Erdem KOÇAK
(SB Ankara Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Ankara, Türkiye)
Gülay KOÇAK
(SB Ankara Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, Ankara, Türkiye)
Tacettin ÖRNEK
(Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Pulmonoloji Anabilim Dalı, Zonguldak, Türkiye)
Hatice BAKIRTAŞ
(SB Ankara Atatürk Eğitim ve Araştırma Hastanesi, Pulmonoloji Kliniği, Ankara, Türkiye)
Hulusi ATMACA
(Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Samsun, Türkiye)
MURAT CAN
(Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Zonguldak, Türkiye)
TANER BAYRAKTAROĞLU
(Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Zonguldak, Türkiye)
Remzi ALTIN
(Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Pulmonoloji Anabilim Dalı, Zonguldak, Türkiye)
Yıl: 2011Cilt: 8Sayı: 4ISSN: 1304-3889 / 1304-3897Sayfa Aralığı: 273 - 279İngilizce

115 4
Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome
Amaç: Bu çalışmanın amacı obstrüktif uyku apne sendromu (OUAS) olan hastalarda insülin rezistansı ve serum leptin seviyelerini incelemek ve OUAS olan hastaların vücut kitle indeksini (VCİ) kontrol grubuyla karşılaştırmaktır. Metod: Apne hipopne indeksi (AHİ)≥5 olan 28 hasta çalışmaya dahil edildi. Sağlıklı 32 birey kontrol grubu olarak kullanıldı. Çalışmaya katılan bireylerden glukoz, insülin ve leptin seviyelerini ölçmek için açlık durumunda venöz kan elde edildi. İnsülin rezistans indeksinde, hemostaz modeli analiz methodu (HOMA-IR) temel alındı. Bulgular: OUAS grubu ile kontrol grubu arasında serum leptin seviyeleri (kontrol grubu, 32.88 ± 24.22 ng/ml, OUAS grubu, 24.93 ± 25.84 ng/ml) ve HOMA-IR (kontrol grubu, 3.01 ± 1.81, OUAS grubu, 2.58 ± 1.21) açısından anlamlı bir fark yoktu. OUAS olan hastalarda insülin rezistansı ve plazma leptin konsantrasyonları AHİ’den bağımsızdı ve kontrol grubundan farklı değildi. Sonuç: İnsülin rezistansı ve plazma leptin konsantrasyonları sıklıkla VKİ ve obesitenin derecesiyle ilişkili olduğunu düşünüyoruz. Bu parametreler OUAS olan hastalarda AHİ ile ilişkili olmadığı gözükmektedr.
Fen > Tıp > Cerrahi
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