The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

PARSAK, Cem Kaan; SAKMAN, GURHAN; KARA, BANU; GÜMÜRDÜLÜ, Yüksel; Karakoc, Emre; TAŞDOĞAN, Burçak Evren

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

Yüksel GÜMÜRDÜLÜ, (Çukurova Üniversitesi, Tıp Fakültesi, Adana, Türkiye)

Emre KARAKOÇ, (Çukurova Üniversitesi, Tıp Fakültesi, Adana, Türkiye)

Banu KARA, (Çukurova Üniversitesi, Tıp Fakültesi, Adana, Türkiye)

Burçak Evren TAŞDOĞAN, (Çukurova Üniversitesi, Tıp Fakültesi, Adana, Türkiye)

Cem Kaan PARSAK, (Çukurova Üniversitesi, Tıp Fakültesi, Adana, Türkiye)

Gürhan SAKMAN (Çukurova Üniversitesi, Tıp Fakültesi, Adana, Türkiye)

Turkish Journal of Gastroenterology

6 0

Yıl: 2010 Cilt: 21 Sayı: 1 Sayfa Aralığı: 7 - 11 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study

Öz:

Kimyasal madde içilmesi hastalarda ciddi sonuçlar oluşturabilir. Bu sonuçlardan biri olan striktür gelişimini önlemek için çeşitli tedavi prokolleri kullanılmaktadır. Biz tek başına konvansiyonel tedavi ile beraberinde oral yoğun sükralfat tedavisinin bir arada uygulanmasını karşılaştırmak amaçlı randomize prospektif bir çalışma planladık. Yöntem: 2004-2007 yılları arasında hastanemiz gastroenteroloji, genel cerrahi ve yoğun bakım ünitelerine kabul edilmiş evre 2b ve 3 koroziv özofajiti olan hastalar çalışmaya dahil edilmiştir. Hastalar iki gruba ayrılmıştır. Birinci gruptaki hastalara (n=8) konvansiyonel tedavi ile birlikte yoğun sükralfat, ikinci gruba (n=7) ise sadece konvansiyonel tedavi verilmiştir. 0, 21, 45, 90 ve 180. günlerde ortaya çıkabilecek komplikasyonları değerlendirmek için üst gastrointestinal endoskopik inceleme uygulanmıştır. Bulgular: Birinci grup hastanın sadece bir tanesinde semptom olarak disfajiye neden olmayan, 45. günde yapılan üst endoskopide saptanan ve 9,2 mm'lik endoskopun geçişine izin veren striktür oluşmuştur. Üçüncü ve altıncı ayki takiplerinde striktürde her hangi bir progresyon izlenmemiştir. İkinci grupta ise 6 hastada disfaji ve daralmaya neden olan striktür oluşumuna rastlanmıştır. Sonuç: Yoğun sükralfat tedavisi ileri evre koroziv özofajiti bulunan hastalarda striktür gelişim sıklığını azaltabilir. Daha fazla sayıda hasta içeren gruplar ile yapılacak çalışmalarla bulgularımızın destekleneceğini umuyoruz.

Anahtar Kelime: İlaç tedavisi Erişkin Özofajit Sükralfat Yanıklar, kimyasal İleriye dönük çalışma Özofagus stenozu Orta yaşlı

Konular: Cerrahi

Koroziv özofajitte sükralfatın belirgin etkinliği: Randomize ve prospektif çalışma

Öz:

Ingestion of a chemical agent is a serious problem, and several treatment protocols to prevent stricture formation have been proposed. We conducted a randomized prospective study to evaluate the effectiveness of oral intensive sucralfate plus conventional therapy compared to conventional therapy alone. Methods: Fifteen patients with stage 2b and 3 corrosive esophagitis admitted to our gastroenterology, general surgery and intensive care units between 2004 and 2007 were included. Patients were divided into two groups. The patients in the first group (n=8) received intensive sucralfate therapy plus conventional therapy, while the other group (n=7) received only conventional therapy. We performed upper endoscopic procedures on days: 0, 21, 45, 90 and 180 to identify the emergent complications. Results: In the first group, only one patient had stricture formation, allowing passage of a 9.2 mm endoscope and causing no dysphagia, on day 45. There was no progression in the stricture on follow-ups at the 3rd and 6th months. In the second group, 6 patients had stricture formation causing narrowing and dysphagia. Conclusions: Intensive sucralfate therapy may decrease the frequency of stricture formation in patients with advanced corrosive esophagitis. Further studies with large groups of patients are required to confirm our findings.

Anahtar Kelime: Middle Aged Drug Therapy Adult Esophagitis Sucralfate Burns, Chemical Prospective Studies Esophageal Stenosis

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜMÜRDÜLÜ Y, Karakoc E, KARA B, TAŞDOĞAN B, PARSAK C, SAKMAN G (2010). The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. , 7 - 11.
Chicago	GÜMÜRDÜLÜ Yüksel,Karakoc Emre,KARA BANU,TAŞDOĞAN Burçak Evren,PARSAK Cem Kaan,SAKMAN GURHAN The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. (2010): 7 - 11.
MLA	GÜMÜRDÜLÜ Yüksel,Karakoc Emre,KARA BANU,TAŞDOĞAN Burçak Evren,PARSAK Cem Kaan,SAKMAN GURHAN The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. , 2010, ss.7 - 11.
AMA	GÜMÜRDÜLÜ Y,Karakoc E,KARA B,TAŞDOĞAN B,PARSAK C,SAKMAN G The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. . 2010; 7 - 11.
Vancouver	GÜMÜRDÜLÜ Y,Karakoc E,KARA B,TAŞDOĞAN B,PARSAK C,SAKMAN G The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. . 2010; 7 - 11.
IEEE	GÜMÜRDÜLÜ Y,Karakoc E,KARA B,TAŞDOĞAN B,PARSAK C,SAKMAN G "The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study." , ss.7 - 11, 2010.
ISNAD	GÜMÜRDÜLÜ, Yüksel vd. "The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study". (2010), 7-11.

APA	GÜMÜRDÜLÜ Y, Karakoc E, KARA B, TAŞDOĞAN B, PARSAK C, SAKMAN G (2010). The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. Turkish Journal of Gastroenterology, 21(1), 7 - 11.
Chicago	GÜMÜRDÜLÜ Yüksel,Karakoc Emre,KARA BANU,TAŞDOĞAN Burçak Evren,PARSAK Cem Kaan,SAKMAN GURHAN The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. Turkish Journal of Gastroenterology 21, no.1 (2010): 7 - 11.
MLA	GÜMÜRDÜLÜ Yüksel,Karakoc Emre,KARA BANU,TAŞDOĞAN Burçak Evren,PARSAK Cem Kaan,SAKMAN GURHAN The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. Turkish Journal of Gastroenterology, vol.21, no.1, 2010, ss.7 - 11.
AMA	GÜMÜRDÜLÜ Y,Karakoc E,KARA B,TAŞDOĞAN B,PARSAK C,SAKMAN G The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. Turkish Journal of Gastroenterology. 2010; 21(1): 7 - 11.
Vancouver	GÜMÜRDÜLÜ Y,Karakoc E,KARA B,TAŞDOĞAN B,PARSAK C,SAKMAN G The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study. Turkish Journal of Gastroenterology. 2010; 21(1): 7 - 11.
IEEE	GÜMÜRDÜLÜ Y,Karakoc E,KARA B,TAŞDOĞAN B,PARSAK C,SAKMAN G "The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study." Turkish Journal of Gastroenterology, 21, ss.7 - 11, 2010.
ISNAD	GÜMÜRDÜLÜ, Yüksel vd. "The efficiency of sucralfate in corrosive esophagitis: A randomized, prospective study". Turkish Journal of Gastroenterology 21/1 (2010), 7-11.