Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome

CAN, Murat; ATMACA, Hulusi; BAKIRTAŞ, Hatice; ALTIN, Remzi; ÖRNEK, Tacettin; KOÇAK, Gülay; BAYRAKTAROĞLU, TANER; koçak, erdem

Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome

Erdem KOÇAK, (SB Ankara Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Ankara, Türkiye)

Gülay KOÇAK, (SB Ankara Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, Ankara, Türkiye)

Tacettin ÖRNEK, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Pulmonoloji Anabilim Dalı, Zonguldak, Türkiye)

Hatice BAKIRTAŞ, (SB Ankara Atatürk Eğitim ve Araştırma Hastanesi, Pulmonoloji Kliniği, Ankara, Türkiye)

Hulusi ATMACA, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Samsun, Türkiye)

Murat CAN, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Zonguldak, Türkiye)

Taner BAYRAKTAROĞLU, (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Zonguldak, Türkiye)

Remzi ALTIN (Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Pulmonoloji Anabilim Dalı, Zonguldak, Türkiye)

European Journal of General Medicine

2 1

Yıl: 2011 Cilt: 8 Sayı: 4 Sayfa Aralığı: 273 - 279 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome

Öz:

Amaç: Bu çalışmanın amacı obstrüktif uyku apne sendromu (OUAS) olan hastalarda insülin rezistansı ve serum leptin seviyelerini incelemek ve OUAS olan hastaların vücut kitle indeksini (VCİ) kontrol grubuyla karşılaştırmaktır. Metod: Apne hipopne indeksi (AHİ)≥5 olan 28 hasta çalışmaya dahil edildi. Sağlıklı 32 birey kontrol grubu olarak kullanıldı. Çalışmaya katılan bireylerden glukoz, insülin ve leptin seviyelerini ölçmek için açlık durumunda venöz kan elde edildi. İnsülin rezistans indeksinde, hemostaz modeli analiz methodu (HOMA-IR) temel alındı. Bulgular: OUAS grubu ile kontrol grubu arasında serum leptin seviyeleri (kontrol grubu, 32.88 ± 24.22 ng/ml, OUAS grubu, 24.93 ± 25.84 ng/ml) ve HOMA-IR (kontrol grubu, 3.01 ± 1.81, OUAS grubu, 2.58 ± 1.21) açısından anlamlı bir fark yoktu. OUAS olan hastalarda insülin rezistansı ve plazma leptin konsantrasyonları AHİ’den bağımsızdı ve kontrol grubundan farklı değildi. Sonuç: İnsülin rezistansı ve plazma leptin konsantrasyonları sıklıkla VKİ ve obesitenin derecesiyle ilişkili olduğunu düşünüyoruz. Bu parametreler OUAS olan hastalarda AHİ ile ilişkili olmadığı gözükmektedr.

Anahtar Kelime:

Konular: Cerrahi

Obstrüktif uyku apne sendromu olan erkek hastalarda insülin rezistansı ve serum leptin seviyeleri

Öz:

Aim: The aim of this study was to assess the insulin resistance and serum leptin levels in patients with obstructive sleep apnea syndrome (OSAS), and to compare body mass indexes (BMI) of OSAS patients with matched controls without OSAS. Method: Twenty eight patients having apnea-hypopnea index (AHI)≥5 included in the study. Thirty two healthy subjects assumed as a control group. Venous blood was obtained in the fasting state for the measurement of glucose, insulin and leptin levels. Insulin resistance index was based on the homeostasis model assesment method (HOMA-IR). Result: There was no significant difference in the serum leptin levels (control group, 32.88±24.22 ng/ml, OSAS group, 24.93±25.84 ng/ml) and HOMA-IR (control group, 3.01±1.81, OSAS group, 2.58±1.21) between control group and OSAS patients. Insulin resistance and circulating plasma leptin concentrations in OSAS patients were independent of the AHI and were not different from the control group. Conclusion: We concluded that insulin resistance and plasma leptin concentrations are mostly associated with the degree of obesity and BMI. Those parameters seem not to be related with the AHI in OSAS patients.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	koçak e, KOÇAK G, ÖRNEK T, BAKIRTAŞ H, ATMACA H, CAN M, BAYRAKTAROĞLU T, ALTIN R (2011). Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. , 273 - 279.
Chicago	koçak erdem,KOÇAK Gülay,ÖRNEK Tacettin,BAKIRTAŞ Hatice,ATMACA Hulusi,CAN Murat,BAYRAKTAROĞLU TANER,ALTIN Remzi Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. (2011): 273 - 279.
MLA	koçak erdem,KOÇAK Gülay,ÖRNEK Tacettin,BAKIRTAŞ Hatice,ATMACA Hulusi,CAN Murat,BAYRAKTAROĞLU TANER,ALTIN Remzi Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. , 2011, ss.273 - 279.
AMA	koçak e,KOÇAK G,ÖRNEK T,BAKIRTAŞ H,ATMACA H,CAN M,BAYRAKTAROĞLU T,ALTIN R Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. . 2011; 273 - 279.
Vancouver	koçak e,KOÇAK G,ÖRNEK T,BAKIRTAŞ H,ATMACA H,CAN M,BAYRAKTAROĞLU T,ALTIN R Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. . 2011; 273 - 279.
IEEE	koçak e,KOÇAK G,ÖRNEK T,BAKIRTAŞ H,ATMACA H,CAN M,BAYRAKTAROĞLU T,ALTIN R "Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome." , ss.273 - 279, 2011.
ISNAD	koçak, erdem vd. "Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome". (2011), 273-279.

APA	koçak e, KOÇAK G, ÖRNEK T, BAKIRTAŞ H, ATMACA H, CAN M, BAYRAKTAROĞLU T, ALTIN R (2011). Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. European Journal of General Medicine, 8(4), 273 - 279.
Chicago	koçak erdem,KOÇAK Gülay,ÖRNEK Tacettin,BAKIRTAŞ Hatice,ATMACA Hulusi,CAN Murat,BAYRAKTAROĞLU TANER,ALTIN Remzi Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. European Journal of General Medicine 8, no.4 (2011): 273 - 279.
MLA	koçak erdem,KOÇAK Gülay,ÖRNEK Tacettin,BAKIRTAŞ Hatice,ATMACA Hulusi,CAN Murat,BAYRAKTAROĞLU TANER,ALTIN Remzi Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. European Journal of General Medicine, vol.8, no.4, 2011, ss.273 - 279.
AMA	koçak e,KOÇAK G,ÖRNEK T,BAKIRTAŞ H,ATMACA H,CAN M,BAYRAKTAROĞLU T,ALTIN R Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. European Journal of General Medicine. 2011; 8(4): 273 - 279.
Vancouver	koçak e,KOÇAK G,ÖRNEK T,BAKIRTAŞ H,ATMACA H,CAN M,BAYRAKTAROĞLU T,ALTIN R Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome. European Journal of General Medicine. 2011; 8(4): 273 - 279.
IEEE	koçak e,KOÇAK G,ÖRNEK T,BAKIRTAŞ H,ATMACA H,CAN M,BAYRAKTAROĞLU T,ALTIN R "Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome." European Journal of General Medicine, 8, ss.273 - 279, 2011.
ISNAD	koçak, erdem vd. "Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome". European Journal of General Medicine 8/4 (2011), 273-279.