Objective: Acute upper gastrointestinal (GI) bleeding is a common medical emergency and a major cause of morbidity and mortality. In the present study, we aimed to investigate etiological and epidemiological character-ristics of non-variceal upper gastrointestinal bleeding. Material and Method: We evaluated the records of 108 patients (74 male, 34 female) who presented to our hospital with acute non-variceal upper gastrointestinal bleeding between October 2008 and 2010. Characteristics of patients were evaluated in terms of age, gender, admission date, medical history, endoscopy findings. Results: Mean age was 57.4. The frequent causes of bleeding were duodenal ulcer (34.3%), gastric ulcer (27.8%), gastric and duodenal ulcers (2.8%), esophagitis (5.6%), erosive gastritis (2.8%), and others (3.8%) in endoscopic appearances. Mean ages of patients with duodenal ulcer and gastric ulcer were 50.81±20.4 and 63.87±16.7 years (p=0.02). The percentage of patients using non-steroidal anti-inflammatory drug (NSAİD) was 48%. Endoscopic sclerotherapy was made in 10.2% of patients. Comorbid diseases were present in 34.3% of the patients. The percentage of patients in the months of spring (30.6%) and summer (40.7%) was markedly higher than those in other months. Conclusions: Peptic ulcer disease remains the most common cause of non-variceal upper GI bleeding. Duodenal ulcers are more common than gastric ulcers and tend to occur at a younger age in younger people. The use of NSAID is present in about half of patients with non-variceal upper GI bleeding. Gastro-protective co-therapy should be considered in patients with high-risk or long-term use.