Genetik bağlantı analizi ve uygulama alanları

KURAR, Ercan; ÖZŞENSOY, Yusuf

Genetik bağlantı analizi ve uygulama alanları

Yusuf ÖZŞENSOY, (Bitlis Eren Üniversitesi, Sağlık Yüksek Okulu, Bitlis, Türkiye)

Ercan KURAR (Selçuk Üniversitesi, Veteriner Fakültesi, Genetik Anabilim Dalı, Konya, Türkiye)

Erciyes Üniversitesi Veteriner Fakültesi Dergisi

16 2

Yıl: 2013 Cilt: 10 Sayı: 1 Sayfa Aralığı: 53 - 62 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Genetik bağlantı analizi ve uygulama alanları

Öz:

Sirke sinekleri (Drosophilia melanogaster) üzerinde yapılan çalışmalarda, bazı özelliklerinin kalıtımının Mendel Kanunlarına uymadığı ve genlerin kromozomlar üzerinde bileşik olabileceği belirlenmiştir. Dolayısıyla, genetik linkage (bağlantı) kavramı ve ilk genetik bağlantı haritası başarıyla ilk kez ortaya konulmuştur. Gen haritalaması, genlerin ve markörlerin kromozomlar üzerinde bulunduğu yerlerin ve birbirlerine olan uzaklıkların tespit edilmesidir. Krossing-over olayından yararlanarak, bileşik genlerin dizilişi ve aralarındaki uzaklıkların bulunması sonucu genetik bağlantı haritaları oluşturulmaktadır. Genetik bağlantı analizi farklı uygulama alanlarına sahiptir. Bağlantı analizleri gen haritalarının oluşturulması ve türler arası karşılaştırmalı genom (comparative genomics) çalışmalarında kullanılmaktadır. Özellikle, ekonomik öneme sahip özelliklerin ve hastalıklara sebep olan gen bölgelerinin tespiti amacıyla genom tarama ve kantitatif özellik lokusları (QTL) haritalama çalışmaları ile markör destekli seleksiyon (MAS) uygulamalarının temelini oluşturmaktadır.

Anahtar Kelime:

Konular: Biyoloji

Analysis and applications of genetic linkage

Öz:

Research conducted on fruit flies (Drosophilia melanogaster) has indicated that inheritance of some characters did not follow Mendelian Laws; and genes might be linked to each other on chromosomes. Therefore, genetic linkage as a concept and the first linkage map were reported for the first time. Gene mapping terminology refers to the indication of positions of genes and markers; and the distances between them on chromosomes. Genetic linkage maps are formed by utilizing crossing-over events, following the determination of orders of the linked-genes and the distances between them. Analysis of genetic linkage provides various application possibilities. Linkage analyses are used for linkage mapping and comparative genomic analyses between species. In particular, they form the basis of the studies on genome scanning and quantitative trait loci (QTL) mapping aiming to quantify the traits that are economically important and the gene locations that cause diseases; as well as the applications of marker assisted selection (MAS).

Anahtar Kelime:

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Archibald AL, Haley CS, Brown JF, Couperwhite S, McQueen HA, Nicholson D, Coppieters W, Van de Weghe A, Stratil A, Winterø AK, Fredholm M, Larsen NJ, Nielsen VH, Milan D, Woloszyn N, Robic A, Dalens M, Riquet J, Gellin J, Caritez J-C, Burgaud G, Ollivier L, Bidanel J-P, Vaiman M, Renard C, Geldermann H, Davoli R, Ruyter D, Verstege EJM, Groenen MAM, Davies W, Høyheim B, Keiserud A, Andersson L, Ellegren H, Johansson M, Marklund L, Miller JR, Anderson Dear DV, Signer E, Jeffreys AJ, Moran C, Le Tissier P, Muladno, Rothschild MF, Tuggle CK, Vaske D, Helm J, Liu H-C, Rahman A, Yu T-P, Larson RG, Schmitz CB. The PiGMaP consortium linkage map of the pig (Sus scrofa). Mamm Genome 1995; 6(3): 15775.
2. Attwood J, Chiano M, Collins A, Donis-Keller H, Dracopoli N, Fountain J, Falk C, Goudie D, Gusella J, Haines J, Armour JAL, Jeffreys AJ, Kwiatkowski D, Lathrop M, Matise T, Northrup H, Pericak-Vance MA, Phillips J, Retief A, Robson E, Shields D, Slaugenhaupt S, Vergnaud G, Weber J, Weissenbach J, White R, Yates J, Povey S. CEPH consortium map of chromosome 9. Genomics 1994; 19(2): 203 14.
3. Barendse W, Armitage SM, Kossarek LM, Shalom A, Kirkpatrick BW, Ryan AM, Clayton D, Li L, Neibergs HL, Zhang N, Grosse WM, Weiss J, Creighton P, McCarthy F, Ron M, Teale AJ, Fries R, McGraw RA, Moore SS, Georges M, Soller M, Womack JE, Hetzel DJS. A genetic linkage map of the bovine genome. Nat Genet 1994; 6: 22735.
4. Barendse W, Armitage SM, Ryan AM, Moore SS, Clayton D, Georges M,Womack JE, Hetzel J. A genetic map of DNA loci on bovine chromosome 1. Genomics 1993; 18 (3): 6028.
5. Barendse W, Vaiman D, Kemp SJ, Sugimoto Y, Armitage SM, Williams JL, Sun HS, Eggen A, Agaba M, Aleyasin SA, Band M, Bishop MD, Buitkamp J, Byrne K, Collins F, Cooper L, Coppettiers W, Denys B, Drinkwater RD, Easterday K, Elduque C, Ennis S, Erhardt G, Ferretti L, Flavin N, Gao Q, Georges M, Gurung R, Harlizius B, Hawkins G, Hetzel J, Hirano T, Hulme D, Jorgensen C, Kessler M, Kirkpatrick BW, Konfortov B, Kostia S, Kuhn C, Lenstra JA, Leveziel H, Lewin HA, Leyhe B, Lil L, Martin Burriel I, McGraw RA, Miller JR, Moody DE, Moore SS, Nakane S, Nijman IJ, Olsaker I, Pomp D, Rando A, Ron M, Shalom A, Teale AJ, Thieven U, Urquhart BGD, Vage D-I, Van de Weghe A, Varvio S, Velmala R, Vilkki J, Weikard R, Woodside C, Womack JE, Zanotti M, Zaragoza P. A medium- density genetic linkage map of the bovine genome. Mamm Genome 1997; 8(1): 218.
6. Beckmann JS. Genetic mapping, an overview. Suhai S. Ed. In: Computational methods in Genome Research. New York: Plenum Press, 1994; pp. 7584.
7. Beever JE, Lewin HA, Barendse W, Andersson L, Armitage SM, Beattie CW, Burns BM, Davis SK, Kappes SM, Kirkpatrick BW, Ma RZ, McGraw RA, Stone RT, Taylor JF. Report of the first workshop on the genetic map of bovine chromosome 23. Anim Genet 1996; 27(2): 6975.
8. Bishop MD, Kappes SM, Keele JW, Stone RT, Sunden SLF, Hawkins GA, Toldo SS, Fries R, Grosz MD, Yoo J, Beattie CW. A genetic linkage map for cattle. Genetics 1994; 136: 61939.
9. Buetow KH, Weber JL, Ludwigsen S, Scherpbier-Heddema T, Duyk GM, Sheffield VC, Wang Z, Murray JC. Integrated human genome-wide maps constructed using the CEPH reference panel. Nat Genet 1994; 6(4): 3913.
10. Bumstead N, Palyga J. A preliminary linkage map of the chicken genome. Genomics 1992; 13(3): 6907.
11. Burt DW, Morrice DR, Sewalem A, Smith J, Paton IR, Smith EJ, Bentley J, Hocking PM. Preliminary linkage map of the turkey (Meleagris gallopavo) based on microsatellite markers. Anim Genet 2003; 34: 399409.
12. Casas E, Barendse W, Beever JE, Burns BM, Davis SK, Erhardt G, Förster M, Gomez-Raya L, Kalm E, Kappes SM, Klungland H, Lewin HA, Lien S, Olsaker I, Reinsch N, Schwerin M, Song Y, Taylor JF, Thomsen H, Våge DI, Wu X, Xu N, Yeh C-C. Bovine chromosome 4 workshop: consensus and comprehensive linkage maps. Anim Genet 1999; 30(5): 375 7.
13. Casas E, Bennett GL, Bottema CDK, Crawford A, Kalm E, Kappes SM, Kister A, Lewin HA, Lien S, Morris CA, Olsaker I, Pitchford WS, Schmutz SM, Thomsen H, Xu N. Comprehensive linkage map of bovine chromosome 11. Anim Genet 2001; 32(2): 92 4.
14. Casas E, Sonstegard TS, Barendse W, Bennett GL, Bottema CDK, Crawford A, Grosz MD, Kalm E, Kappes SM, Kister A, Li Y, Lien S, Morris CA, Olsaker I, Pitchford WS, Schmutz SM, Thomsen H, Xu N. Comprehensive linkage map of bovine chromosome 27. Anim Genet 2001; 32(2): 95- 7.
15. Cockett NE, Shay TL, Beever JE, Nielsen D, Albretsen J, Georges M, Peterson K, Stephens A, Vernon W, Timofeevskaia O, South S, Mork J, Maciulis A, Bunch TD. Localization of the locus causing Spider Lamb Syndrome to the distal end of ovine chromosome 6. Mamm Genome 1999; 10: 35 8.
16. Crawford AM, Montgomery GW, Pierson CA, Brown T, Dodds KG, Sunden SLF, Henry HM, Ede AJ, Swarbrick PA, Berryman T. Sheep linkage mapping: nineteen linkage groups derived from the analysis of paternal half-sib families. Genetics 1994; 137: 5739.
17. Dausset J, Cann H, Cohen D, Lathrop M, Lalouel JM, White R. Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome. Genomics 1990; 6(3): 5757.
18. de Gortari MJ, Freking BA, Cuthbertson RP, Kappes SM, Keele JW, Stone RT, Leymaster KA, Dodds KG, Crawford AM, Beattie CW. A second-generation linkage map of the sheep genome. Mamm Genome 1998; 9(3): 2049.
19. Dietrich W, Katz H, Lincoln SE, Shin HS, Friedman J, Dracopoli NC, Lander ES. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 1992; 131: 42347.
20. Dietrich WF, Miller JC, Steen RG, Merchant M, Damron D, Nahf R, Gross A, Joyce DC, Wessel M, Dredge RD, Marquis A, Stein LD, Goodman N, Page DC, Lander ES. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nat Genet 1994; 7: 22045.
21. Dogmap. http://www.dogmap.ch; Erişim: 27.03.2007.
22. Donis-Keller H, Green P, Helms C, Cartinhour S, Weiffenbach B, Stephens K, Keith TP, Bowden DW, Smith DR, Lander ES, Botstein D, Akots G, Rediker KS, Gravius T, Brown VA, Rising MB, Parker C, Powers JA, Watt DE, Kauffman ER, Bricker A, Phipps P, Muller -Kahle H, Fulton TR, Ng S, Schumm JW, Braman JC, Knowlton RG, Barker DF, Crooks SM, Lincoln SE, Daly MJ, Abrahamson J. A genetic linkage map of the human genome. Cell 1987; 51(2): 319-37.
23. Dracopoli NC, O'Connell P, Elsner TI, Lalouel JM, White RL, Buetow KH, Nishimura DY, Murray JC, Helms C, Mishra SK. The CEPH consortium linkage map of human chromosome 1. Genomics 1991; 9(4): 686- 700.
24. Erensayın C. Genetik. 2. Baskı. Ankara: Nobel Yayın Dağıtım, 2000; pp. 119-134.
25. Farber CR, Raney NE, Rilington VD, Venta PJ, Ernst CW. Comparative mapping of genes flanking the human chromosome 12 evolutionary breakpoint in the pig. Cytogenet Genome Res 2003; 102(1-4): 139-44.
26. Fries R, Eggen A, Womack JE. The bovine genome map. Mamm Genome 1993; 4(8): 405-28.
27. Gao Q, Womack JE. A genetic map of bovine chromosome 7 with an interspecific hybrid backcross panel. Mamm Genome 1997; 8(4): 258-61.
28. Green P, Falls K, Crooks S. Documentation for CRI-MAP, version 2.4. Washington University School of Medicine: St. Louis, MO. 1990.
29. Griffiths AJF, Wessler SR, Lewontin RC, Gelbart WM, Suzuki DT, Miller JH. Introduction to genetic analysis. 8th eds. New York: WH Freeman and Company, 2005.
30. Grobet L, Martin LJR, Poncelet D, Pirottin D, Brouwers B, Riquet J, Schoeberlein A, Dunner S, Menissier F, Massabanda J. A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nat Genet 1997; 17: 71-4.
31. Groenen MAM, Crooijmans RPMA, Veenendaal A, Cheng HH, Siwek M, van der Poel JJ. A comprehensive microsatellite linkage map of the chicken genome. Genomics 1998; 49: 265-74.
32. Gu Z, Gomez-Raya L, Våge DI, Elo K, Barendse W, Davis G, Grosz M, Erhardt G, Kalm E, Reinsch N, Kappes SM, Stone RT, Davis SK, Taylor JF, Kirkpatrick BW. Consensus and comprehensive linkage maps of bovine chromosome 7. Anim Genet 2000; 31(3): 206-9.
33. Guérin G, Bailey E, Bernoco D, Anderson I, Antczak DF, Bell K, Binns MM, Bowling AT, Brandon R, Cholewinski G, Cothran EG, Ellegren H, Förster M, Godard S, Horin P, Ketchum M, Lindgren G, McPartlan H, Mériaux J-C, Mickelson JR, Millon LV, Murray J, Neau A, Røed K, Sandberg K, Shiue Y-L, Skow LC, Stott M, Swinburne J, Valberg SJ, Van Haeringen H, Van Haeringen WA, Ziegle J. Report of the International Equine Gene Mapping Workshop: male linkage map. Anim Genet 1999; 30(5): 341-54.
34. Guérin G, Bailey E, Bernoco D, Anderson I, Antczak DF, Bell K, Biros I, Bjørnstad G, Bowling AT, Brandon R, Caetano AR, Cholewinski G, Colling D, Eggleston M, Ellis N, Flynn J, Gralak B, Hasegawa T, Ketchum M, Lindgren G, Lyons LA, Millon LV, Mariat D, Murray J, Neau A, Røed K, Sandberg K , Skow LC, Tammen I, Tozaki T, Van Dyk E, Weiss B, Young A, Ziegle J. The second generation of the International Equine Gene Mapping Workshop half-sibling linkage map. Anim Genet 2003; 34: 161-8.
35. Haldane JBS, Sprunt AD, Haldane NM. Reduplication in mice (Preliminary Communication). J Genet 1915; 5(2): 133-5.
36. Haldane JBS. Sex ratio and unisexual sterility in hybrid animals. J Genet 1922; 12: 1019.
37. Kappes SM, Keele JW, Stone RT, McGraw RA, Sonstegard TS, Smith TP, Lopez- Carrales NL, Beattie CW. A secondgeneration linkage map of the bovine genome. Genome Res 1997; 7(3): 235-49.
38. Kappes SM. Utilization of gene mapping information in livestock animals. Theriogenology 1999; 51: 135-47.
39. Kurar E, Barendse W, Bottema CDK, Davis S, Föster M, Kalm E, Kappes SM, Kister A, Lewin HA, Klungland H, Medjugorac I, Olsaker I, Pitchford WS, Schmutz SM, Taylor J, Thomsen H, Kirkpatrick BW. Consensus and comprehensive linkage maps of bovine chromosome 24. Anim Genet 2002; 33: 460- 3.
40. Lathrop GM, Lalouel JM, Julier C, Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 1984; 81: 3443-6.
41. Lathrop M, Cartwright P, Wright S, Nakamura Y, Georges M. Data analysis for linkage studies. Schook LB, Lewin HA, McLaren DG. eds. Gene-Mapping Techniques and Applications. New York: Marcel Dekker, Inc, 1991; pp. 177-97.
42. Levan KK, Ståhl F. Integrated linkage maps in the rat. Transplant Proc 1999; 31(3): 1544 5.
43. Levin I, Santangelo L, Cheng H, Crittenden LB, Dodgson JB. An autosomal genetic linkage map of the chicken. J Hered 1994; 85 (2): 79-85.
44. Lewin HA, Clamp PA, Beever JE, Schook LB. Mapping genes for resistance to infectious diseases in animals. Schook LB, Lewin HA, McLaren DG. eds. Gene-Mapping Techniques and Applications. New York: Marcel Dekker, Inc, 1991; pp. 283-303.
45. Lindgren G, Sandberg K, Persson H, Marklund S, Breen M, Sandgren B, Carlstén J, Ellegren H. A primary male autosomal linkage map of the horse genome. Genome Res 1998; 8: 951-66.
46. Liu BH. Statistical genomics. New York: CRC Press Boca Raton, 1998.
47. Ma RZ, Beever JE, Da Y, Green CA, Russ I, Park C, Heyen DW, Everts RE, Fisher SR, Overton KM, Teale AJ, Kemp SJ, Hines HC, Guérin G, Lewin HA. A male linkage map of the cattle (Bos taurus) genome. J Hered 1996; 87(4): 261-71.
48. Maddox JF, Davies KP, Crawford AM, Hulme DJ, Vaiman D, Cribiu EP, Freking BA, Beh KJ, Cockett NE, Kang N, Riffkin CD, Drinkwater R, Moore SS, Dodds KG, Lumsden JM, vab Stijn TC, Phua SH, Adelson DL, Burkin HR, Broom JE, Buitkamp J, Cambridge L, Cushwa WT, Gerard E, Galloway SM, Harrison B, Hawken RJ, Hiendleder S, Henry HM, Medrano JF, Paterson KA, Schibler L, Stone RT, van Hest B. An enhanced linkage map of the sheep genome comprising more than 1000 loci. Genome Res 2001; 11: 1275-89.
49. Mellersh CS, Langston AA, Acland GM, Fleming MA, Ray K, Wiegand NA, Francisco LV, Gibbs M, Aguirre GD, Ostrander EA. A linkage map of the canine genome. Genomics 1997; 46: 326-36.
50. Moran C, James JW. Linkage mapping. Ruvinsky A, Graves JAM. eds. In: Mammalian Genomics. CABI Publishing, 2004; pp. 1-22.
51. Morgan TH. Sex-limited inheritance in Drosophila. Science 1910; 32: 120-2.
52. Morgan TH. The application of the conception of pure lines to sex-limited inheritance and to sexual dimorphism. Am Nat 1911; 45(530): 6578.
53. Morgan TH. The theory of genes. Yale University Press: New Haven, Conn, 1928.
54. Morton NE. Sequential tests for the detection of linkage. Am J Hum Genet 1955; 7(3): 277- 318.
55. Muller HJ. The mechanism of crossing-over. Am Nat 1916; 50(592): 193-221.
56. Murray JC, Buetow KH, Weber JL, Ludwigsen S, Scherpbier-Heddema T, Manion F, Quillen J, Sheffield VC, Sunden S, Duyk GM. A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC). Science 1994; 265(5181): 2049-54.
57. Ott J. Analysis of Human Genetic Linkage. 3rd Edition (Revised Edition). Baltimore: Johns Hopkins University Pres, 1991.
58. Passarge E. Renkli genetik atlası. Çevirenler: Lüleci G, Sakızlı M, Alper Ö. İstanbul: Nobel Tıp Kitapevleri, 2000.
59. Petersen G, Johnson P, Andersson L, Klinga- Levan K, Gómez-Fabre PM, Ståhl F. RatMap -rat genome tools and data. Nucleic Acids Res 2005; database issue, 33, D492D494.
60. Pig Genome Database. http: / / www.animalgenome.org/pig/genome/db/; Erişim: 17.08.2012.
61. Ratmap. http://ratmap.gen.gu.se/; Erişim: 24.03.2007.
62. Remmers EF, Griffiths MM, Longman RE, Gulko PS, Kawahito Y, Chen S, Chang L, Shepard J, Ge L, Dracheva S, Wang JP, Joe B, Cannon GW, Wilder RL. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Transplant Proc 1999; 31: 1549-54.
63. Rhodes M, Straw R, Fernando S, Evans A, Lacey T, Dearlove A, Greystrong J, Walker J, Watson P, Weston P, Kelly M, Taylor D, Gibson K, Mundy C, Bourgade F, Poirier C, Simon D, Brunialti ALB, Montagutelli X, Guenet J-L, Haynes A, Brown SDM. A highresolution microsatellite map of the mouse genome. Genome Res 1998; 8: 531-42.
64. Riggs PK, Owens KE, Rexroad CE, Amaral MEJ, Womack JE. Development and initial characterization of a Bos taurus x B. gaurus interspecific hybrid backcross panel. J Hered 1997; 88(5): 373-9.
65. Sax K. The association of size differences with seed-coat pattern and pigmentation in Phaseolus vulgaris. Genetics 1923; 8(6): 552 -60.
66. Sh e ep Ge n ome Map. h t t p : / / www.livestockgenomics.csiro.au/sheep/ mapcreator/; Erişim: 17.08.2012.
67. Soller M. Mapping quantitative trait loci affecting traits of economic importance in animal populations using molecular markers. Schook LB, Lewin HA, McLaren DG. eds. In: Gene-Mapping Techniques and Applications. New York: Marcel Dekker, Inc, 1991; pp. 21- 49.
68. Sonstegard TS, Barendse W, Bennett GL, Brockmann GA, Davis S, Droegemuller C, Kalm E, Kappes SM, Kühn C, Li Y, Schwerin M, Taylor J, Thomsen H, van Tassell CP, Yeh CC. Consensus and comprehensive linkage maps of the bovine sex chromosomes. Anim Genet 2001; 32(2): 115-7.
69. Sonstegard TS, Bennett GL, Kalm E, Kappes SM, Lewin HA, Olsaker I, Schmutz S, Thomsen H, Vage DI, van Tassell CP, Xu N. Consensus and comprehensive linkage maps of bovine chromosome 25. Anim Genet 2001; 32(2): 114-5.
70. Sturtevant AH. The linear association of six sex-linked factors in Drosophila, as shown by their mode of association. Jour Exp Zool 1913; 14: 4359.
71. Sun HS. Comparative mapping of the human and bovine genoms with a focus on bovine chromosome 12 (human Chromosome 13). PhD Thesis. University of Wisconsin-Madison, USA, 1996.
72. Swinburne J, Gerstenberg C, Breen M, Aldridge V, Lockhart L, Marti E, Antczak D, Eggleston-Stott M, Bailey E, Mickelson J, Røed K, Lindgren G, von Haeringen W, Guérin G, Bjarnason J, Allen T, Binns M. First comprehensive low-density horse linkage map based on two 3-generation, full-sibling, Cross-Bred Horse Reference Families. Genomics 2000; 66(2): 123-34.
73. Taylor JF, Lutaaya E, Sanders JO, Turner JW, Davis SK. A medium density microsatellite map of BTA10: reassignment of INRA69. Anim Genet 1997; 28(5): 360-2.
74. Våge DI, Olsaker I, Klungland H, Gomez-Raya L, Lien S. A male genetic map designed for quantitative trait loci mapping in Norwegian Cattle. Acta Agr Scand A Anim Sci 2000; 50 (1): 56-63.
75. Vaiman D, Schibler L, Bourgeois F, Oustry A, Amiguest Y, Cribiu EP. A genetic linkage map of the male goat genome. Genetics 1996; 144: 279-305.
76. Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P, Vaysseix G, Lathrop M. A second-generation linkage map of the human genome. Nature 1992; 359 (6398): 794-801.
77. Weller JI, Fernando RL. Strategies for the improvement of animal production using Marker-Assisted Selection. Schook LB, Lewin HA, McLaren DG. eds. In: Gene-Mapping Techniques and Applications. New York: Illinois, Marcel Dekker, Inc. 1991; pp. 305-27.
78. Womack JE, Kata SR. Bovine genome mapping: evolutionary inference and the power of comparative genomics. Curr Opin Genet Dev 1995; 5: 725-33.
79. Womack JE. Strategies and technologies for comparative gene mapping. Schook LB, Lewin HA, McLaren DG. eds. In: Gene-Mapping Techniques and Applications. New York: Marcel Dekker, Inc, 1991; 3-20.

APA	ÖZŞENSOY Y, KURAR E (2013). Genetik bağlantı analizi ve uygulama alanları. , 53 - 62.
Chicago	ÖZŞENSOY Yusuf,KURAR Ercan Genetik bağlantı analizi ve uygulama alanları. (2013): 53 - 62.
MLA	ÖZŞENSOY Yusuf,KURAR Ercan Genetik bağlantı analizi ve uygulama alanları. , 2013, ss.53 - 62.
AMA	ÖZŞENSOY Y,KURAR E Genetik bağlantı analizi ve uygulama alanları. . 2013; 53 - 62.
Vancouver	ÖZŞENSOY Y,KURAR E Genetik bağlantı analizi ve uygulama alanları. . 2013; 53 - 62.
IEEE	ÖZŞENSOY Y,KURAR E "Genetik bağlantı analizi ve uygulama alanları." , ss.53 - 62, 2013.
ISNAD	ÖZŞENSOY, Yusuf - KURAR, Ercan. "Genetik bağlantı analizi ve uygulama alanları". (2013), 53-62.

APA	ÖZŞENSOY Y, KURAR E (2013). Genetik bağlantı analizi ve uygulama alanları. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 10(1), 53 - 62.
Chicago	ÖZŞENSOY Yusuf,KURAR Ercan Genetik bağlantı analizi ve uygulama alanları. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 10, no.1 (2013): 53 - 62.
MLA	ÖZŞENSOY Yusuf,KURAR Ercan Genetik bağlantı analizi ve uygulama alanları. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, vol.10, no.1, 2013, ss.53 - 62.
AMA	ÖZŞENSOY Y,KURAR E Genetik bağlantı analizi ve uygulama alanları. Erciyes Üniversitesi Veteriner Fakültesi Dergisi. 2013; 10(1): 53 - 62.
Vancouver	ÖZŞENSOY Y,KURAR E Genetik bağlantı analizi ve uygulama alanları. Erciyes Üniversitesi Veteriner Fakültesi Dergisi. 2013; 10(1): 53 - 62.
IEEE	ÖZŞENSOY Y,KURAR E "Genetik bağlantı analizi ve uygulama alanları." Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 10, ss.53 - 62, 2013.
ISNAD	ÖZŞENSOY, Yusuf - KURAR, Ercan. "Genetik bağlantı analizi ve uygulama alanları". Erciyes Üniversitesi Veteriner Fakültesi Dergisi 10/1 (2013), 53-62.