Yıl: 2011 Cilt: 23 Sayı: 4 Sayfa Aralığı: 153 - 159 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients

Öz:
Amaç: Ameliyat öncesi uygulanan tek doz deksketoprofen trometamol ile parasetamolün laminektomi sonrası 24 saatlik dönemde postoperatif ağrı ve opioid tüketimi üzerine etkisinin randomize, çift kör, plasebo-kontrollü çalışma olarak araştırılması amaçlandı. Gereç ve Yöntem: Elektif tek seviye lomber disk cerrahisi geçirecek ASA I-II grubundan 75 hasta çalışmaya dahil edildi. Hastalar rastgele 3 gruba ayrıldı. Grup D: anestezi indüksiyonundan 30 dk önce oral 25 mg deksketoprofen, Grup P: anestezi indüksiyonundan 30 dk önce oral 500 mg parasetamol ve Grup C: anestezi indüksiyonundan 30 dk önce oral plasebo tablet uygulaması sonrasında standard genel anestezi verilen tüm hastalara ameliyat sonrasında HKA ile iv morfin başlandı. Üç grubun hemodinamik verileri, postoperatif ağrı durumu (VAS), sedasyon düzeyi, morfin tüketimi ve yan etkileri ilk 1 saatte her 15 dakikada bir, sonrasında 2., 6. ve 24. saatlerde karşılaştırıldı. Bulgular: Gruplar arasında ortalama VAS skorları arasında anlamlı fark gözlenmedi(p>0.05). 24 saatlik toplam morfin tüketimi Grup D, P ve C'de sırasıyla 28.1 mg, 40.6 mg ve 43.6 mg idi. Grup D'de tüketilen morfin miktarı 2., 6. ve 24. saatlerde anlamlı olarak düşük bulundu (p<0,006). Hemodinamik bulgular, sedasyon skorları ve yan etkiler gruplar arasında benzer bulundu (p>0.05). Sonuç: Çalışmamızın sonucunda, elektif lomber disk ameliyatlarında preemptif 25 mg deksketoprofen trometamol uygulamasının plaseboya kıyasla postoperatif morfin tüketiminde % 35'lere varan azalma sağladığı, ancak parasetamolün bu açıdan beklenen etkinliği göstermediği kanaatine varıldı.
Anahtar Kelime:

Konular: Cerrahi

Laminektomilerde preoperatif uygulanan deksketoprofenin postoperatif ağrı ve morfin tüketimi üzerine etkilerinin parasetamol ile karşılaştırılması

Öz:
Objectives: The aim of this prospective randomized, double-blind study was to evaluate the analgesic efficacy and opioid-sparing effects of preemptive single dose of dexketoprofen trometamol, in comparison with that of paracetamol or placebo, for elective lumbar disc surgery, over a 24 h investigation period. Methods: After institutional approval and informed consent had been obtained, 75 patients scheduled for single level lumbar disc surgery were randomly allocated into three equal groups. Patients received oral dexketoprofen 25 mg (group D), 500 mg paracetamol (group P) or placebo tablets (group C) 30 min before induction of standard anesthesia. Patient-controlled analgesia was supplied postoperatively using morphine. Hemodynamics, visual analog scale (VAS), sedation score, morphine consumption and side effects were recorded at every 15 min in the first hour, and 2, 6 and 24 h after surgery. Results: The mean pain scores were similar among groups (p>0.05). The cumulative (SD) 24-hour morphine consumption was 28.1 mg, 40.6 mg, and 43.6 mg for groups D, P and C, respectively. The amount of morphine use at 2, 6 and 24 h was significantly lower in Group D (p<0,006). Hemodynamic parameters, sedation scores and side-effects did not differ among the groups (p>0.05). Conclusion: The study demonstrates preemptive dexketoprofen trometamol 25 mg is associated with a decrease of up to 35% in morphine consumption compared with placebo over 24 hours following lumbar disc surgery, however, paracetamol 500 mg does not show an expected opioid sparing effect comparatively.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA kesimci e, GÜMÜŞ T, Izdes S, ŞEN P, KANBAK O (2011). Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. , 153 - 159.
Chicago kesimci elvin,GÜMÜŞ Tülin,Izdes Seval,ŞEN Pelin,KANBAK Orhan Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. (2011): 153 - 159.
MLA kesimci elvin,GÜMÜŞ Tülin,Izdes Seval,ŞEN Pelin,KANBAK Orhan Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. , 2011, ss.153 - 159.
AMA kesimci e,GÜMÜŞ T,Izdes S,ŞEN P,KANBAK O Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. . 2011; 153 - 159.
Vancouver kesimci e,GÜMÜŞ T,Izdes S,ŞEN P,KANBAK O Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. . 2011; 153 - 159.
IEEE kesimci e,GÜMÜŞ T,Izdes S,ŞEN P,KANBAK O "Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients." , ss.153 - 159, 2011.
ISNAD kesimci, elvin vd. "Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients". (2011), 153-159.
APA kesimci e, GÜMÜŞ T, Izdes S, ŞEN P, KANBAK O (2011). Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. Ağrı, 23(4), 153 - 159.
Chicago kesimci elvin,GÜMÜŞ Tülin,Izdes Seval,ŞEN Pelin,KANBAK Orhan Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. Ağrı 23, no.4 (2011): 153 - 159.
MLA kesimci elvin,GÜMÜŞ Tülin,Izdes Seval,ŞEN Pelin,KANBAK Orhan Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. Ağrı, vol.23, no.4, 2011, ss.153 - 159.
AMA kesimci e,GÜMÜŞ T,Izdes S,ŞEN P,KANBAK O Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. Ağrı. 2011; 23(4): 153 - 159.
Vancouver kesimci e,GÜMÜŞ T,Izdes S,ŞEN P,KANBAK O Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients. Ağrı. 2011; 23(4): 153 - 159.
IEEE kesimci e,GÜMÜŞ T,Izdes S,ŞEN P,KANBAK O "Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients." Ağrı, 23, ss.153 - 159, 2011.
ISNAD kesimci, elvin vd. "Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients". Ağrı 23/4 (2011), 153-159.