Yıl: 2012 Cilt: 12 Sayı: 4 Sayfa Aralığı: 313 - 319 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study

Öz:
Amaç: Karotis-femoral nabız dalga hızı (NDH) günümüzde arteriyel katılık ölçümünün altın standart yöntemidir ve kardiyovasküler olayların bağımsız öngördürücüsüdür. Artmış NDH aterosklerozun bir göstergesi olarak kabul edilmektedir. İzole koroner arter ektazisi (KAE) ve karotis-femoral NDH arasındaki ilişki tam olarak ortaya konamamıştır. Bu çalışmanın amacı, bu ilişkiyi araştırmaktır.Yöntemler: Enine-kesitli gözlemsel bu çalışmaya, herhangi bir görünür darlığı olmayan 34 izole KAE’li hasta ve anjiyografik olarak normal koroner arterli 24 kontrol dahil edildi. Karotis-femoral NDH değerlendirmek için aplanasyon tonometrisi kullanıldı. İstatiksel analiz Mann-Whitney U ve Ki-kare testleri ile yapıldı. Parametreler arası ilişkilerin değerlendirilmesi için çoklu lineer regresyon analizi kullanıldı. Bulgular: Her 2 grubun temel klinik ve laboratuvar parametreleri benzerdi. Karotis-femoral NDH, izole KAE hastalarında kontrol grubuna göre anlamlı olarak daha yüksekti (10.5±2.4 ve 9.2 ±1.7 m/sn, p=0.02). Çoklu regresyon analizinde, yaş (beta=0.23, %95 GA= 0.001-0.094, p=0.04), ektatik damar sayısı (beta=0.24, %95 GA= 0.044-1.07, p=0.03) ve sistolik kan basıncı (beta=0.52, %95 GA= 0.028-0.1, p=0.001) karotis-femoral NDH ile bağımsız ilişkili bulundu. Sonuç: Artmış karotis-femoral NDH ve izole KAE arasında bir ilişki vardır. Bu ilişki, yetişkin popülasyonda, herhangi bir stenozun olmadığı izole koroner arter ektazisinin patogenezinde aterosklerozun etkisi olduğunu göstermektedir.
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

İzole koroner arter ektazili hastalarda karotis-femoral nabız-dalga hızı: Gözlemsel bir çalışma

Öz:
Objective: Carotid-femoral pulse wave velocity (PWV), the current “gold-standard” measure of arterial stiffness, has emerged as an important independent predictor of cardiovascular events. The increased PWV is recognized as an indicator of atherosclerosis. The relationship between isolated coronary artery ectasia (CAE) and carotid-femoral PWV has not been well-described. The aim of our study was to assess this relation. Methods: Thirty-four patients with isolated CAE without any visible coronary stenosis and 24 control subjects with angiographically normal coronary arteries were enrolled to this cross-sectional observational study. Applanation tonometry was applied to assess the carotid-femoral PWV. Statistical analyses were performed by Mann-Whitney U and Chi-square tests. Multiple linear regression analysis was used for the evaluation of the relations of parameters. Results: The baseline clinical and laboratory parameters of the both groups were similar. Patients with isolated CAE had significantly higher carotid-femoral PWV compared to control subjects (10.5±2.4 vs 9.2±1.7 m/s, p=0.02). In multiple regression analysis, age (beta=0.23, 95% CI=0.001- 0.094, p=0.04), number of ectatic vessels (beta=0.24, 95% CI=0.044-1.07, p=0.03), and systolic blood pressure (beta=0.52, 95% CI=0.028-0.1, p=0.001) were found independently related to PWV. Conclusion: We have shown an association between increased carotid-femoral PWV and isolated CAE, suggesting that atherosclerosis may be involved in the pathogenesis of isolated CAE without any coronary stenosis in the adult population.
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, et al. Aneurysmal coronary artery disease. Circulation 1983; 67: 134-8. [CrossRef]
  • 2. Al-Harthi SS, Nouh MS, Arafa M, Al-Nozha M. Aneurysmal dilatation of the coronary arteries: diagnostic patterns and clinical significance. Int J Cardiol 1991; 30: 191-4. [CrossRef]
  • 3. Aksu T, Uygur B, Durukan Koşar M, Güray U, Arat N, Korkmaz S, et al. Coronary artery ectasia: its frequency and relationship with atherosclerotic risk factors in patients undergoing cardiac catheterization. Anadolu Kardiyol Derg 2011; 11: 280-4.
  • 4. Sultana R, Sultana N, Ishaq M, Samad A. The prevalence and clinical profile of angiographic coronary ectasia. J Pak Med Assoc 2011; 61: 372-5.
  • 5. Demopoulos VP, Olympios C, Fakiolas CN, Pissimissis EG, Economides NM, Adamopoulou E, et al. The natural history of aneurysmal coronary artery disease. Heart 1997; 78: 136-41.
  • 6. Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002; 39: 10-5. [CrossRef]
  • 7. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 2002; 106: 2085-90. [CrossRef]
  • 8. Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness on survival in end-stage renal disease. Circulation 1999; 99: 2434-9.
  • 9. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27: 2588-605. [CrossRef]
  • 10. van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, et al. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 2001; 32: 454-60. [CrossRef]
  • 11. Koşar F, Sincer I, Aksoy Y, Topal E, Çehreli S. Increased aortic stiffness in patients with coronary artery ectasia. Coron Artery Dis 2005; 16: 499-04. [CrossRef]
  • 12. Tüzün N, Tanrıverdi H, Evrengül H, Kuru DS, Ergene AO. Aortic elastic properties in patients with coronary artery ectasia. Circ J 2007; 71: 506-10. [CrossRef]
  • 13. Mosti G, Iabichella ML, Picerni P. Pulse wave velocity. A new calculation method. Minerva Cardioangiol 2000; 48: 53-9.
  • 14. Antoniadis AP, Chatzizisis YS, Giannoglou GD. Pathogenetic mechanisms of coronary ectasia. Int J Cardiol 2008; 130: 335-43. [CrossRef]
  • 15. Valente S, Lazzeri C, Giglioli C, Sani F, Romano SM, Margheri M, et al. Clinical expression of coronary artery ectasia. J Cardiovasc Med (Hagerstown) 2007; 8: 815-20. [CrossRef]
  • 16. Chaithiraphan S, Goldberg E, O’Reilly M, Jootar P. Multiple aneurysms of coronary artery in sclerodermal heart disease. Angiology 1973; 24: 86-93. [CrossRef]
  • 17. Tang PH, Segal AJ. Polyarteritis nodosa of infancy. Fatal late complication. JAMA 1971; 217: 1666-70. [CrossRef]
  • 18. McKusick VA. Cardiovascular aspects of Marfan’s syndrome: heritable disorder of connective tissue. Circulation 1955; 11: 321-42.
  • 19. Befeler B, Aranda MJ, Embi A, Mullin FL, El-Sherif N, Lazzara R. Coronary artery aneurysms: study of the etiology, clinical course and effect on left ventricular function and prognosis. Am J Med 1977; 62: 597-607. [CrossRef]
  • 20. Kocaman SA, Taçoy G, Şahinarslan A, Çengel A. Relationship between total and differential leukocyte counts and isolated coronary artery ectasia. Coron Artery Dis 2008; 19: 307-10. [CrossRef]
  • 21. Doğan A, Tüzün N, Türker Y, Akçay S, Kaya S, Özaydın M. Matrix metalloproteinases and inflammatory markers in coronary artery ectasia: their relationship to severity of coronary artery ectasia. Coron Artery Dis 2008; 19: 559-63. [CrossRef]
  • 22. Şen N, Özcan F, Uygur B, Aksu T, Akpınar I, Çay S, et al. Elevated serum uric acid levels in patients with isolated coronary artery ectasia. Türk Kardiyol Dern Arş 2009; 37: 467-72.
  • 23. Dağlı N, Öztürk U, Karaca I, Yavuzkır M, Koca S, Akbulut H, et al. Adiponectin levels in coronary artery ectasia. Heart Vessels 2009; 24: 84-9. [CrossRef]
  • 24. Korkmaz L, Erkuş E, Kırış A, Ağaç MT, Acar Z, Turan T, et al. Lipoprotein phospholipase A2 in patients with isolated coronary artery ectasia. Clin Res Cardiol 2011; 100: 511-4. [CrossRef]
  • 25. Sincer I, Aktürk E, Açıkgöz N, Ermiş N, Koşar MF. Evaluation of the relationship between serum high sensitive C-reactive protein and the elasticity properties of the aorta in patients with coronary artery ectasia. Anadolu Kardiyol Derg 2011; 11: 414-20.
  • 26. Çiçek Y, Durakoğlugil ME, Erdoğan T, Yılmaz A, Uydu HA, Sağlam H, et al. Increased plasminogen activator inhibitor-1 levels in patients with isolated coronary artery ectasia. J Thromb Thrombolysis 2011; 33: 120-3.
  • 27. Giannattasio C, Failla M, Stella ML, Mangoni AA, Turrini D, Carugo S. Angiotensin-converting enzyme inhibition and radial artery compliance in patients with congestive heart failure. Hypertension 1995; 26: 491-6.
  • 28. Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003; 34: 1203-6. [CrossRef]
  • 29. Ferreira I, Henry RM, Twisk JW, van Mechelen W, Kemper HC, Stehouwer CD. The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: the Amsterdam Growth and Health Longitudinal Study. Arch Intern Med 2005; 165: 875-82. [CrossRef]
  • 30. Kool MJ, Hoeks AP, Struijker-Boudier HA, Reneman RS, Van Bortel LM. Short- and long-term effects of smoking on arterial wall properties in habitual smokers. J Am Coll Cardiol 1993; 22: 1881-6. [CrossRef]
  • 31. Wilkinson IB, Prasad K, Hall IR, Thomas A, MacCallum H, Webb DJ, et al. Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol 2002; 39: 1005-11. [CrossRef]
  • 32. Schram MT, Henry RM, van Dijk RA, Kostense PJ, Dekker JM, Nijpels G, et al. Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study. Hypertension 2004; 43: 176-81. [CrossRef]
  • 33. Schram MT, Schalwijk CG, Bootsma AH, Fuller JH, Chaturvedi N, Stehouwer CD. Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. Hypertension 2005; 46: 232-7. [CrossRef]
  • 34. Oliver JJ, Webb DJ. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol 2003; 23: 554-66. [CrossRef]
  • 35. van Bussel BC, Schouten F, Henry RM, Schalkwijk CG, de Boer MR, Ferreira I, et al. Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period. Hypertension 2011; 58: 588-95. [CrossRef]
  • 36. Duprez DA, Somasundaram PE, Sigurdsson G, Hoke L, Florea N, Cohn JN. Relationship between C-reactive protein and arterial stiffness in an asymptomatic population. J Hum Hypertens 2005; 19: 515-9. [CrossRef]
  • 37. Çelik T, Yüksel UC, Demirkol S, Bugan B, İyisoy A, Kabul HK, et al. Relationship between increased systemic inflammation and impaired aortic elasticity in young patients with prehypertension. Blood Press Monit 2011; 16: 55-61. [CrossRef]
  • 38. Nishiwaki Y, Takebayashi T, Omae K, Ishizuka C, Nomiyama T, Sakurai H. Relationship between the blood coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population. J Epidemiol 2000; 10: 34-41. [CrossRef]
  • 39. Van Popele NM, Westendorp IC, Bots ML, Reneman RS, Hoeks AP, Hofman A, et al. Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy nondiabetic middle-aged women. Diabetologia 2000; 43: 665-72. [CrossRef]
  • 40. Gedikli O, Öztürk S, Yılmaz H, Baykan M, Kırış A, Durmuş I, et al. Low total antioxidative capacity levels are associated with augmentation index but not pulse-wave velocity. Heart Vessels 2009; 24: 366-70. [CrossRef]
APA KIRIŞ A, BOSTAN M, KORKMAZ L, AĞAÇ M, ACAR Z, KAPLAN Ş, ÇELİK Ş (2012). Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. , 313 - 319.
Chicago KIRIŞ ABDULKADİR,BOSTAN Mehmet,KORKMAZ Levent,AĞAÇ Mustafa Tarık,ACAR Zeydin,KAPLAN Şahin,ÇELİK Şükrü Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. (2012): 313 - 319.
MLA KIRIŞ ABDULKADİR,BOSTAN Mehmet,KORKMAZ Levent,AĞAÇ Mustafa Tarık,ACAR Zeydin,KAPLAN Şahin,ÇELİK Şükrü Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. , 2012, ss.313 - 319.
AMA KIRIŞ A,BOSTAN M,KORKMAZ L,AĞAÇ M,ACAR Z,KAPLAN Ş,ÇELİK Ş Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. . 2012; 313 - 319.
Vancouver KIRIŞ A,BOSTAN M,KORKMAZ L,AĞAÇ M,ACAR Z,KAPLAN Ş,ÇELİK Ş Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. . 2012; 313 - 319.
IEEE KIRIŞ A,BOSTAN M,KORKMAZ L,AĞAÇ M,ACAR Z,KAPLAN Ş,ÇELİK Ş "Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study." , ss.313 - 319, 2012.
ISNAD KIRIŞ, ABDULKADİR vd. "Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study". (2012), 313-319.
APA KIRIŞ A, BOSTAN M, KORKMAZ L, AĞAÇ M, ACAR Z, KAPLAN Ş, ÇELİK Ş (2012). Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi, 12(4), 313 - 319.
Chicago KIRIŞ ABDULKADİR,BOSTAN Mehmet,KORKMAZ Levent,AĞAÇ Mustafa Tarık,ACAR Zeydin,KAPLAN Şahin,ÇELİK Şükrü Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi 12, no.4 (2012): 313 - 319.
MLA KIRIŞ ABDULKADİR,BOSTAN Mehmet,KORKMAZ Levent,AĞAÇ Mustafa Tarık,ACAR Zeydin,KAPLAN Şahin,ÇELİK Şükrü Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi, vol.12, no.4, 2012, ss.313 - 319.
AMA KIRIŞ A,BOSTAN M,KORKMAZ L,AĞAÇ M,ACAR Z,KAPLAN Ş,ÇELİK Ş Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi. 2012; 12(4): 313 - 319.
Vancouver KIRIŞ A,BOSTAN M,KORKMAZ L,AĞAÇ M,ACAR Z,KAPLAN Ş,ÇELİK Ş Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi. 2012; 12(4): 313 - 319.
IEEE KIRIŞ A,BOSTAN M,KORKMAZ L,AĞAÇ M,ACAR Z,KAPLAN Ş,ÇELİK Ş "Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study." Anadolu Kardiyoloji Dergisi, 12, ss.313 - 319, 2012.
ISNAD KIRIŞ, ABDULKADİR vd. "Carotid-femoral pulse wave velocity in patients with isolated coronary artery ectasia: an observational study". Anadolu Kardiyoloji Dergisi 12/4 (2012), 313-319.