Yıl: 2010 Cilt: 47 Sayı: 3 Sayfa Aralığı: 247 - 251 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression

Öz:
Amaç: Elektrokonvülzif tedavinin (EKT) oksidatif metabolizma üzerine etkileri ile ilgili literatürün çoğu hayvan deneylerine dayanmaktadır ve oksidan/antioksidan dengenin değiştiğine dair çelişkili sonuçlar içermektedir. Bu alanda yapılan ilk insan çalışması olan bu çalışmanın amacı depresif hastalarda EKT sonrası oksidan ve antioksidanlardaki değişimleri araştırmaktır.Yöntemler: On dört unipolar ve iki bipolar depresyon hastası çalışmaya dahil edildi. Kan örnekleri ilk EKT seansından 1 saat once ve 7. EKT seansından 1 saat sonra alındı. Plazmada oksidanlardan malondialdehit (MDA), nitrik oksit (NO) ve ksantin oksidaz (XO); antioksidanlardan süperoksit dismutaz (SOD) seviyeleri ölçüldü.Bulgular: Birinci ve 7. EKT seansından sonraki Hamilton Depresyon Ölçeği (HAM-D) skorları 32.63±9.54 ve 16.50±7.22 idi (t=7.92, df=15, p<0.001). Yedinci EKT sonrası SOD değerleri EKT öncesi SOD değerlerinden anlamlı olarak düşüktü (p<0.05, Z= -3,459). EKT öncesi ve sonrası MDA, NO ve XO değerleri arasında anlamlı bir farklılık yoktu (p>0.05). Bununla birlikte, EKT öncesi SOD değerleri EKT öncesi HAM-D skorları ile anlamlı düzeyde pozitif korelasyon gösteriyordu (r=0.641, p=0.007).Sonuç: EKT sonrası antioksidan bir enzim olan SOD düzeyindeki düşüş oksidatif stresi arttırarak nöronlara zarar verebilir. Bu nedenle EKT uygulama dönemlerinde antioksidan ekleme tedavilerinin olası faydaları araştırılmalıdır. Yine EKT öncesi yüksek oksidan seviyeleri depresyon hastalarında EKT’ye kötü yanıtı yordayabilir.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Genel ve Dahili Tıp Hematoloji Biyokimya ve Moleküler Biyoloji Hücre Biyolojisi Biyofizik

Depresyonda EKT sonrası süperoksit dismutaz aktivitesi düşüyor ve EKT'ye kötü yanıtla korelasyon gösteriyor

Öz:
Objective: The literature regarding effects of electroconvulsive therapy (ECT) on oxidative metabolism (OM) reports conflicting changes in oxidant and antioxidant status in animal studies. The goal of this first human study was to investigate the changes in oxidants and antioxidants in plasma of depressed patients after ECT.Methods: Fourteen unipolar and two bipolar patients were included in the study. The blood samples were obtained within one hour before the 1st and within one hour after the 7th ECT sessions. Oxidants malondialdehyde (MDA), nitric oxide (NO), and xanthine oxidase (XO) and antioxidant superoxide dismutase (SOD) were measured in the plasma.Results: Before the 1st and after the 7th ECT sessions, the Hamilton Depression Rating Scale (HDRS) scores were 32.63±9.54 and 16.50±7.22, respectively (t=7.92, df=15, p<0.001). After the 7th ECT, SOD values were significantly lower than pre-ECT SOD values (p<0.05, Z= -3,459). There were no significant difference between pre-and post-ECT values of MDA, NO, and XO (p>0.05). However, pre-ECT SOD values were significantly and positively correlated with pre-ECT HDRS scores (r=0.641, p=0.007).Conclusion: The decrease in antioxidant enzyme SOD after ECT may damage the neurons by increasing oxidative stress. Thus, possible benefits of antioxidant supplementation during ECT should be investigated. Additionally, higher pre-ECT oxidant levels may predict a poor response to ECT in depression.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Genel ve Dahili Tıp Hematoloji Biyokimya ve Moleküler Biyoloji Hücre Biyolojisi Biyofizik
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA VIRIT O, DALKİLİÇ A, BULUT M, BÜLBÜL F, ALTINDAĞ A, ARMUTÇU F, KOÇOĞLU E, ÇITAK S, SAVAŞ H (2010). Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. , 247 - 251.
Chicago VIRIT Osman,DALKİLİÇ Alican,BULUT Mahmut,BÜLBÜL FERİDUN,ALTINDAĞ Abdurrahman,ARMUTÇU Ferrah,KOÇOĞLU Esra,ÇITAK Serhat,SAVAŞ Haluk Asuman Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. (2010): 247 - 251.
MLA VIRIT Osman,DALKİLİÇ Alican,BULUT Mahmut,BÜLBÜL FERİDUN,ALTINDAĞ Abdurrahman,ARMUTÇU Ferrah,KOÇOĞLU Esra,ÇITAK Serhat,SAVAŞ Haluk Asuman Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. , 2010, ss.247 - 251.
AMA VIRIT O,DALKİLİÇ A,BULUT M,BÜLBÜL F,ALTINDAĞ A,ARMUTÇU F,KOÇOĞLU E,ÇITAK S,SAVAŞ H Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. . 2010; 247 - 251.
Vancouver VIRIT O,DALKİLİÇ A,BULUT M,BÜLBÜL F,ALTINDAĞ A,ARMUTÇU F,KOÇOĞLU E,ÇITAK S,SAVAŞ H Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. . 2010; 247 - 251.
IEEE VIRIT O,DALKİLİÇ A,BULUT M,BÜLBÜL F,ALTINDAĞ A,ARMUTÇU F,KOÇOĞLU E,ÇITAK S,SAVAŞ H "Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression." , ss.247 - 251, 2010.
ISNAD VIRIT, Osman vd. "Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression". (2010), 247-251.
APA VIRIT O, DALKİLİÇ A, BULUT M, BÜLBÜL F, ALTINDAĞ A, ARMUTÇU F, KOÇOĞLU E, ÇITAK S, SAVAŞ H (2010). Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. Nöropsikiyatri Arşivi, 47(3), 247 - 251.
Chicago VIRIT Osman,DALKİLİÇ Alican,BULUT Mahmut,BÜLBÜL FERİDUN,ALTINDAĞ Abdurrahman,ARMUTÇU Ferrah,KOÇOĞLU Esra,ÇITAK Serhat,SAVAŞ Haluk Asuman Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. Nöropsikiyatri Arşivi 47, no.3 (2010): 247 - 251.
MLA VIRIT Osman,DALKİLİÇ Alican,BULUT Mahmut,BÜLBÜL FERİDUN,ALTINDAĞ Abdurrahman,ARMUTÇU Ferrah,KOÇOĞLU Esra,ÇITAK Serhat,SAVAŞ Haluk Asuman Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. Nöropsikiyatri Arşivi, vol.47, no.3, 2010, ss.247 - 251.
AMA VIRIT O,DALKİLİÇ A,BULUT M,BÜLBÜL F,ALTINDAĞ A,ARMUTÇU F,KOÇOĞLU E,ÇITAK S,SAVAŞ H Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. Nöropsikiyatri Arşivi. 2010; 47(3): 247 - 251.
Vancouver VIRIT O,DALKİLİÇ A,BULUT M,BÜLBÜL F,ALTINDAĞ A,ARMUTÇU F,KOÇOĞLU E,ÇITAK S,SAVAŞ H Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression. Nöropsikiyatri Arşivi. 2010; 47(3): 247 - 251.
IEEE VIRIT O,DALKİLİÇ A,BULUT M,BÜLBÜL F,ALTINDAĞ A,ARMUTÇU F,KOÇOĞLU E,ÇITAK S,SAVAŞ H "Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression." Nöropsikiyatri Arşivi, 47, ss.247 - 251, 2010.
ISNAD VIRIT, Osman vd. "Decreased superoxide dismutase activity after ECT and correlation between higher oxidant levels and poor response to ECT in depression". Nöropsikiyatri Arşivi 47/3 (2010), 247-251.