Yıl: 2011 Cilt: 21 Sayı: 4 Sayfa Aralığı: 477 - 482 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study

Öz:
AMAÇ: Bu çalışmada, subaraknoid kanamada (SAK) koroid arter vazospazmının koroid pleksusta (KP) iskemik hasar yapıp yapmadığını inceledik. YÖNTEM ve GEREÇLER: Bu çalışma 30 tavşan üzerinde yapıldı. Sekizi kontrol grubu, 14’ü SAK grubu, 8 tavşan da SHAM grubu olarak kullanıldı. Koroidal arterlerin tam koroid pleksusa girdiği noktadaki kesitlerinin çapı ve volümü mikrometrik mikroskop kullanılarak ölçüldü. Koroid pleksus hücre ve villuslarının iskemik morfolojik değişiklikleri hafiften ağıra doğru şu şekilde tanımlandı: hücresel küçülme (1puan), sitoplazmik yoğunlaşma (2 puan), angulasyon (3 puan) ve villus yıkımı (4 puan). Mevcut histopatolojik bulguların 1 ile 4 arasındaki dejenerasyon kriterlerinin toplamı dejenerasyon skoru olarak tanımlandı. Sonuçlar istatistiksel olarak değerlendirildi. BULGULAR: Üç grubun koroidal arter çapı ve volümü ile dejenerasyon skoru değerleri şu şekilde bulundu. Kontrol grubunda ortalama koroidal arter çapı 120±30μm, volümü 1,080±0,650 mm3 ve dejenerasyon skoru 0 ve 1 arasında idi. SHAM grubunda ortalama koroidal arter çapı 110±20μm, volümü 0,907±0,330 mm3 ve dejenerasyon skoru 1 ve 4 arasında idi. SAK grubunda ortalama koroidal arter çapı 80±15μm, volümü 0,480±0,175 mm3 ve dejenerasyon skoru 3 ve 0 arasında idi. Sonuçta vazospazm derecesi ile KP dejenerasyonu arasında anlamlı ilişki bulundu. SONUÇ: SAK olgularında koroidal arterlerin vazospazmı değişik derecelerde koroid pleksus hasarı oluşturabilir. Beynin immün, endokrin, detoksifikasyon, termoregulasyon ve sekretuar fonksiyonlarında önemli rolü olan koroid pleksusların hasar görmesi SAK’daki kötü prognozun önemli bir sebebi olabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Yilmaz A, AYDIN M, KANAT A, ALTAŞ S, Aydin Y, ÇALIK M (2011). The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. , 477 - 482.
Chicago Yilmaz Adem,AYDIN Mehmet Dumlu,KANAT Ayhan,ALTAŞ Sare,Aydin Yunus,ÇALIK Muhammet The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. (2011): 477 - 482.
MLA Yilmaz Adem,AYDIN Mehmet Dumlu,KANAT Ayhan,ALTAŞ Sare,Aydin Yunus,ÇALIK Muhammet The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. , 2011, ss.477 - 482.
AMA Yilmaz A,AYDIN M,KANAT A,ALTAŞ S,Aydin Y,ÇALIK M The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. . 2011; 477 - 482.
Vancouver Yilmaz A,AYDIN M,KANAT A,ALTAŞ S,Aydin Y,ÇALIK M The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. . 2011; 477 - 482.
IEEE Yilmaz A,AYDIN M,KANAT A,ALTAŞ S,Aydin Y,ÇALIK M "The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study." , ss.477 - 482, 2011.
ISNAD Yilmaz, Adem vd. "The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study". (2011), 477-482.
APA Yilmaz A, AYDIN M, KANAT A, ALTAŞ S, Aydin Y, ÇALIK M (2011). The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. Turkish Neurosurgery, 21(4), 477 - 482.
Chicago Yilmaz Adem,AYDIN Mehmet Dumlu,KANAT Ayhan,ALTAŞ Sare,Aydin Yunus,ÇALIK Muhammet The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. Turkish Neurosurgery 21, no.4 (2011): 477 - 482.
MLA Yilmaz Adem,AYDIN Mehmet Dumlu,KANAT Ayhan,ALTAŞ Sare,Aydin Yunus,ÇALIK Muhammet The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. Turkish Neurosurgery, vol.21, no.4, 2011, ss.477 - 482.
AMA Yilmaz A,AYDIN M,KANAT A,ALTAŞ S,Aydin Y,ÇALIK M The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. Turkish Neurosurgery. 2011; 21(4): 477 - 482.
Vancouver Yilmaz A,AYDIN M,KANAT A,ALTAŞ S,Aydin Y,ÇALIK M The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study. Turkish Neurosurgery. 2011; 21(4): 477 - 482.
IEEE Yilmaz A,AYDIN M,KANAT A,ALTAŞ S,Aydin Y,ÇALIK M "The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study." Turkish Neurosurgery, 21, ss.477 - 482, 2011.
ISNAD Yilmaz, Adem vd. "The effect of choroidal artery vasospasm on choroid plexus ınjury in subarachnoid hemorrhage: experimental study". Turkish Neurosurgery 21/4 (2011), 477-482.