A 54 years old female patient, presenting with psychiatric symptoms, after which corpus callosum infarct was detected is presented with the clinical, laboratory and radiological findings here. The patient, who did not have any psychiatric complaints before was evaluated because of personality changes and sleepy state starting 3 days before and disturbance in gait and speech of one day's duration. Previously she had a diagnosis of diabetes mellitus. Blood glucose was 45 mg/dL. An increase in signal intensity reciprocal to ADC in the corpus callosum was detected in cerebral diffusion magnetic resonance imaging (MRI). The psychiatric findings in this case were considered as “acute and temporary schizoid personality disorder” that may be explained by an underlying organic cause according to DSM-IV. The clinical symptoms that arise from corpus callosum abnormalities are variable. A psychiatric picture develops in approximately one thirds of the cases. On the other hand, corpus callosum infarct presenting with pure psychiatric findings are rarely observed in the literature. This case was considered interesting because of the temporal association between corpus callosum infarct and psychiatric symptoms in the context of coexistent hypoglycemia and left anterior cerebral artery occlusion.