There are two extensive, systematic and fundamental cultural transmutations held in the Islamic world during its history one of which initiates by the invasion of Islam over the Sasanian and Byzantian territories, and of another in the 18th-century by the Ottoman Empire. Both can be qualified as cultural transmutations towards Western destination, and both are organically interconnected events. The first fact has been shadowed in the literature by the concept of translation movement in Islam. The very fact, however, can be observed through integrating the disconnected determinations already made in the present literature such as Hellenization of Arabic grammar, Romanization of Islamic empires, etc. The second fact is also underrated due to the political conflictions between the Ottoman Empire and the Western world. Interconnecting these two historical facts, we obtain one single way in understanding Islamic politics. Focusing on the relationship between the first six Qur'ânic verses of Sürat al-Rûm (Sürat of Rome), the ancient confiiction between tlfe Sasanite and Hellenic worlds which was absorbed by Islam, and the mawali community that was massively originated by the Sasanite and the Hellenic peoples, I will undertake the constitutional and social dynamics of the political attitude of Islam towards the Western world, including the classical criticisms of various Muslim scholars. My paper will finally discuss the historical ability of Islam in managing the heterogeneous community, and the mutual political capacity between Islam and the Eastern world.