Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta

AÇIKSARI, Gönül; Çiftçi, Serkan; Demir, Bulent; Demir, Esra; ÜNGAN, İsmail; KARAKAYA, Osman; Özyazgan, Sibel; ÇAĞLAR, İlker Murat; TÜRELİ OKTAY, Hande; ÖZDE, CEM

Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta

Bülent DEMİR, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

İlker Murat ÇAĞLAR, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Hande TÜRELİ OKTAY, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Cem ÖZDE, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Gönül AÇIKSARI, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Serkan ÇİFTÇİ, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

İsmail ÜNGAN, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Esra DEMİR, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, İç Hastalıkları Kliniği, İstanbul, Türkiye)

Osman KARAKAYA, (Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İstanbul, Türkiye)

Sibel ÖZYAZGAN (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Medikal Farmakoloji Anabilim Dalı, İstanbul, Türkiye)

Anadolu Kardiyoloji Dergisi

2 1

Yıl: 2014 Cilt: 14 Sayı: 2 Sayfa Aralığı: 106 - 114 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta

Öz:

Objective: This study aimed to evaluate the serum gamma-glutamyltransferase (GGT) levels as an indirect marker of elevated oxidative stress in patients with dilated ascending aorta. Methods: The study was designed as an observational cross-sectional controlled study. One hundred consecutive patients with dilated ascending aorta and 50 consecutive controls with normal ascending aorta diameter were selected for the study by comprehensive transtho- racic echocardiography (TTE). The aortic dilatation group was divided into two subgroups, according to the literature as the ectasia group (3.8-4.3 cm, 53 patients, 24 male and 29 female, mean age: 62.9±10.9 years) and the aneurysm group (≥4.4 cm, 47 patients, 18 male and 29 female, mean age: 65.5±11.1 years). The control group consisted of patients demonstrating no ascending aorta dilatation (≤3.7 cm, 50 patients, 24 male and 26 female, mean age: 62.7±9.2 years). ANOVA, Mann-Whitney U test, Pearson’s correlation analysis, multivariate logistic regression analy- sis, and receiver-operator curve analysis were used for statistical analysis. Results: Regarding the comparison of laboratory parameters between the patient and control groups, serum gamma-glutamyltransferase (GGT) levels were found to be statistically significantly higher in both of the aortic dilatation subgroups than in the control group (p<0.001). In the cor- relation analysis between the ascending aorta diameter and GGT, a statistically significant positive correlation was found (r=0.282, p<0.001). The multivariate regression analysis revealed a significant relationship between GGT and the proximal ascending aorta diameter (β=0.131, odds ratio: 1.140, 95% CI: 1.060-1.225, p<0.001). Conclusion: GGT as a marker of oxidative stress may play a role in the pathogenesis of aneurysm of the ascending aorta. (Anadolu Kardiyol Derg 2014; 14: 106-14)

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Demir B, ÇAĞLAR İ, TÜRELİ OKTAY H, ÖZDE C, AÇIKSARI G, Çiftçi S, ÜNGAN İ, Demir E, KARAKAYA O, Özyazgan S (2014). Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. , 106 - 114.
Chicago	Demir Bulent,ÇAĞLAR İlker Murat,TÜRELİ OKTAY Hande,ÖZDE CEM,AÇIKSARI Gönül,Çiftçi Serkan,ÜNGAN İsmail,Demir Esra,KARAKAYA Osman,Özyazgan Sibel Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. (2014): 106 - 114.
MLA	Demir Bulent,ÇAĞLAR İlker Murat,TÜRELİ OKTAY Hande,ÖZDE CEM,AÇIKSARI Gönül,Çiftçi Serkan,ÜNGAN İsmail,Demir Esra,KARAKAYA Osman,Özyazgan Sibel Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. , 2014, ss.106 - 114.
AMA	Demir B,ÇAĞLAR İ,TÜRELİ OKTAY H,ÖZDE C,AÇIKSARI G,Çiftçi S,ÜNGAN İ,Demir E,KARAKAYA O,Özyazgan S Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. . 2014; 106 - 114.
Vancouver	Demir B,ÇAĞLAR İ,TÜRELİ OKTAY H,ÖZDE C,AÇIKSARI G,Çiftçi S,ÜNGAN İ,Demir E,KARAKAYA O,Özyazgan S Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. . 2014; 106 - 114.
IEEE	Demir B,ÇAĞLAR İ,TÜRELİ OKTAY H,ÖZDE C,AÇIKSARI G,Çiftçi S,ÜNGAN İ,Demir E,KARAKAYA O,Özyazgan S "Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta." , ss.106 - 114, 2014.
ISNAD	Demir, Bulent vd. "Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta". (2014), 106-114.

APA	Demir B, ÇAĞLAR İ, TÜRELİ OKTAY H, ÖZDE C, AÇIKSARI G, Çiftçi S, ÜNGAN İ, Demir E, KARAKAYA O, Özyazgan S (2014). Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. Anadolu Kardiyoloji Dergisi, 14(2), 106 - 114.
Chicago	Demir Bulent,ÇAĞLAR İlker Murat,TÜRELİ OKTAY Hande,ÖZDE CEM,AÇIKSARI Gönül,Çiftçi Serkan,ÜNGAN İsmail,Demir Esra,KARAKAYA Osman,Özyazgan Sibel Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. Anadolu Kardiyoloji Dergisi 14, no.2 (2014): 106 - 114.
MLA	Demir Bulent,ÇAĞLAR İlker Murat,TÜRELİ OKTAY Hande,ÖZDE CEM,AÇIKSARI Gönül,Çiftçi Serkan,ÜNGAN İsmail,Demir Esra,KARAKAYA Osman,Özyazgan Sibel Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. Anadolu Kardiyoloji Dergisi, vol.14, no.2, 2014, ss.106 - 114.
AMA	Demir B,ÇAĞLAR İ,TÜRELİ OKTAY H,ÖZDE C,AÇIKSARI G,Çiftçi S,ÜNGAN İ,Demir E,KARAKAYA O,Özyazgan S Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. Anadolu Kardiyoloji Dergisi. 2014; 14(2): 106 - 114.
Vancouver	Demir B,ÇAĞLAR İ,TÜRELİ OKTAY H,ÖZDE C,AÇIKSARI G,Çiftçi S,ÜNGAN İ,Demir E,KARAKAYA O,Özyazgan S Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta. Anadolu Kardiyoloji Dergisi. 2014; 14(2): 106 - 114.
IEEE	Demir B,ÇAĞLAR İ,TÜRELİ OKTAY H,ÖZDE C,AÇIKSARI G,Çiftçi S,ÜNGAN İ,Demir E,KARAKAYA O,Özyazgan S "Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta." Anadolu Kardiyoloji Dergisi, 14, ss.106 - 114, 2014.
ISNAD	Demir, Bulent vd. "Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta". Anadolu Kardiyoloji Dergisi 14/2 (2014), 106-114.