The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study

ÇAKIR, Zeynep; Aydin, Nazan; Gündoğdu, Cemal; CANSEVER, Tufan; KANAT, Ayhan; AYDIN, Mehmet Dumlu; Müslüman, Ahmet Murat; Yilmaz, Adem

The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study

Ahmet Murat MÜSLÜMAN, (Sağlık Bakanlığı, Şişli Eğitim ve Araştırma Hastanesi, Nöroşirurji, Kliniği, İstanbul, Türkiye)

Mehmet Dumlu AYDIN, (Atatürk Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Erzurum, Türkiye)

Adem YILMAZ, (Sağlık Bakanlığı, Şişli Eğitim ve Araştırma Hastanesi, Nöroşirurji, Kliniği, İstanbul, Türkiye)

Tufan CANSEVER, (Başkent Üniversitesi, İstanbul Hastanesi, Beyin Cerrahisi Bölümü, İstanbul, Türkiye)

Ayhan KANAT, (Rize Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Rize, Türkiye)

Cemal GÜNDOĞDU, (Atatürk Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Erzurum, Türkiye)

Zeynep ÇAKIR, (Atatürk Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Erzurum, Türkiye)

Nazan AYDIN (Atatürk Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Erzurum, Türkiye)

Turkish Neurosurgery

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Yıl: 2011 Cilt: 21 Sayı: 4 Sayfa Aralığı: 559 - 566 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study

Öz:

AMAÇ: Bu çalışmanın amacı, subaraknoid kanama (SAK) sonrası, glossofaringeal sinir petrozal ganglion iskemik nörodejenerasyonu ve KB dalgalanmaları arasındaki ilişkiyi belirlemektir. YÖNTEM ve GEREÇLER: Yirmi dört tavşanın kan basıncı ve kalp ritmi 20 gün boyunca günlük olarak takip edildi. Daha sonra, tüm hayvanların petrozal ganglionu histopatolojik olarak incelenmiştir. Petrozal gangliondaki normal ve apoptotik nöron yoğunluğu ile kan basıncı değerleri istatistiksel olarak karşılaştırıldı. BULGULAR: Petrozal ganglionun ortalama toplam hacmi 0,9 ± 0,34 / mm3 olarak hesaplandı. Kontrol grubunda KB düzeyi 96,1 ± 2,1 mmHg idi. Hafif hipertansiyon (HT) grubunun 116,5 ± 4mmHg ve ağır HT grubunda 128,1 ± 3,6 mmHg idi, gruplar birbirleriyle karşılaştırıldığında gruplar arasında anlamlı fark bulundu. Kontrol grubunda normal-apoptotik nöron düzeyi 11.240 ± 802/mm3-40 ± 6,3 / mm3 idi hafif HT grubunda 9730 ± 148,7/mm3 - 1560 ± 256,2/mm3 ve ağır HT grubunda 6870 ± 378,8/mm3-4240 ± 628,2/mm3. Gruplar birbirleriyle karşılaştırıldığında anlamlı fark vardı. SONUÇ: Bu çalışmada, kan basıncı değişkenliklerinin SAK’ ın petrozal ganglionda iskemik nörodejenerasyona neden olması ile açıklanabileceği görülmüştür. Bu çalışmanın sonuçları, petrozal ganglion iskemisinin hipertansiyon gelişimine potansiyel etkileri olduğunu göstermiştir. Bu bulgular yeni tedavi stratejilerinin SAK tedavisi için düşünülmesi gerektiğini göstermektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Aydin MD, Bayram E, Atalay C, Aydin N, Erdogan AR, Gundogdu C, Diyarbakirli S: The role of neuron numbers of the petrosal ganglion in the determination of bloodpressure: An experimental study. Minim Invasive Neurosurg 49: 359-361, 2006
2. Aydin MD, Bayram E, Halici Z, Aydin N, Atalay C, Ulvi H, Kotan D, Gundogdu C: Antihypertensive role of glossopharyngeal nerve stimulation bynifedipine usingas calcium channel blocking agent in hypertension: An experimental study. ArchPharm Res 32:1607-1611, 2009
3. Aydin MD, Kanat A, Yilmaz A, Cakir M, Emet M, Cakir Z, Aslan S, Altas S, Gundogdu C: The role of ischemic neurodegeneration of the nodose ganglia on cardiac arrest after subarachnoid hemorrhage: An experimental study. Exp Neurol. Sep 29. [Epub ahead of print], 2010
4. Ayer A, Antic V, Dulloo AG, Van Vliet BN, Montani JP: Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist Am J Physiol Heart Circ Physiol 293:1265-1272, 2007
5. Bederson JB, Guarino L, Germano IM: Failure of changes in cerebral perfusion pressure to account for ischemia caused by subarachnoid hemorrhage: A new experimental model. Soc Neurosci Abstr 20: 224-230, 1995
6. Berry MS, Pentreath VW: Criteria for distinguishing between monosynaptic and polysynaptic transmission. Brain Res 105: 1–20, 1976
7. Beseoglu K, Unfrau K, Steiger HJ, Hänggi D: Influence of blood pressure variability on short-term outcome in patients with subarachnoid hemorrhage. Cen Eur Neurosurg 71: 69-74, 2010
8. Bradley RM, Mistretta CM, Bates CA, Killackey HP: Transganglionic transport of HRP from the circumvallate papilla of the rat. Brain Res 361:154–161, 1985
9. Coelho EF, Ferrari MF, Ferrari JR, Maximino DR: Change in the expression of NPY receptor subtypes Y1 and Y2 in central and peripheral neurons related to the control of blood pressure in rats following experimental hypertension. Neuropeptides 38: 77–82, 2004
10. Costa C, Tozzi A, Luchetti E, Siliquini S, Belcastro V, Tantucci M, Picconi B,Ientile R, Calabresi P, Pisani F: Electrophysiological actions of zonisamide onstriatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction. Exp Neurol 221:217-224, 2010
11. D’Alecy LG, Rose CJ: Parasympathetic cholinergic control of cerebral blood flow in dogs. Circulation Res 41, 324–331, 1977
12. Drake MF: Cell death in the choroids plexus following transient forebrain global ischemia in the rat. Microscopy Research and Technique. 52: 130-136, 2001
13. Esler M: The sympathetic system and hypertension. Am J Hypertens 13: 99–105, 2000
14. Faraci FM, Heistad DD: Regulation of large cerebral arteries and cerebral microvascular pressure. Circulation Res 66, 8–17, 1990
15. Gardi JE, Nyengaard JR, Gundersen HJ: Automatic sampling for unbiased and efficient stereological estimation using the proportionator in biological studies. J Microsc 230:108-120, 2008
16. Goadsby PJ: Characteristics of facial nerve-elicited cerebral vasodilatation determined using laser Doppler flowmetry. Am J Physiol 260, 255–262, 1991
17. Gomez JC, Boyero S, Fernandez C, Sagasta A, Perez T, Velasco F, Allue I, Lezcano E, Zarranz JJ: Baroreflex failure after chemodectoma resection. Neurologia 19: 452-455, 2004
18. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96:379-394, 1988
19. Hamilton RB, Norgren R: Central projections of gustatory nerves in the rat. J Comp Neurol 222: 560–577, 1984
20. Huang FL, Zhuo H, Sinclair C, Goldstein ME, McCabe JT, Helke CJ: Peripheral deafferentation alters calcitonin gene-related peptide mRNA expression in visceral sensory neurons of the nodose and petrosal ganglia. Brain Res 22, 290-298, 1994
21. Ichikawa H, Sugimoto T: Co-expression of VRL-1 and calbindin D- 28 k in the rat sensory ganglia. Brain Res 924:109–112, 2002
22. Leila M, Bianchi S, Leda MO, Anette H: Baroreceptor control of heart rate in the awake toad: Peripheral autonomiceffectors and arterial baroreceptor areas. Journal of the Autonomic Nervous System 80: 31–39, 2000
23. Mustonen T, Koivisto T, Vanninen R, Hänninen T, Vapalahti M, Hernesniemi J, Kuikka JT, Vanninen E: Heterogeneity of cerebral perfusion 1 week after haemorrhage is an independent predictor of clinical outcome in patients with aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 79:1128-1133, 2008
24. Oubina MP, de Las Heras N, Vazquez-Perez S, Cediel E, Sanz- Rosa D, Ruilope LM, Cachofeiro V, Lahera V: Valsartan improves fibrinolytic balance in atherosclerotic rabbits. J Hypertens 20: 303-310, 1988
25. Raszkiewicz JL, Linville DG, Kerwin JF, Wagenaar F, Arneric SP: Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation. J Neurosci Res 33:129–135, 1992
26. Ryttlefors M, Howells T, Nilsson P, Ronne-Engtröm E, Enblad P: Secondary insults in subarachnoid hemorrhage: Occurence and impact on outcome and clinical deterioration. Neurosurgery 61: 704-714, 2007
27. Sabri M, Kawashima A, Ai J, Macdonald RL: Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: Apossible cause for poor prognosis. Brain Res 31:163-171, 2008
28. Salar G, Ori C, Baratto V, Iob I, Mingrino S: Selective percutaneous thermolesions of the ninth cranial nerve by lateral cervical approach: report of eight cases. Surg Neurol 20:276-279, 1983
29. Sterio DC: The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc 134:127-136, 1984
30. Suzuki N, Hardebo JE, Kahrstrom J and Owman C: Selective electrical stimulation of postganglionic cerebrovascular nerve fibers originating from the sphenopalatine ganglion enhances cortical blood flow in the rat. J Cerebr Blood Flow Metab 10:383–391, 1990
31. Tabuchi S, Hirano N, Tanabe M, Akatsuka K, Watanabe T: An abrupt fall in blood pressure in aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl 104: 373-376, 2008
32. Tenenbaum T, Essmann F, Adam R, Seibt A, Jänicke RU, Novotny GE, Galla HJ, Schroten H: Cell death, caspase activation, and HMGB1 release of porcine choroid plexus epithelial cells during Streptococcus suis infection in vitro. Brain Res 19:1-12, 2006
33. Toda N, Tanaka T, Ayajiki K, Okamura T: Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys Neuroscience 96 :393-398, 2000
34. Whitehead MC: Anatomy of the gustatory system in the hamster: Synaptology of facial afferent terminals in the solitary nucleus. J Comp Neurol 244: 72–85, 1986
35. William WB: Lower brainstem regulation of visceral, cardiovascular, and respiratory functions. In: Paxinos G, ed. The Human Nervous System. 2nd Ed. California: Elsevier Academic Press, 2003: 464-478

APA	Müslüman A, AYDIN M, Yilmaz A, CANSEVER T, KANAT A, Gündoğdu C, ÇAKIR Z, Aydin N (2011). The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. , 559 - 566.
Chicago	Müslüman Ahmet Murat,AYDIN Mehmet Dumlu,Yilmaz Adem,CANSEVER Tufan,KANAT Ayhan,Gündoğdu Cemal,ÇAKIR Zeynep,Aydin Nazan The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. (2011): 559 - 566.
MLA	Müslüman Ahmet Murat,AYDIN Mehmet Dumlu,Yilmaz Adem,CANSEVER Tufan,KANAT Ayhan,Gündoğdu Cemal,ÇAKIR Zeynep,Aydin Nazan The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. , 2011, ss.559 - 566.
AMA	Müslüman A,AYDIN M,Yilmaz A,CANSEVER T,KANAT A,Gündoğdu C,ÇAKIR Z,Aydin N The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. . 2011; 559 - 566.
Vancouver	Müslüman A,AYDIN M,Yilmaz A,CANSEVER T,KANAT A,Gündoğdu C,ÇAKIR Z,Aydin N The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. . 2011; 559 - 566.
IEEE	Müslüman A,AYDIN M,Yilmaz A,CANSEVER T,KANAT A,Gündoğdu C,ÇAKIR Z,Aydin N "The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study." , ss.559 - 566, 2011.
ISNAD	Müslüman, Ahmet Murat vd. "The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study". (2011), 559-566.

APA	Müslüman A, AYDIN M, Yilmaz A, CANSEVER T, KANAT A, Gündoğdu C, ÇAKIR Z, Aydin N (2011). The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. Turkish Neurosurgery, 21(4), 559 - 566.
Chicago	Müslüman Ahmet Murat,AYDIN Mehmet Dumlu,Yilmaz Adem,CANSEVER Tufan,KANAT Ayhan,Gündoğdu Cemal,ÇAKIR Zeynep,Aydin Nazan The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. Turkish Neurosurgery 21, no.4 (2011): 559 - 566.
MLA	Müslüman Ahmet Murat,AYDIN Mehmet Dumlu,Yilmaz Adem,CANSEVER Tufan,KANAT Ayhan,Gündoğdu Cemal,ÇAKIR Zeynep,Aydin Nazan The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. Turkish Neurosurgery, vol.21, no.4, 2011, ss.559 - 566.
AMA	Müslüman A,AYDIN M,Yilmaz A,CANSEVER T,KANAT A,Gündoğdu C,ÇAKIR Z,Aydin N The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. Turkish Neurosurgery. 2011; 21(4): 559 - 566.
Vancouver	Müslüman A,AYDIN M,Yilmaz A,CANSEVER T,KANAT A,Gündoğdu C,ÇAKIR Z,Aydin N The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. Turkish Neurosurgery. 2011; 21(4): 559 - 566.
IEEE	Müslüman A,AYDIN M,Yilmaz A,CANSEVER T,KANAT A,Gündoğdu C,ÇAKIR Z,Aydin N "The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study." Turkish Neurosurgery, 21, ss.559 - 566, 2011.
ISNAD	Müslüman, Ahmet Murat vd. "The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study". Turkish Neurosurgery 21/4 (2011), 559-566.