Fifty-six patients admitted to Inonu University Gastroenterology Department and detected duodenal or gastric ulcer in their endoscopies with Helicobacter pylori positivity in their endoscopic biopsies included in the study. The mean age of the patients was 37. Patients were divided in to two groups. Of 30 patients in the first group were given ranitidine bismuth citrate (RBC), 400 mg twice daily for one month, plus clarithromycin, 500 mg twice daily for one week, and amoxicillin, 1 gr twice daily for one week. Of 26 patients in the second group were given ranitidine, 300 mg twice daily for one month, plus clarithromycin, 500 mg twice daily for one week, and amoxicillin, 1 gr twice daily for one week. Endoscopic biopsies were repeated two weeks later at the end of the therapy and it was accepted as H. Pylori eradicated in negative biopsies. The H.pylori eradication rate was 100 % (24/24) in the first group and 69.5 % (16/23) in the second group with statistically significant difference. Ulcer healing rate was 100 % (24/24) in the first group and 86.9 % (20/23) in the second group with statistically significant difference. Both two regimens were well tolerated.