Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women

Ünal, Orhan; PİRİMOĞLU, Meltem; KARS, Bülent; TURAN, Cem; ESİM BÜYÜKBAYRAK, ESRA; KARAGEYİM KARŞIDAĞ, AYŞE YASEMİN; KARŞIDAĞ, Çağatay

Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women

Çağatay KARŞIDAĞ, (Bakırköy Ruh Sağlığı ve Sinir Hastalıkları Eğitim ve Araştırma Hastanesi, 1. Psikiyatri Kliniği, İstanbul, Türkiye)

Ayşe Yasemin KARAGEYİM KARŞIDAĞ, (Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Kadın Doğum Kliniği, Polikliniği, İstanbul, Türkiye)

Esra ESİM BÜYÜKBAYRAK, (Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Kadın Doğum Kliniği, Polikliniği, İstanbul, Türkiye)

Bülent KARS, (Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Kadın Doğum Kliniği, Polikliniği, İstanbul, Türkiye)

Meltem PİRİMOĞLU, (Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Kadın Doğum Kliniği, Polikliniği, İstanbul, Türkiye)

Orhan ÜNAL, (Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Kadın Doğum Kliniği, Polikliniği, İstanbul, Türkiye)

Cem TURAN (Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Kadın Doğum Kliniği, Polikliniği, İstanbul, Türkiye)

Nöropsikiyatri Arşivi

7 0

Yıl: 2012 Cilt: 49 Sayı: 1 Sayfa Aralığı: 39 - 43 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women

Öz:

Amaç: Semptomatik doğal menopoz dönemindeki kadınlarda iki farklı hormon tedavisinin etkileri ile control grubunda menopoz, depresyon ve anksiyete belirtilerinin karşılaştırılması amaçlanmıştır. Yöntemler: Yüz seksen üç hasta çalışmayı tamamladı. I. Gruptaki hastalar oral noretisteron asetat ve transdermal östradiol ile tedavi edildiler. II. Gruptaki hastalar oral noretisteron ve östradiol hemihidrat kombinasyonu ile tedavi edildiler. III. Gruptaki hastalar (control grubu) placebo uygulandı. Tedavi protokolü tüm gruplarda 3 ay uygulandı. Hastaların menopozal, depresyon ve anksiyete belirtileri tedavinin başında ve tedavinin sonunda Kupperman Ölçeği, Hamilton Depresyon Ölçeği ve Beck Anksiyete Ölçeği ile değerlendirildi. Bulgular: Üç aylık tedavi süresinin sonunda tüm gruplarda menopoz, depresyon ve anksiyete belirtilerinin anlamlı ölçüde azaldığı (p<0,001) gözlendi. Tedavinin başlangıcı ve sonunda zamana göre üç grubunun tüm değerlerini karşılaştırdığımızda I ve II grubun değerlerinin III. gruba gore daha İyi olduğu bulundu (p< 0,001). Sonuç: Trandermal veya oral östradiol ile noretisteron kombinasyonu, semptomatik doğal menopozlu kadınlarda menopoz ve depresyon ve anksiyete değerlerini iyileştirmektedir.

Anahtar Kelime:

Konular: Nörolojik Bilimler Psikiyatri

Semptomatik postmenopozal kadınlarda iki farklı hormon terapisinin ruhsal durum üzerine etkilerinin karşılaştırılması

Öz:

Objective: To investigate the effects of two different hormone therapies on menopausal symptoms, depression and anxiety scores in women with symptomatic natural menopause.Methods: 183 patients completed the study. Group I patients were treated with transdermal estradiol and oral norethisterone acetate. Group II patients were treated with oral continuous combination of norethisterone and estradiol hemihydrate. Group III (control group) patients were administered placebo. The treatment protocols were used for three months in all groups. Menopausal, depression and anxiety symptoms of the patients were assessed using the Kupperman scale, Hamilton Depression Rating Scale (HDRS) and the Beck Anxiety Inventory (BAI) before and at the end of treatment.Results: Significant improvement was observed in menopausal symptoms, depression and anxiety scores in all groups at the end of three months of therapy (p<0.001). When the three groups were compared for all parameters before and after treatment, groups I and II showed better results than group III (p≤0.001). Conclusion : Transdermal or oral estradiol in combination with norethisterone improves scores of menopausal, depression and anxiety symptoms in women with symptomatic natural menopause.

Anahtar Kelime:

Konular: Nörolojik Bilimler Psikiyatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARŞIDAĞ Ç, KARAGEYİM KARŞIDAĞ A, ESİM BÜYÜKBAYRAK E, KARS B, PİRİMOĞLU M, Ünal O, TURAN C (2012). Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. , 39 - 43.
Chicago	KARŞIDAĞ Çağatay,KARAGEYİM KARŞIDAĞ AYŞE YASEMİN,ESİM BÜYÜKBAYRAK ESRA,KARS Bülent,PİRİMOĞLU Meltem,Ünal Orhan,TURAN Cem Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. (2012): 39 - 43.
MLA	KARŞIDAĞ Çağatay,KARAGEYİM KARŞIDAĞ AYŞE YASEMİN,ESİM BÜYÜKBAYRAK ESRA,KARS Bülent,PİRİMOĞLU Meltem,Ünal Orhan,TURAN Cem Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. , 2012, ss.39 - 43.
AMA	KARŞIDAĞ Ç,KARAGEYİM KARŞIDAĞ A,ESİM BÜYÜKBAYRAK E,KARS B,PİRİMOĞLU M,Ünal O,TURAN C Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. . 2012; 39 - 43.
Vancouver	KARŞIDAĞ Ç,KARAGEYİM KARŞIDAĞ A,ESİM BÜYÜKBAYRAK E,KARS B,PİRİMOĞLU M,Ünal O,TURAN C Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. . 2012; 39 - 43.
IEEE	KARŞIDAĞ Ç,KARAGEYİM KARŞIDAĞ A,ESİM BÜYÜKBAYRAK E,KARS B,PİRİMOĞLU M,Ünal O,TURAN C "Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women." , ss.39 - 43, 2012.
ISNAD	KARŞIDAĞ, Çağatay vd. "Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women". (2012), 39-43.

APA	KARŞIDAĞ Ç, KARAGEYİM KARŞIDAĞ A, ESİM BÜYÜKBAYRAK E, KARS B, PİRİMOĞLU M, Ünal O, TURAN C (2012). Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. Nöropsikiyatri Arşivi, 49(1), 39 - 43.
Chicago	KARŞIDAĞ Çağatay,KARAGEYİM KARŞIDAĞ AYŞE YASEMİN,ESİM BÜYÜKBAYRAK ESRA,KARS Bülent,PİRİMOĞLU Meltem,Ünal Orhan,TURAN Cem Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. Nöropsikiyatri Arşivi 49, no.1 (2012): 39 - 43.
MLA	KARŞIDAĞ Çağatay,KARAGEYİM KARŞIDAĞ AYŞE YASEMİN,ESİM BÜYÜKBAYRAK ESRA,KARS Bülent,PİRİMOĞLU Meltem,Ünal Orhan,TURAN Cem Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. Nöropsikiyatri Arşivi, vol.49, no.1, 2012, ss.39 - 43.
AMA	KARŞIDAĞ Ç,KARAGEYİM KARŞIDAĞ A,ESİM BÜYÜKBAYRAK E,KARS B,PİRİMOĞLU M,Ünal O,TURAN C Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. Nöropsikiyatri Arşivi. 2012; 49(1): 39 - 43.
Vancouver	KARŞIDAĞ Ç,KARAGEYİM KARŞIDAĞ A,ESİM BÜYÜKBAYRAK E,KARS B,PİRİMOĞLU M,Ünal O,TURAN C Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women. Nöropsikiyatri Arşivi. 2012; 49(1): 39 - 43.
IEEE	KARŞIDAĞ Ç,KARAGEYİM KARŞIDAĞ A,ESİM BÜYÜKBAYRAK E,KARS B,PİRİMOĞLU M,Ünal O,TURAN C "Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women." Nöropsikiyatri Arşivi, 49, ss.39 - 43, 2012.
ISNAD	KARŞIDAĞ, Çağatay vd. "Comparison of effects of two different hormone therapies on mood in symptomatic postmenopausal women". Nöropsikiyatri Arşivi 49/1 (2012), 39-43.