çalışmada, alüminyum klorür (AlCl3) ile oksidatif strese maruz kalan sıçanlarda karaciğer üzerine ellagik asit’in koruyucu etkisi araştırıldı. Bu amaçla, erişkin Spraque-dawley ırkı 24 adet erkek sıçan, rastgele dört gruba ayrıldı (n=6). Birinci grup kontrol, ikinci grup Ellagik asit grubu, üçüncü grup AlCl3 grubu, dördüncü grup ise AlCl3 + Ellagik asit grubu olarak kullanıldı. Ellagik asit 12 mg/kg dozda orogastrik sonda ile AlCl3 ise 8.3 mg/kg intraperitoneal olarak 55 gün süresince günaşırı uygulandı. Karaciğerde gulutatyon (GSH), malondialdehit (MDA), Vitamin E düzeyleri ve glutatyon peroksidaz (GSH-Px) ve katalaz (CAT) aktiviteleri belirlendi. AlCl3 kontrol grubuna göre MDA düzeyini ve CAT aktivitesini artırırken, GSH-Px aktivitesini azalttığı belirlendi. AlCl3’ün bu etkilerine karşın, ellagik asidin MDA düzeylerini azalttığı, GSH, GSH-Px ve CAT aktivitelerini artırdığı tespit edildi. Sonuçlarımıza göre, AlCl3 uygulaması neticesinde karaciğerde oluşan oksidatif hasara karşı ellagik asidin koruyucu etki potansiyeline sahip olduğu söylenebilir.

Anahtar Kelime: ahududu malondialdehit karaciğer nar antioksidan özellikleri meyve suları üzüm ellagik asit alüminyum hayvan modelleri zehirlenme oksidatif stres antienflamatuar ajanlar E vitamini glutatyon çilek sıçan oksitlenme toksisite ceviz polifenoller glutatyon peroksidaz antioksidanlar katalaz

Konular: Veterinerlik

Alüminyum ile oksidatif strese maruz kalan sıçanların karaciğerindeki bazı biyokimyasal parametreler üzerine ellagik asidin etkisi

Öz:

Antioxidant, anti-inflammatory and anti-carcinogenic effects having Ellagic acid (2,3,7,8-tetrahidroksil [1] benzapiranol [5,4,3-CDE] [1] benzopiran-5, 10-dione) pomegranate, raspberry, strawberry, many fruits such as grapes and walnuts grained derivative is a substance found in vegetable polyphenols. Aluminum is known to cause toxic effects on variety organ systems. In this study, the effect of ellagic acid on the liver of rats against oxidative stress induced by aluminum chloride (AlCl3) was investigated. Adult male Sprague-dawley rats were randomly divided in four groups. Control the first group, the second group Ellagic acid group, the third group AlCl3 group, the fourth group was used as AlCl3 + Ellagic acid. Ellagic acid 12 mg/kg dose with the orogastric probe and AlCl3 8.3 mg/kg intraperitoneal was administered as a 55 days every other day. Glutathione (GSH) in the liver, malondialdehyde (MDA), vitamin E levels and glutathione peroxidase (GSH-Px) and catalase (CAT) activities were determined. While administration of AlCl3 increased the MDA level and CAT activity, it decreased the GSH-Px activity in liver compared those of the control group. The effect of ellagic acid to AlCl3-treated rats decreased the MDA levels and increased GSH, GSH-Px and CAT activities in these samples. According to the data we obtained, a result AlCl3 application against oxidative damage in the liver, which has the potential protective effect of ellagic acid, can be said.

Anahtar Kelime: rats oxidation toxicity walnuts polyphenols glutathione peroxidase antioxidants catalase raspberries malondialdehyde liver pomegranates antioxidant properties fruit juices grapes ellagic acid aluminium animal models poisoning oxidative stress antiinflammatory agents vitamin E glutathione strawberries

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Özkaya A, ÇELIK S, YÜCE A, Şahin Z, Yılmaz, Yilmaz Ö (2010). The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. , 263 - 268.
Chicago	Özkaya Ahmet,ÇELIK Sait,YÜCE Abdurrauf,Şahin Zafer,Yılmaz, Yilmaz Ökkeş, Okkes The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. (2010): 263 - 268.
MLA	Özkaya Ahmet,ÇELIK Sait,YÜCE Abdurrauf,Şahin Zafer,Yılmaz, Yilmaz Ökkeş, Okkes The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. , 2010, ss.263 - 268.
AMA	Özkaya A,ÇELIK S,YÜCE A,Şahin Z,Yılmaz, Yilmaz Ö The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. . 2010; 263 - 268.
Vancouver	Özkaya A,ÇELIK S,YÜCE A,Şahin Z,Yılmaz, Yilmaz Ö The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. . 2010; 263 - 268.
IEEE	Özkaya A,ÇELIK S,YÜCE A,Şahin Z,Yılmaz, Yilmaz Ö "The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum." , ss.263 - 268, 2010.
ISNAD	Özkaya, Ahmet vd. "The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum". (2010), 263-268.

APA	Özkaya A, ÇELIK S, YÜCE A, Şahin Z, Yılmaz, Yilmaz Ö (2010). The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16(2), 263 - 268.
Chicago	Özkaya Ahmet,ÇELIK Sait,YÜCE Abdurrauf,Şahin Zafer,Yılmaz, Yilmaz Ökkeş, Okkes The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 16, no.2 (2010): 263 - 268.
MLA	Özkaya Ahmet,ÇELIK Sait,YÜCE Abdurrauf,Şahin Zafer,Yılmaz, Yilmaz Ökkeş, Okkes The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.16, no.2, 2010, ss.263 - 268.
AMA	Özkaya A,ÇELIK S,YÜCE A,Şahin Z,Yılmaz, Yilmaz Ö The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2010; 16(2): 263 - 268.
Vancouver	Özkaya A,ÇELIK S,YÜCE A,Şahin Z,Yılmaz, Yilmaz Ö The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2010; 16(2): 263 - 268.
IEEE	Özkaya A,ÇELIK S,YÜCE A,Şahin Z,Yılmaz, Yilmaz Ö "The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 16, ss.263 - 268, 2010.
ISNAD	Özkaya, Ahmet vd. "The effects of Ellagic acid on some biochemical parameters in the liver of rats against oxidative stress induced by Aluminum". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 16/2 (2010), 263-268.