The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients

BODUR, Said; TOL, Hüseyin; TÜRK, Süleyman; ATALAY, Hüseyin; SELÇUK, Nedim Yılmaz; BÜYÜKBAŞ, Sadık; GÜNEY, IBRAHIM; ALTINTEPE, Lütfullah; GÖKBEL, Hakkı; Tonbul, Halil Zeki; YEKSAN, Mehdi

The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients

Hüseyin TOL, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Dermatoloji Anabilim Dalı, Konya, Türkiye)

Hüseyin ATALAY, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Nefroloji Anabilim Dalı, Konya, Türkiye)

İbrahim GÜNEY, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Nefroloji Anabilim Dalı, Konya, Türkiye)

Hakkı GÖKBEL, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Fizyoloji Anabilim Dalı, Konya, Türkiye)

Lütfullah ALTINTEPE, (Meram Eğitim ve Araştırma Hastanesi, Konya, Türkiye)

Sadık BÜYÜKBAŞ, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Biyokimya Anabilim Dalı, Konya, Türkiye)

Said BODUR, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Konya, Türkiye)

Nedim Yılmaz SELÇUK, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Nefroloji Anabilim Dalı, Konya, Türkiye)

Halil Zeki TONBUL, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Nefroloji Anabilim Dalı, Konya, Türkiye)

Mehdi YEKSAN, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Nefroloji Anabilim Dalı, Konya, Türkiye)

Süleyman TÜRK, (Selçuk Üniversitesi, Meram Tıp Fakültesi, Nefroloji Anabilim Dalı, Konya, Türkiye)

Diğer Yazarlar

Trakya Üniversitesi Tıp Fakültesi Dergisi

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Yıl: 2010 Cilt: 27 Sayı: 1 Sayfa Aralığı: 1 - 5 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients

Öz:

Amaç: Gabapentin tedavisi ile kaşıntı şikayeti olan hemodiyaliz (HD) hastalarında kaşıntı, yaşam kalitesi, depresyon ve uyku kalitesindeki olası değişiklikleri tespit etmeyi amaçladık.Hastalar ve Yöntemler: Sekiz haftadan daha uzun süreli kaşıntı öyküsü olan 14 HD hastasına (7 erkek, 7 kadın; ort. yaş 59.7±17.2; dağılım 41-88) günde 300 mg gabapentin 8 hafta süre ile verildi. Çalışma öncesi 1 hafta, aktif tedavi fazı, plasebo fazı ve araya giren 1 haftalık temizlenme fazı esnasında görsel analog ölçeği kullanılarak günlük kaşıntı skorları kaydedildi. Uyku kalitesi modifiye uyku-sonrası kaydı ile, yaşam kalitesi Tıbbi Sonuç Çalışması Kısa Form-36 şekli (SF-36) ile ve depresyon da Beck Depresyon kaydı kullanılarak değerlendirildi.Bulgular: Gabapentin tedavisi ile ortalama kaşıntı skorunda ve toplam uyku-sonrası kaydı skorunda anlamlı derecede düşüş gözlendi (sırasıyla p=0.01 ve p=0.002). SF-36'nın fiziksel ve mental komponent skorları gabapentin tedavisi ile artarken, bilişsel ve somatik depresyon indeksleri gabapentin ile azaldı.Sonuç: Gabapentin tedavisi kaşıntı şikayeti olan hemodiyaliz hastalarında kaşıntı, yaşam kalitesi, depresyon ve uyku kalitesi üzerinde klinik olarak önemli yararlı etkilere sahiptir. Gabapentin tedavisi kaşıntısı olan hemodiyaliz hastalarında önemli bir tedavi seçeneği olarak göz önünde bulundurulmalıdır.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Kaşıntılı hemodiyaliz hastalarında gabapentin tedavisinin kaşıntı, yaşam kalitesi, depresyon ve uyku kalitesine etkisi

Öz:

Objectives: We aimed to determine possible changes in pruritus, quality of life, depression and sleep quality in pruritic hemodialysis (HD) patients with gabapentin therapy.Patients and Methods: Fourteen adult HD patients (7 men, 7 women; mean age 59.7±17.2 years; range 41 to 88 years) with history of pruritus of more than eight weeks were assigned to receive 8-week gabapentin (300 mg per day) therapy. The daily pruritus were recorded using visual analogue scale for each period of the study during one week preceding the trial, the active treatment phase, the placebo phase and the intervening 1-week washout period. Sleep quality was determined with a modified post-sleep inventory, quality of life with a short form of Medical Outcomes Study (SF-36), depression using the Beck Depression Inventory.Results: The mean pruritus score and total of post-sleep inventory were decreased significantly with gabapentin therapy (p=0.01 and p=0.002 respectively). Physical and mental component scales of SF-36 increased, whereas cognitive and somatic depression index decreased with gabapentin.Conclusion: We concluded that beneficial effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality are clinically important in HD patients with pruritus. Gabapentin therapy should be taken into account as an important choice of therapy in pruritic HD patients.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TOL H, ATALAY H, GÜNEY I, GÖKBEL H, ALTINTEPE L, BÜYÜKBAŞ S, BODUR S, SELÇUK N, Tonbul H, YEKSAN M, TÜRK S (2010). The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. , 1 - 5.
Chicago	TOL Hüseyin,ATALAY Hüseyin,GÜNEY IBRAHIM,GÖKBEL Hakkı,ALTINTEPE Lütfullah,BÜYÜKBAŞ Sadık,BODUR Said,SELÇUK Nedim Yılmaz,Tonbul Halil Zeki,YEKSAN Mehdi,TÜRK Süleyman The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. (2010): 1 - 5.
MLA	TOL Hüseyin,ATALAY Hüseyin,GÜNEY IBRAHIM,GÖKBEL Hakkı,ALTINTEPE Lütfullah,BÜYÜKBAŞ Sadık,BODUR Said,SELÇUK Nedim Yılmaz,Tonbul Halil Zeki,YEKSAN Mehdi,TÜRK Süleyman The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. , 2010, ss.1 - 5.
AMA	TOL H,ATALAY H,GÜNEY I,GÖKBEL H,ALTINTEPE L,BÜYÜKBAŞ S,BODUR S,SELÇUK N,Tonbul H,YEKSAN M,TÜRK S The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. . 2010; 1 - 5.
Vancouver	TOL H,ATALAY H,GÜNEY I,GÖKBEL H,ALTINTEPE L,BÜYÜKBAŞ S,BODUR S,SELÇUK N,Tonbul H,YEKSAN M,TÜRK S The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. . 2010; 1 - 5.
IEEE	TOL H,ATALAY H,GÜNEY I,GÖKBEL H,ALTINTEPE L,BÜYÜKBAŞ S,BODUR S,SELÇUK N,Tonbul H,YEKSAN M,TÜRK S "The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients." , ss.1 - 5, 2010.
ISNAD	TOL, Hüseyin vd. "The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients". (2010), 1-5.

APA	TOL H, ATALAY H, GÜNEY I, GÖKBEL H, ALTINTEPE L, BÜYÜKBAŞ S, BODUR S, SELÇUK N, Tonbul H, YEKSAN M, TÜRK S (2010). The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. Trakya Üniversitesi Tıp Fakültesi Dergisi, 27(1), 1 - 5.
Chicago	TOL Hüseyin,ATALAY Hüseyin,GÜNEY IBRAHIM,GÖKBEL Hakkı,ALTINTEPE Lütfullah,BÜYÜKBAŞ Sadık,BODUR Said,SELÇUK Nedim Yılmaz,Tonbul Halil Zeki,YEKSAN Mehdi,TÜRK Süleyman The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. Trakya Üniversitesi Tıp Fakültesi Dergisi 27, no.1 (2010): 1 - 5.
MLA	TOL Hüseyin,ATALAY Hüseyin,GÜNEY IBRAHIM,GÖKBEL Hakkı,ALTINTEPE Lütfullah,BÜYÜKBAŞ Sadık,BODUR Said,SELÇUK Nedim Yılmaz,Tonbul Halil Zeki,YEKSAN Mehdi,TÜRK Süleyman The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. Trakya Üniversitesi Tıp Fakültesi Dergisi, vol.27, no.1, 2010, ss.1 - 5.
AMA	TOL H,ATALAY H,GÜNEY I,GÖKBEL H,ALTINTEPE L,BÜYÜKBAŞ S,BODUR S,SELÇUK N,Tonbul H,YEKSAN M,TÜRK S The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. Trakya Üniversitesi Tıp Fakültesi Dergisi. 2010; 27(1): 1 - 5.
Vancouver	TOL H,ATALAY H,GÜNEY I,GÖKBEL H,ALTINTEPE L,BÜYÜKBAŞ S,BODUR S,SELÇUK N,Tonbul H,YEKSAN M,TÜRK S The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. Trakya Üniversitesi Tıp Fakültesi Dergisi. 2010; 27(1): 1 - 5.
IEEE	TOL H,ATALAY H,GÜNEY I,GÖKBEL H,ALTINTEPE L,BÜYÜKBAŞ S,BODUR S,SELÇUK N,Tonbul H,YEKSAN M,TÜRK S "The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients." Trakya Üniversitesi Tıp Fakültesi Dergisi, 27, ss.1 - 5, 2010.
ISNAD	TOL, Hüseyin vd. "The effects of gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients". Trakya Üniversitesi Tıp Fakültesi Dergisi 27/1 (2010), 1-5.