Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports

AYDEMİR, Selim; Bahadir, Burak; Özdamar, Şükrü Oğuz; Onak Kandemir, Nilüfer; YURDAKAN, Gamze; BEKTAŞ, Sibel; DOĞAN GÜN, Banu; Barut, Figen; Engin, Hüseyin

Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports

Nilüfer ONAK KANDEMİR, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Burak BAHADIR, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Sibel BEKTAŞ, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Figen BARUT, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Gamze YURDAKAN, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Banu DOĞAN GÜN, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Hüseyin ENGİN, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Anabilim Dalı, Zonguldak, Türkiye)

Selim AYDEMİR, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Zonguldak, Türkiye)

Şükrü Oğuz ÖZDAMAR (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Turkish Journal of Gastroenterology

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Yıl: 2011 Cilt: 22 Sayı: 1 Sayfa Aralığı: 77 - 82 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports

Öz:

Konjenital melanositik nevüs, odontogenez sırasında ortaya çıkan ve nöral-krest’den gelişen hamartomatöz lezyonlardır. Bu çalışmada konjenital melanositik nevüsden gelişen ve gastrointestinal sistem metastazları ile bulgu veren iki malign melanoma olgusu sunulmaktadır. İlk olgu, plevral ve peritoneal efüzyon ile başvuran 71 yaşında kadın hasta olup, endoskopik incelenmede doudenumda nodüler lezyonlar saptanmış ve biyopsi yapılmıştır. Karın ağrısı yakınması ile başvuran ikinci olgu 36 yaşında erkek hasta olup, ileumda invajinasyonlara neden olan kitlesel lezyonlar nedeniyle segmenter ileal rezeksiyon uygulanmıştır. Lezyonların histopatolojik incelemesinde tüm mukoza katlarını infiltre eden diffüz neoplastik infiltrasyon görülmüştür. Belirgin atipi ve pleomorfizm içeren neoplastik hücrelerde S-100, HMB-45 ve Melan A immünreaksiyon saptanmıştır. Her iki olguya, malign melanoma tanısı verilmiştir. İlk olguda karın derisinde, ikinci olguda ise femoral bölgede konjenital melanositik nevüs saptanmış ve histopatolojik incelemelerde bu lezyonların malign melanoma yönünde transformasyon gösterdiği belirlenmiştir. Gastrointestinal sistemde malign melanoma gelişimi primer veya metastatik kökenli olabilir. Kesin tanı daima ayrıntılı klinik, histopatolojik ve immünhistokimyasal incelemeleri gerektirir.

Anahtar Kelime:

Konular: Cerrahi

Konjenital melanositik nevüsten köken alan ve intestinal metastazları ile tanı konan malign melanoma: iki olgu sunumu

Öz:

Congenital melanocytic nevi are hamartomatous lesions that develop from the neural crest and arise during odontogenesis. In this report, we present two malignant melanoma cases developed from congenital melanocytic nevi and revealed by gastrointestinal system metastases. The first case was a 71-year-old female who presented with pleural and peritoneal effusion and underwent biopsy due to detection of nodular lesions in the duodenum by endoscopic examination. The second case was a 36-year-old male patient who presented with abdominal pain in whom segmental ileal resection was performed due to mass lesions causing invaginations in the ileum. Histopathological examination of the lesions showed a diffuse neoplastic infiltration comprising the entire mucosal layers. In neoplastic cells having a marked atypia and pleomorphism, immunoreactions with S-100, HMB-45, and Melan A were detected. Both cases were diagnosed as malignant melanoma. Abdominal skin in the first case and the femoral region in the second case exhibited congenital melanocytic nevi, and those lesions were determined to show a transformation towards malignant melanoma in the histopathological studies. Malignant melanoma development in gastrointestinal system may have a primary or metastatic character. Definitive diagnosis always requires detailed clinical, histopathological and immunohistochemical analyses.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

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APA	Onak Kandemir N, Bahadir B, BEKTAŞ S, Barut F, YURDAKAN G, DOĞAN GÜN B, Engin H, AYDEMİR S, Özdamar Ş (2011). Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. , 77 - 82.
Chicago	Onak Kandemir Nilüfer,Bahadir Burak,BEKTAŞ Sibel,Barut Figen,YURDAKAN Gamze,DOĞAN GÜN Banu,Engin Hüseyin,AYDEMİR Selim,Özdamar Şükrü Oğuz Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. (2011): 77 - 82.
MLA	Onak Kandemir Nilüfer,Bahadir Burak,BEKTAŞ Sibel,Barut Figen,YURDAKAN Gamze,DOĞAN GÜN Banu,Engin Hüseyin,AYDEMİR Selim,Özdamar Şükrü Oğuz Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. , 2011, ss.77 - 82.
AMA	Onak Kandemir N,Bahadir B,BEKTAŞ S,Barut F,YURDAKAN G,DOĞAN GÜN B,Engin H,AYDEMİR S,Özdamar Ş Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. . 2011; 77 - 82.
Vancouver	Onak Kandemir N,Bahadir B,BEKTAŞ S,Barut F,YURDAKAN G,DOĞAN GÜN B,Engin H,AYDEMİR S,Özdamar Ş Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. . 2011; 77 - 82.
IEEE	Onak Kandemir N,Bahadir B,BEKTAŞ S,Barut F,YURDAKAN G,DOĞAN GÜN B,Engin H,AYDEMİR S,Özdamar Ş "Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports." , ss.77 - 82, 2011.
ISNAD	Onak Kandemir, Nilüfer vd. "Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports". (2011), 77-82.

APA	Onak Kandemir N, Bahadir B, BEKTAŞ S, Barut F, YURDAKAN G, DOĞAN GÜN B, Engin H, AYDEMİR S, Özdamar Ş (2011). Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. Turkish Journal of Gastroenterology, 22(1), 77 - 82.
Chicago	Onak Kandemir Nilüfer,Bahadir Burak,BEKTAŞ Sibel,Barut Figen,YURDAKAN Gamze,DOĞAN GÜN Banu,Engin Hüseyin,AYDEMİR Selim,Özdamar Şükrü Oğuz Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. Turkish Journal of Gastroenterology 22, no.1 (2011): 77 - 82.
MLA	Onak Kandemir Nilüfer,Bahadir Burak,BEKTAŞ Sibel,Barut Figen,YURDAKAN Gamze,DOĞAN GÜN Banu,Engin Hüseyin,AYDEMİR Selim,Özdamar Şükrü Oğuz Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. Turkish Journal of Gastroenterology, vol.22, no.1, 2011, ss.77 - 82.
AMA	Onak Kandemir N,Bahadir B,BEKTAŞ S,Barut F,YURDAKAN G,DOĞAN GÜN B,Engin H,AYDEMİR S,Özdamar Ş Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. Turkish Journal of Gastroenterology. 2011; 22(1): 77 - 82.
Vancouver	Onak Kandemir N,Bahadir B,BEKTAŞ S,Barut F,YURDAKAN G,DOĞAN GÜN B,Engin H,AYDEMİR S,Özdamar Ş Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports. Turkish Journal of Gastroenterology. 2011; 22(1): 77 - 82.
IEEE	Onak Kandemir N,Bahadir B,BEKTAŞ S,Barut F,YURDAKAN G,DOĞAN GÜN B,Engin H,AYDEMİR S,Özdamar Ş "Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports." Turkish Journal of Gastroenterology, 22, ss.77 - 82, 2011.
ISNAD	Onak Kandemir, Nilüfer vd. "Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: two case reports". Turkish Journal of Gastroenterology 22/1 (2011), 77-82.