The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation

BADAK, Özer; KIRIMLI, Önder; ASLAN, Abdurrahman; BOZDEMİR, Volkan; ŞENARSLAN, Ömer; Güneri, Sema; KALA, Veli; ÜLGENALP, Ayfer; Baris, Nezihi; AKDENİZ, Bahri; ÖZEL, Erdem

The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation

Volkan BOZDEMİR, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Önder KIRIMLI, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Bahri AKDENİZ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Ayfer ÜLGENALP, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, İzmir, Türkiye)

Abdurrahman ASLAN, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Veli KALA, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Erdem ÖZEL, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Ömer ŞENARSLAN, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Özer BADAK, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Nezihi BARIŞ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Sema GÜNERİ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Diğer Yazarlar

Anadolu Kardiyoloji Dergisi

6 4

Yıl: 2010 Cilt: 10 Sayı: 3 Sayfa Aralığı: 209 - 215 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation

Öz:

Amaç: Atriyal fibrilasyonda sol atriyal trombüs oluşması açısından koagülasyon parametrelerinin rolü yeterince araştırılmamıştır. Atriyal fibrilasyonlu hastalarda sol atriyal trombüs ile veya onun öncüsü olduğu düşünülen spontan eko-kontrast varlığı (SEK) ile beta fibrinojen gen polimorfizmi ile trombosit glikoprotein IIIa gen polimorfizmi arasındaki ilişkiyi araştırmayı amaçladık. Yöntemler: Transözofageal ekokardiyografi yapılan atriyal fibrilasyonlu 47 hasta enine kesitsel gözlemsel çalışmamıza dahil edildi. Hastalar 2 gruba ayrıldı. Sol atriyal trombüsü olanlar Grup 1’i (n=24) ve trombüsü olmayanlar grup 2’yi (n=23) oluşturdu. Beta fibrinojen gene polimorfizm veya glikoprotein IIIa gen polimorfizmlerini saptamak için genetik analizler yapıldı. İstatistiksel analizde Mann Whitney U ve Ki-kare testleri kullanıldı. Bulgular: Demografik ve klinik özellikler bakımından gruplar arasında fark saptanmadı. Beta fibrinojen 455 G/A gen polimorfizm sıklığı grup 1’de (%37.5) grup 2’ye göre (%15) istatistiksel anlamlılığa ulaşmayacak şekilde (p=0.23) daha yüksek saptandı. Çalışma grubuna ciddi SEK’i olan hastalar da eklendiğinde (trombüs ve ciddi SEK n=27) 2 grup arasındaki fark (%44.4-%10) istatistiksel anlamlılığa ulaşmaktaydı (p=0.01). Glikoprotein IIIa Pl A1/A2 polimorfizmi ise gruplar arasında (p=0.73) SEK eklense de (p=0.82) farklı bulunmadı. Grup I’de grup II’ye göre mitral yetmezliği skoru daha düşük olma eğiliminde (p=0.08), SEK skoru ise anlamı olarak daha yüksek idi (p=0.03). Sonuç: Atriyal fibrilasyonlu hastalarda beta fibrinojen 455 G/A gen polimorfizmi varlığı sol atriyal trombüs ve ciddi spontan eko-kontrast varlığı ile ilişkilidir. Glikoprotein IIIA Pl A1/A2 polimorfizminin ise sol atriyal trombüs ile ilişkisi yoktur. Atriyal fibrilasyonlu hastalarda tromboemboli riskinin belirlenmesinde beta fibrinojen gen 455 G/A polimorfizmi umut vaat eden, bir gösterge olabilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Atriyal fibrilasyonda beta-fibrinojen 455 G/A gen polimorfizmi ile sol atriyal trombüs ve ciddi spontan eko-kontrast arasındaki ilişki

Öz:

Objective: The role of coagulation parameters left atrial thrombus formation in atrial fibrillation has not been investigated before. We aimed to investigate the association between the beta-fibrinogen gene polymorphism or glycoprotein IIIa gene polymorphism and presence of left atrial (LA) thrombus or spontaneous echo contrast (SEC) in patients with atrial fibrillation (AF). Methods: Forty-seven patients with AF, in whom transesophageal echocardiography was performed, were included to this cross-sectional observational study. Patients were divided in two groups; those with LA thrombus (n=24) were assigned to group 1 and those without thrombus-in group 2 (n=23). DNA analysis was conducted to determine gene polymorphism in all patients. Mann-Whitney U test or Chi-square tests were used for statistical analysis Results: There were no significant differences between groups regarding to demographic and clinical characteristics. The frequency of beta-fibrinogen 455 G/A polymorphism was higher (37.5%) in group 1 as compared to group 2 (15.1%) but it did not reach statistical difference (p=0.23). When we added patients with severe SEC in the study group (patients with severe SEC and/or thrombus n=27) the difference (44.40%-10%) reached the statistical difference (p=0.01). Glycoprotein IIIa Pl A1/A2 polymorphism was not different between groups with (p=0.82) or without SEC (p=0.73). Conclusion: In patients with atrial fibrillation, beta-fibrinogen 455 G/A gene polymorphism is associated with the presence of left atrial thrombus and severe SEC. Beta-fibrinogen 455 G/A gene polymorphism may be a promising marker for the prediction of thromboembolism risk in patients with atrial fibrillation.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BOZDEMİR V, KIRIMLI Ö, AKDENİZ B, ÜLGENALP A, ASLAN A, KALA V, ÖZEL E, ŞENARSLAN Ö, BADAK Ö, Baris N, Güneri S (2010). The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. , 209 - 215.
Chicago	BOZDEMİR Volkan,KIRIMLI Önder,AKDENİZ Bahri,ÜLGENALP Ayfer,ASLAN Abdurrahman,KALA Veli,ÖZEL Erdem,ŞENARSLAN Ömer,BADAK Özer,Baris Nezihi,Güneri Sema The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. (2010): 209 - 215.
MLA	BOZDEMİR Volkan,KIRIMLI Önder,AKDENİZ Bahri,ÜLGENALP Ayfer,ASLAN Abdurrahman,KALA Veli,ÖZEL Erdem,ŞENARSLAN Ömer,BADAK Özer,Baris Nezihi,Güneri Sema The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. , 2010, ss.209 - 215.
AMA	BOZDEMİR V,KIRIMLI Ö,AKDENİZ B,ÜLGENALP A,ASLAN A,KALA V,ÖZEL E,ŞENARSLAN Ö,BADAK Ö,Baris N,Güneri S The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. . 2010; 209 - 215.
Vancouver	BOZDEMİR V,KIRIMLI Ö,AKDENİZ B,ÜLGENALP A,ASLAN A,KALA V,ÖZEL E,ŞENARSLAN Ö,BADAK Ö,Baris N,Güneri S The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. . 2010; 209 - 215.
IEEE	BOZDEMİR V,KIRIMLI Ö,AKDENİZ B,ÜLGENALP A,ASLAN A,KALA V,ÖZEL E,ŞENARSLAN Ö,BADAK Ö,Baris N,Güneri S "The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation." , ss.209 - 215, 2010.
ISNAD	BOZDEMİR, Volkan vd. "The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation". (2010), 209-215.

APA	BOZDEMİR V, KIRIMLI Ö, AKDENİZ B, ÜLGENALP A, ASLAN A, KALA V, ÖZEL E, ŞENARSLAN Ö, BADAK Ö, Baris N, Güneri S (2010). The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. Anadolu Kardiyoloji Dergisi, 10(3), 209 - 215.
Chicago	BOZDEMİR Volkan,KIRIMLI Önder,AKDENİZ Bahri,ÜLGENALP Ayfer,ASLAN Abdurrahman,KALA Veli,ÖZEL Erdem,ŞENARSLAN Ömer,BADAK Özer,Baris Nezihi,Güneri Sema The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. Anadolu Kardiyoloji Dergisi 10, no.3 (2010): 209 - 215.
MLA	BOZDEMİR Volkan,KIRIMLI Önder,AKDENİZ Bahri,ÜLGENALP Ayfer,ASLAN Abdurrahman,KALA Veli,ÖZEL Erdem,ŞENARSLAN Ömer,BADAK Özer,Baris Nezihi,Güneri Sema The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. Anadolu Kardiyoloji Dergisi, vol.10, no.3, 2010, ss.209 - 215.
AMA	BOZDEMİR V,KIRIMLI Ö,AKDENİZ B,ÜLGENALP A,ASLAN A,KALA V,ÖZEL E,ŞENARSLAN Ö,BADAK Ö,Baris N,Güneri S The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. Anadolu Kardiyoloji Dergisi. 2010; 10(3): 209 - 215.
Vancouver	BOZDEMİR V,KIRIMLI Ö,AKDENİZ B,ÜLGENALP A,ASLAN A,KALA V,ÖZEL E,ŞENARSLAN Ö,BADAK Ö,Baris N,Güneri S The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. Anadolu Kardiyoloji Dergisi. 2010; 10(3): 209 - 215.
IEEE	BOZDEMİR V,KIRIMLI Ö,AKDENİZ B,ÜLGENALP A,ASLAN A,KALA V,ÖZEL E,ŞENARSLAN Ö,BADAK Ö,Baris N,Güneri S "The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation." Anadolu Kardiyoloji Dergisi, 10, ss.209 - 215, 2010.
ISNAD	BOZDEMİR, Volkan vd. "The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation". Anadolu Kardiyoloji Dergisi 10/3 (2010), 209-215.