Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer

KEMİK SARBAY, Ahu; Yücel, Ahmet Fikret; KEMİK, Özgür; TÜZÜN, İshak Sefa; PURİSA, Sevim

Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer

Ahmet Fikret YÜCEL, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Cerrahi Anabilim Dalı, Rize, Türkiye)

Özgür KEMİK, (Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Cerrahi Anabilim Dalı, Van, Türkiye)

Ahu KEMİK SARBAY, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Sevim PURİSA, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Biyoistatistik Anabilim Dalı, İstanbul, Türkiye)

İshak Sefa TÜZÜN (SB Haseki Eğitim ve Araştırma Hastanesi, 2. Genel Cerrahi Kliniği, İstanbul, Türkiye)

Balkan Medical Journal

2 1

Yıl: 2012 Cilt: 29 Sayı: 2 Sayfa Aralığı: 144 - 147 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer

Öz:

Amaç: Kolorektal kanserli hastalarda, periferik ve mezenterik serum oksidatif stres düzeyleri arasındaki farkları göstermek. Gereç ve Yöntemler: Mayıs 2005-Mart 2010 yılları arasında kolorektal kanser nedeniyle cerrahi uygulanan 150 hasta prospektif olarak incelendi. Periferik ve mezenterik kandaki oksidatif stres parametreleri arasındaki farklar ölçüldü. Klinik, patolojik ve tümör evresine göre ilişkileri araştırıldı. Bulgular: İleri evre (p<0.01), lenf nodu invazyonu (p<0.01) ve venöz invazyonu (p<0.01) olan tümörlerde oksidatif stres parametreleri daha yüksekti. Mezenterik ve periferik kan örneklerindeki oksidatif stres parametreleri arasında farklılıklar gözlendi. Sonuç: Kolorektal kanserli hastalarda mezenterik oksidatif stres markır düzeyleri periferik düzeylere göre yüksekti. Oksidatif stres markırlarının yüksek olması ilerlemiş kanser evresi ile ilişkilidir.

Anahtar Kelime:

Konular: Cerrahi

Kolorektal kanserli hastalarda klinikopatolojik özellikler ile periferik ve mezenterik serum oksidatif stres düzeyleri arasındaki ilişki

Öz:

Objective: To explore the differences existing between the levels of oxidative stress in peripheral and mesenteric serum in patients with colorectal cancer. Material and Methods: One hundred fifty patients with colorectal cancer who underwent surgery between May 2005 and March 2010 were prospectively analyzed. The differences between oxidative stress parameters in their peripheral and mesenteric blood were measured. The associations between peripheral and mesenteric levels and the staging and clinicopathological variables were investigated. Results: Oxidative stress parameters were higher in patients with advanced tumor staging (p<0.01), lymph node invasion (p<0.01), and venous invasion (p<0.01). Differences between oxidative stress parameters in peripheral and mesenteric blood samples were also observed. Conclusions: The mesenteric levels of the oxidative stress markers were higher than the peripheral levels in these colorectal cancer patients. Higher levels of these oxidative stress markers are associated with an advanced state of cancer.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yücel A, KEMİK Ö, KEMİK SARBAY A, PURİSA S, TÜZÜN İ (2012). Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. , 144 - 147.
Chicago	Yücel Ahmet Fikret,KEMİK Özgür,KEMİK SARBAY Ahu,PURİSA Sevim,TÜZÜN İshak Sefa Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. (2012): 144 - 147.
MLA	Yücel Ahmet Fikret,KEMİK Özgür,KEMİK SARBAY Ahu,PURİSA Sevim,TÜZÜN İshak Sefa Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. , 2012, ss.144 - 147.
AMA	Yücel A,KEMİK Ö,KEMİK SARBAY A,PURİSA S,TÜZÜN İ Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. . 2012; 144 - 147.
Vancouver	Yücel A,KEMİK Ö,KEMİK SARBAY A,PURİSA S,TÜZÜN İ Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. . 2012; 144 - 147.
IEEE	Yücel A,KEMİK Ö,KEMİK SARBAY A,PURİSA S,TÜZÜN İ "Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer." , ss.144 - 147, 2012.
ISNAD	Yücel, Ahmet Fikret vd. "Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer". (2012), 144-147.

APA	Yücel A, KEMİK Ö, KEMİK SARBAY A, PURİSA S, TÜZÜN İ (2012). Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. Balkan Medical Journal, 29(2), 144 - 147.
Chicago	Yücel Ahmet Fikret,KEMİK Özgür,KEMİK SARBAY Ahu,PURİSA Sevim,TÜZÜN İshak Sefa Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. Balkan Medical Journal 29, no.2 (2012): 144 - 147.
MLA	Yücel Ahmet Fikret,KEMİK Özgür,KEMİK SARBAY Ahu,PURİSA Sevim,TÜZÜN İshak Sefa Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. Balkan Medical Journal, vol.29, no.2, 2012, ss.144 - 147.
AMA	Yücel A,KEMİK Ö,KEMİK SARBAY A,PURİSA S,TÜZÜN İ Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. Balkan Medical Journal. 2012; 29(2): 144 - 147.
Vancouver	Yücel A,KEMİK Ö,KEMİK SARBAY A,PURİSA S,TÜZÜN İ Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. Balkan Medical Journal. 2012; 29(2): 144 - 147.
IEEE	Yücel A,KEMİK Ö,KEMİK SARBAY A,PURİSA S,TÜZÜN İ "Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer." Balkan Medical Journal, 29, ss.144 - 147, 2012.
ISNAD	Yücel, Ahmet Fikret vd. "Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer". Balkan Medical Journal 29/2 (2012), 144-147.