Glioblastoma with primitive neuroectodermal tumor-like features: Case report

Gul, Sanser; Bahadir, Burak; Özdamar, Şükrü Oğuz; Onak Kandemir, Nilüfer; KARADYI, Nimet

Glioblastoma with primitive neuroectodermal tumor-like features: Case report

Nilüfer Onak KANDEMİR, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Burak BAHADIR, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Şanser GÜL, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Zonguldak, Türkiye)

Nimet KARADYI, (Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, İstanbul, Türkiye)

Şükrü Oğuz ÖZDAMAR (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Turkish Neurosurgery

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Yıl: 2009 Cilt: 19 Sayı: 3 Sayfa Aralığı: 260 - 264 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Glioblastoma with primitive neuroectodermal tumor-like features: Case report

Öz:

Glioblastom (GB) erişkinde en sık rastlanan ve en agresif seyirli primer beyin tümörüdür. GB' larda küçük hücre morfolojisine sahip ve nöral immünfenotip sergileyen az diferansiye alanların varlığı oldukça nadir görülmektedir. 61 yaşında kadın hastada, fronto-temporal bölgede saptanan ve radyolojik olarak GB ile uyumlu değerlendirilen tümör dokusu total olarak eksize edildi. Histopatolojik incelemede tümor dokusunun iki farklı komponentten oluştuğu görüldü. Tümörün hakim komponenti morfolojik ve immünfenotipik olarak klasik GB özelliklerini taşımaktaydı. Diğer komponent ise küçük hücre morfolojisinde, yaygın nöronal immünfenotip sergileyen indiferansiye alanlardan oluşmaktaydı. Olgu ‘Primitif nöroektodermal tümör benzeri özellik gösteren GB' olarak tanı aldı. Operasyon sonrası radyoterapi uygulanan hastanın 9. ayda yapılan takibinde rekürrens saptanmadı. Glial tümörlerde görülen nöronal farklılaşmanın histogenezi ve prognostik önemi henüz bilinmemektedir. Patoloji raporlarında bu komponentin belirtilmesi ileri çalışmalara veri oluşturmak açısından önemlidir.

Anahtar Kelime:

Konular: Cerrahi

Pirimitif nöroektodermal tümör benzeri özellikler gösteren glioblastom: Olgu sunumu

Öz:

Glioblastoma multiforme (GB) is the most aggressive, and the most frequent primary tumor of the brain in adults. Presence of less-differentiated areas which exhibit a small cell morphology and neural immunophenotype is quite uncommon in GBs. Tumor tissue which had been determined in the frontotemporal region of a 61-year-old female patient and evaluated to be consistent with GB radiologically was subjected to total excision. Histopathological examination revealed two different components making up the tumor tissue. Using a morphological and immunophenotypic approach, the predominant component of the tumor was found to bear the properties of classic GB. The other component was composed of undifferentiated areas exhibiting small cell morphology and diffuse neuronal immunophenotype. The case was diagnosed as ‘Glioblastoma with primitive neuroectodermal tumor-like component'. The patient who had been subjected to postoperative radiotherapy, showed no sign of recurrence during the follow-up examination performed on the 9th month. The histogenesis and prognostic significance of neuronal differentiation observed in glial tumors are not known yet. Inclusion of this component in pathological reports is important regarding formation of a database for future studies.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

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APA	Onak Kandemir N, Bahadir B, Gul S, KARADYI N, Özdamar Ş (2009). Glioblastoma with primitive neuroectodermal tumor-like features: Case report. , 260 - 264.
Chicago	Onak Kandemir Nilüfer,Bahadir Burak,Gul Sanser,KARADYI Nimet,Özdamar Şükrü Oğuz Glioblastoma with primitive neuroectodermal tumor-like features: Case report. (2009): 260 - 264.
MLA	Onak Kandemir Nilüfer,Bahadir Burak,Gul Sanser,KARADYI Nimet,Özdamar Şükrü Oğuz Glioblastoma with primitive neuroectodermal tumor-like features: Case report. , 2009, ss.260 - 264.
AMA	Onak Kandemir N,Bahadir B,Gul S,KARADYI N,Özdamar Ş Glioblastoma with primitive neuroectodermal tumor-like features: Case report. . 2009; 260 - 264.
Vancouver	Onak Kandemir N,Bahadir B,Gul S,KARADYI N,Özdamar Ş Glioblastoma with primitive neuroectodermal tumor-like features: Case report. . 2009; 260 - 264.
IEEE	Onak Kandemir N,Bahadir B,Gul S,KARADYI N,Özdamar Ş "Glioblastoma with primitive neuroectodermal tumor-like features: Case report." , ss.260 - 264, 2009.
ISNAD	Onak Kandemir, Nilüfer vd. "Glioblastoma with primitive neuroectodermal tumor-like features: Case report". (2009), 260-264.

APA	Onak Kandemir N, Bahadir B, Gul S, KARADYI N, Özdamar Ş (2009). Glioblastoma with primitive neuroectodermal tumor-like features: Case report. Turkish Neurosurgery, 19(3), 260 - 264.
Chicago	Onak Kandemir Nilüfer,Bahadir Burak,Gul Sanser,KARADYI Nimet,Özdamar Şükrü Oğuz Glioblastoma with primitive neuroectodermal tumor-like features: Case report. Turkish Neurosurgery 19, no.3 (2009): 260 - 264.
MLA	Onak Kandemir Nilüfer,Bahadir Burak,Gul Sanser,KARADYI Nimet,Özdamar Şükrü Oğuz Glioblastoma with primitive neuroectodermal tumor-like features: Case report. Turkish Neurosurgery, vol.19, no.3, 2009, ss.260 - 264.
AMA	Onak Kandemir N,Bahadir B,Gul S,KARADYI N,Özdamar Ş Glioblastoma with primitive neuroectodermal tumor-like features: Case report. Turkish Neurosurgery. 2009; 19(3): 260 - 264.
Vancouver	Onak Kandemir N,Bahadir B,Gul S,KARADYI N,Özdamar Ş Glioblastoma with primitive neuroectodermal tumor-like features: Case report. Turkish Neurosurgery. 2009; 19(3): 260 - 264.
IEEE	Onak Kandemir N,Bahadir B,Gul S,KARADYI N,Özdamar Ş "Glioblastoma with primitive neuroectodermal tumor-like features: Case report." Turkish Neurosurgery, 19, ss.260 - 264, 2009.
ISNAD	Onak Kandemir, Nilüfer vd. "Glioblastoma with primitive neuroectodermal tumor-like features: Case report". Turkish Neurosurgery 19/3 (2009), 260-264.