Yıl: 2012 Cilt: 39 Sayı: 3 Sayfa Aralığı: 325 - 330 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Öz:
Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir. Çalışmanın amacı BH’nda osteoprotegerin ve tümor nekroz faktör (TNF-α) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır. Gereç ve yöntem: Çalışmaya, hasta grubu ve kontrol grubu olarak iki grup alındı. TNF-α, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi (KMD) ölçüldü ve iki grup karşılaştırıldı. Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36 hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.26±11.64 ve 41.66±70.99 bulundu. Vücut kitle indeksi yönünden iki grup arasında fark bulunmadı. TNF-α (p<0.001), deokspiridinolin (p<0.001) ve osteokalsin (p=0.041) düzeyleri kontrol grubundan önemli oranda yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda düşüktü ancak anlamlı düzeyde değildi (p>0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grubunda kontrol grubuna göre anlamlı yüksekti (p=0.03). Hasta grubun KMD ölçümü; L2-L4 hariç, kontrol grubuna göre anlamlı oranda düşüktü (sırasıyla p<0.001, p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 ve p=0.111). TNF-α ve osteoprotegerin arasında korelasyon saptanmadı. Sonuç: Bu çalışmada TNF-α ve KMD arasında negatif korelasyon saptandı ve TNF-α’nın, BH’da osteoporotik süreci etkilediği bulundu. Osteoprotogerin düzeyi düşüklüğü anlamlı değildi ve TNF-α ile korele değildi.
Anahtar Kelime:

Konular: Cerrahi

Behçet hastalarında serum TNF- α ve osteoprotegerin düzeyi ve kemik kitle yoğunluğu

Öz:
Objectives: Osteoporosis is commonly developed due to natural course of Behçet&#8217;s disease (BD) and therapeutic agents. It was aimed to investigate levels of osteoprotegerin and TNF-&#945; (tumor necrosis factor), and bone mineral density (BMD) and correlation between them in BD. Materials and methods: The study included two groups as the study and the control group. Serum levels of TNF-&#945;, osteoprotegerin, osteocalcine, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and urinary creatinine and deoxypyridinoline along with BMD level were evaluated and compared. Correlation between TNF-&#945; and osteoprotegerin level was investigated. Results: The study enrolled 41 BD patients and 36 agedmatched control subjects. Mean age was 42.26±11.64 and 41.66±70.99, in the study and control groups, respectively. There was no significant difference in body mass index (BMI) of subjects between groups (p>0.05). Level of TNF-&#945; (p<0.001), deoxypyridinoline (p<0.001) and osteocalcine (p=0.041) was significantly higher in the study group compared to the control group. Osteoprotegerin was lower in BD patients, but the difference was not significant (p>0.05). Urinary deoxypyridinoline/ urinary creatinine ratio in patients with BD was significantly higher than those in control group (p=0.030). Patients had significantly lower BMD comparfed to the control group, except L2-L4 vertebral area (p<0.001, p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 and p=0.111, respectively). No correlation was found between TNF-&#945; and osteoprotegerin. Conclusions: The present study indicated that TNF-&#945; and BMD was negatively correlated with each other and TNF-&#945; had an effect on osteoporotic process in patients with BD. Osteoprotegerin level was not decreased, and not correlated with TNF-&#945;.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA KUTLUCAN A, TUNÇ Ş, BALTACI D, Şahin M, ÖZŞAHİN M, SÜTÇÜ R, SÜSLÜ H, ERMİŞ M (2012). Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. , 325 - 330.
Chicago KUTLUCAN Ali,TUNÇ Şevket Ercan,BALTACI Davut,Şahin Mehmet Ali,ÖZŞAHİN Mustafa,SÜTÇÜ Recep,SÜSLÜ Harun,ERMİŞ MEHMET FATİH Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. (2012): 325 - 330.
MLA KUTLUCAN Ali,TUNÇ Şevket Ercan,BALTACI Davut,Şahin Mehmet Ali,ÖZŞAHİN Mustafa,SÜTÇÜ Recep,SÜSLÜ Harun,ERMİŞ MEHMET FATİH Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. , 2012, ss.325 - 330.
AMA KUTLUCAN A,TUNÇ Ş,BALTACI D,Şahin M,ÖZŞAHİN M,SÜTÇÜ R,SÜSLÜ H,ERMİŞ M Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. . 2012; 325 - 330.
Vancouver KUTLUCAN A,TUNÇ Ş,BALTACI D,Şahin M,ÖZŞAHİN M,SÜTÇÜ R,SÜSLÜ H,ERMİŞ M Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. . 2012; 325 - 330.
IEEE KUTLUCAN A,TUNÇ Ş,BALTACI D,Şahin M,ÖZŞAHİN M,SÜTÇÜ R,SÜSLÜ H,ERMİŞ M "Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease." , ss.325 - 330, 2012.
ISNAD KUTLUCAN, Ali vd. "Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease". (2012), 325-330.
APA KUTLUCAN A, TUNÇ Ş, BALTACI D, Şahin M, ÖZŞAHİN M, SÜTÇÜ R, SÜSLÜ H, ERMİŞ M (2012). Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. Dicle Tıp Dergisi, 39(3), 325 - 330.
Chicago KUTLUCAN Ali,TUNÇ Şevket Ercan,BALTACI Davut,Şahin Mehmet Ali,ÖZŞAHİN Mustafa,SÜTÇÜ Recep,SÜSLÜ Harun,ERMİŞ MEHMET FATİH Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. Dicle Tıp Dergisi 39, no.3 (2012): 325 - 330.
MLA KUTLUCAN Ali,TUNÇ Şevket Ercan,BALTACI Davut,Şahin Mehmet Ali,ÖZŞAHİN Mustafa,SÜTÇÜ Recep,SÜSLÜ Harun,ERMİŞ MEHMET FATİH Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. Dicle Tıp Dergisi, vol.39, no.3, 2012, ss.325 - 330.
AMA KUTLUCAN A,TUNÇ Ş,BALTACI D,Şahin M,ÖZŞAHİN M,SÜTÇÜ R,SÜSLÜ H,ERMİŞ M Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. Dicle Tıp Dergisi. 2012; 39(3): 325 - 330.
Vancouver KUTLUCAN A,TUNÇ Ş,BALTACI D,Şahin M,ÖZŞAHİN M,SÜTÇÜ R,SÜSLÜ H,ERMİŞ M Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. Dicle Tıp Dergisi. 2012; 39(3): 325 - 330.
IEEE KUTLUCAN A,TUNÇ Ş,BALTACI D,Şahin M,ÖZŞAHİN M,SÜTÇÜ R,SÜSLÜ H,ERMİŞ M "Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease." Dicle Tıp Dergisi, 39, ss.325 - 330, 2012.
ISNAD KUTLUCAN, Ali vd. "Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease". Dicle Tıp Dergisi 39/3 (2012), 325-330.