Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

BAYRAK KÖMÜRCÜ, Evrim; Gulec, Cagri; Onat, Altan; ÜNALTUNA, Nihan Erginel; CAN, Günay; coban, neslihan

Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

Neslihan ÇOBAN, (İstanbul Üniversitesi, Deneysel Tıp Araştırma Enstitüsü, Genetik Anabilim Dalı, İstanbul, Türkiye)

Altan ONAT, (İstanbul Üniversitesi, Kardiyoloji Enstitüsü, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Evrim BAYRAK KÖMÜRCÜ, (İstanbul Üniversitesi, Deneysel Tıp Araştırma Enstitüsü, Genetik Anabilim Dalı, İstanbul, Türkiye)

Çağrı GÜLEÇ, (İstanbul Üniversitesi, Deneysel Tıp Araştırma Enstitüsü, Genetik Anabilim Dalı, İstanbul, Türkiye)

Günay CAN, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, İstanbul, Türkiye)

Nihan Erginel ÜNALTUNA (İstanbul Üniversitesi, Deneysel Tıp Araştırma Enstitüsü, Genetik Anabilim Dalı, İstanbul, Türkiye)

Anadolu Kardiyoloji Dergisi

3 1

Yıl: 2014 Cilt: 14 Sayı: 1 Sayfa Aralığı: 18 - 25 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

Öz:

Objective: ATP binding cassette transporter A1 (ABCA1) controls the reverse cholesterol transport. Some ABCA1 variants are correlated with serum high-density lipoprotein cholesterol (HDL-C) and other lipid concentrations. We aimed to explore the relationship of ABCA1 gene with both the lipid profile and coronary heart disease (CHD) risk. Methods: Selected 627 individuals of the Turkish Adult Risk Factor Study were genotyped for ABCA1 R219K polymorphism using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method. Student's t-test, one-way ANOVA, Chi-square test, linear and logistic regression was used for statistical analysis. Results: We demonstrated a gender-specific effect of the R219K polymorphism on plasma lipids and CHD. In men, while homozygosity of the K allele was associated with increased plasma low-density lipoprotein cholesterol (LDL-C) (p<0.05) and total cholesterol concentrations (p<0.05), carriage of this allele was associated with higher HDL-C concentrations (p<0.05) after adjustment for associated risk factors, but not with CHD. In women, however, without being related to HDL-C levels, each 219K allele was associated with 10% higher triglycerides (TG) concentrations (p<0.05). R219K heterozygosity in women independently doubled (95% CI 1.00; 3.80) the odds ratio for CHD risk in regression models, after adjust- ment for several variables. Interaction of TG elevation (>140 mg/dL) with CHD was demonstrated in female 219RK genotype carriers. Conclusion: R219 allele of the ABCA1 gene independently confers CHD risk in heterozygote Turkish women, not via reduced HDL-C, but interact- ing with elevated TG expressed by the 219K allele, but not in men.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	coban n, Onat A, BAYRAK KÖMÜRCÜ E, Gulec C, CAN G, ÜNALTUNA N (2014). Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. , 18 - 25.
Chicago	coban neslihan,Onat Altan,BAYRAK KÖMÜRCÜ Evrim,Gulec Cagri,CAN Günay,ÜNALTUNA Nihan Erginel Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. (2014): 18 - 25.
MLA	coban neslihan,Onat Altan,BAYRAK KÖMÜRCÜ Evrim,Gulec Cagri,CAN Günay,ÜNALTUNA Nihan Erginel Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. , 2014, ss.18 - 25.
AMA	coban n,Onat A,BAYRAK KÖMÜRCÜ E,Gulec C,CAN G,ÜNALTUNA N Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. . 2014; 18 - 25.
Vancouver	coban n,Onat A,BAYRAK KÖMÜRCÜ E,Gulec C,CAN G,ÜNALTUNA N Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. . 2014; 18 - 25.
IEEE	coban n,Onat A,BAYRAK KÖMÜRCÜ E,Gulec C,CAN G,ÜNALTUNA N "Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults." , ss.18 - 25, 2014.
ISNAD	coban, neslihan vd. "Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults". (2014), 18-25.

APA	coban n, Onat A, BAYRAK KÖMÜRCÜ E, Gulec C, CAN G, ÜNALTUNA N (2014). Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. Anadolu Kardiyoloji Dergisi, 14(1), 18 - 25.
Chicago	coban neslihan,Onat Altan,BAYRAK KÖMÜRCÜ Evrim,Gulec Cagri,CAN Günay,ÜNALTUNA Nihan Erginel Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. Anadolu Kardiyoloji Dergisi 14, no.1 (2014): 18 - 25.
MLA	coban neslihan,Onat Altan,BAYRAK KÖMÜRCÜ Evrim,Gulec Cagri,CAN Günay,ÜNALTUNA Nihan Erginel Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. Anadolu Kardiyoloji Dergisi, vol.14, no.1, 2014, ss.18 - 25.
AMA	coban n,Onat A,BAYRAK KÖMÜRCÜ E,Gulec C,CAN G,ÜNALTUNA N Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. Anadolu Kardiyoloji Dergisi. 2014; 14(1): 18 - 25.
Vancouver	coban n,Onat A,BAYRAK KÖMÜRCÜ E,Gulec C,CAN G,ÜNALTUNA N Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults. Anadolu Kardiyoloji Dergisi. 2014; 14(1): 18 - 25.
IEEE	coban n,Onat A,BAYRAK KÖMÜRCÜ E,Gulec C,CAN G,ÜNALTUNA N "Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults." Anadolu Kardiyoloji Dergisi, 14, ss.18 - 25, 2014.
ISNAD	coban, neslihan vd. "Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults". Anadolu Kardiyoloji Dergisi 14/1 (2014), 18-25.