Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study

AKYÜZ, Ali Rıza; ERKUŞ, Muslihittin Emre; KIRIŞ, ABDULKADİR; KORKMAZ, Levent; AĞAÇ, Mustafa Tarık; KUL, Selim; KORKMAZ ATA, Ayça; ÇELİK, Şükrü; ACAR, Zeydin

Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study

Levent KORKMAZ, (Sağlık Bakanlığı, Ahi Evren Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Trabzon, Türkiye)

Ayça KORKMAZ ATA, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Trabzon, Türkiye)

Ali Rıza AKYÜZ, (Akçaabat Haçkalı Baba Devlet Hastanesi, Kardiyoloji Kliniği, Trabzon, Türkiye)

Mustafa Tarık AĞAÇ, (Sağlık Bakanlığı, Ahi Evren Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Trabzon, Türkiye)

Zeydin ACAR, (Sağlık Bakanlığı, Ahi Evren Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Trabzon, Türkiye)

Abdulkadir KIRIŞ, (Sağlık Bakanlığı, Ahi Evren Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Trabzon, Türkiye)

Selim KUL, (Sinop Atatürk Devlet Hastanesi, Kardiyoloji Kliniği, Sinop, Türkiye)

Muslihittin Emre ERKUŞ, (Sağlık Bakanlığı, Ahi Evren Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Trabzon, Türkiye)

Şükrü ÇELİK (Sağlık Bakanlığı, Ahi Evren Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Trabzon, Türkiye)

Anadolu Kardiyoloji Dergisi

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Yıl: 2012 Cilt: 12 Sayı: 1 Sayfa Aralığı: 35 - 39 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study

Öz:

dolaylı bir parametredir. Koroner arter kalsifikasyonunun (KAK) aterosklerotik proçesin bir parçası olduğu uzun zamandır bilinmektedir. Bu çalışmamızda aşikar kardiyovasküler hastalığı olmayan hastalarda KAK ile OTH arasındaki ilişkiyi inceledik. Yöntemler: Bu gözlemsel çalışmada, bilinen kardiyovasküler hastalığı olmayan ve en az bir kardiyovasküler riski olan 259 hasta çalışmaya alındı. KAK çok kesitli tomografi ile değerlendirildi. OTH ise etilen diamin tetra asetik asit (EDTA)’li tüplere alınan kanda ölçüldü. İstatistiksel analiz Kruskal-Wallis, Ki-kare, korelasyon testleri ve çoklu regresyon analiz ile yapıldı. Bulgular: Kalsiyum skoru 0 ile 735 arasında idi. Tek yönlü analizde KAK ile OTH (r=0.24, p=0.02), yaş (r=0.32, p<0.001), hipertansiyon (r=0.19, p=0.03), diyabet (r=0.16, p=0.005) ve sigara içimi (r=0.17, p=0.001) arasında anlamlı bir ilişki vardı. Çok yönlü analizde ise OTH (β=0.4, %95GA 19.8- 31.1, p<0.001), yaş (β=0.13, %95GA 0.23-2.4 p=0.01) ve sigara içimi (β=0.12, %95GA 3.2-15.1, p=0.02) KAK’ın bağımsız belirleyicileri idi. Ayrıca anlamlı KAK’ı olanlarda minimal ya da KAK’ı olmayan hastalara göre OTH anlamlı olarak yüksek idi (10.2±2.4 karşı 8.1±0.9 ve 7.6±1.3; R2=52.7, p<0.001). Sonuç: Çalışmamızda OTH ile KAK arasında anlamlı bir ilişki bulduk. Her ne kadar çalışmamız bir korelasyon çalışması olduğu için neden- sonuç ilişkisi açısından bir sonuç çıkarmak zor olsa da yüksek OTH’nin artmış aterosklerotik yükü ve kardiyovasküler riski gösterebileceği söylenebilir. (Anadolu Kardiyol Derg 2012; 12: 35-9)

Anahtar Kelime: Regresyon analizi Kalp damar hastalıkları Trombosit aktivasyonu Ateroskleroz

Konular: Kalp ve Kalp Damar Sistemi

Aşikar kardiyovasküler hastalığı olmayanlarda koroner arter kalsifikasyonu ile ortalama trombosit hacmi arasındaki ilişki: Gözlemsel bir çalışma

Öz:

Objective: Platelets have an important role in the pathogenesis of atherothrombosis. It has been shown that platelet size measured by mean platelet volume (MPV), correlates with their reactivity and is still regarded as an easy, useful tool for indirect monitoring of platelet activity in different situations. Coronary artery calcification (CAC) has long been known to occur as a part of the atherosclerotic process. The aim of this study was to determine whether an association exists between MPV and CAC. Methods: In this observational study, we enrolled 259 participants with at least one cardiac risk factor but with unknown cardiovascular disease. Coronary calcification was assessed by multislice computerized tomography and MPV was measured in a blood sample collected in EDTA tubes. Statistical analysis was performed using Kruskal-Wallis, Chi-square, correlation tests and multiple regression analysis. Results: Calcium scores ranged from 0 to 735. There was a significant relation between CAC and MPV (r=0.24, p=0.02), age (r=0.32, p<0.001), hypertension (r=0.19, p=0.03), diabetes (r=0.16, p=0.005), smoking (r=0.17, p=0.001). In linear regression analysis, MPV (β=0.4, 95%CI 19.8- 31.1, p<0.001), age (β=0.13, 95%CI 0.23-2.4, p=0.01) and smoking (β=0.12, 95%CI 3.2-15.1, p=0.02) independently associated with CAC. In addition, there were significant differences in MPV between significant CAC group compared to the minimal and none (10.2±2.4 versus 8.1±0.9 and 7.6±1.3; p<0.001). Conclusion: We have found significant association between MPV and CAC. Although this study is purely correlative and no causative conclusions can be drawn, it may suggest that higher MPV may reflect increased atherosclerotic burden and cardiovascular risk. (Anadolu Kardiyol Derg 2012; 12: 35-9)

Anahtar Kelime: Platelet Activation Atherosclerosis Regression Analysis Cardiovascular Diseases

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KORKMAZ L, KORKMAZ ATA A, AKYÜZ A, AĞAÇ M, ACAR Z, KIRIŞ A, KUL S, ERKUŞ M, ÇELİK Ş (2012). Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. , 35 - 39.
Chicago	KORKMAZ Levent,KORKMAZ ATA Ayça,AKYÜZ Ali Rıza,AĞAÇ Mustafa Tarık,ACAR Zeydin,KIRIŞ ABDULKADİR,KUL Selim,ERKUŞ Muslihittin Emre,ÇELİK Şükrü Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. (2012): 35 - 39.
MLA	KORKMAZ Levent,KORKMAZ ATA Ayça,AKYÜZ Ali Rıza,AĞAÇ Mustafa Tarık,ACAR Zeydin,KIRIŞ ABDULKADİR,KUL Selim,ERKUŞ Muslihittin Emre,ÇELİK Şükrü Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. , 2012, ss.35 - 39.
AMA	KORKMAZ L,KORKMAZ ATA A,AKYÜZ A,AĞAÇ M,ACAR Z,KIRIŞ A,KUL S,ERKUŞ M,ÇELİK Ş Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. . 2012; 35 - 39.
Vancouver	KORKMAZ L,KORKMAZ ATA A,AKYÜZ A,AĞAÇ M,ACAR Z,KIRIŞ A,KUL S,ERKUŞ M,ÇELİK Ş Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. . 2012; 35 - 39.
IEEE	KORKMAZ L,KORKMAZ ATA A,AKYÜZ A,AĞAÇ M,ACAR Z,KIRIŞ A,KUL S,ERKUŞ M,ÇELİK Ş "Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study." , ss.35 - 39, 2012.
ISNAD	KORKMAZ, Levent vd. "Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study". (2012), 35-39.

APA	KORKMAZ L, KORKMAZ ATA A, AKYÜZ A, AĞAÇ M, ACAR Z, KIRIŞ A, KUL S, ERKUŞ M, ÇELİK Ş (2012). Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. Anadolu Kardiyoloji Dergisi, 12(1), 35 - 39.
Chicago	KORKMAZ Levent,KORKMAZ ATA Ayça,AKYÜZ Ali Rıza,AĞAÇ Mustafa Tarık,ACAR Zeydin,KIRIŞ ABDULKADİR,KUL Selim,ERKUŞ Muslihittin Emre,ÇELİK Şükrü Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. Anadolu Kardiyoloji Dergisi 12, no.1 (2012): 35 - 39.
MLA	KORKMAZ Levent,KORKMAZ ATA Ayça,AKYÜZ Ali Rıza,AĞAÇ Mustafa Tarık,ACAR Zeydin,KIRIŞ ABDULKADİR,KUL Selim,ERKUŞ Muslihittin Emre,ÇELİK Şükrü Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. Anadolu Kardiyoloji Dergisi, vol.12, no.1, 2012, ss.35 - 39.
AMA	KORKMAZ L,KORKMAZ ATA A,AKYÜZ A,AĞAÇ M,ACAR Z,KIRIŞ A,KUL S,ERKUŞ M,ÇELİK Ş Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. Anadolu Kardiyoloji Dergisi. 2012; 12(1): 35 - 39.
Vancouver	KORKMAZ L,KORKMAZ ATA A,AKYÜZ A,AĞAÇ M,ACAR Z,KIRIŞ A,KUL S,ERKUŞ M,ÇELİK Ş Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study. Anadolu Kardiyoloji Dergisi. 2012; 12(1): 35 - 39.
IEEE	KORKMAZ L,KORKMAZ ATA A,AKYÜZ A,AĞAÇ M,ACAR Z,KIRIŞ A,KUL S,ERKUŞ M,ÇELİK Ş "Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study." Anadolu Kardiyoloji Dergisi, 12, ss.35 - 39, 2012.
ISNAD	KORKMAZ, Levent vd. "Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: An observational study". Anadolu Kardiyoloji Dergisi 12/1 (2012), 35-39.