Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study

BİLEN, Emine; Kurt, Mustafa; BÜYÜKKAYA, Eyüp; KARAKAŞ, Mehmet Fatih; ŞEN, Nihat; AKÇAY, Adnan Burak; TANBOĞA, İbrahim Halil

Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study

Mustafa KURT, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Hatay, Türkiye)

İbrahim Halil TANBOĞA, (Atatürk Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Erzurum, Türkiye)

Eyüp BÜYÜKKAYA, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Hatay, Türkiye)

Mehmet Fatih KARAKAŞ, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Hatay, Türkiye)

Adnan Burak AKÇAY, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Hatay, Türkiye)

Nihat ŞEN, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Hatay, Türkiye)

Emine BİLEN (Atatürk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Anadolu Kardiyoloji Dergisi

0 1

Yıl: 2014 Cilt: 14 Sayı: 2 Sayfa Aralığı: 128 - 133 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study

Öz:

Objective: We aimed to investigate left atrium (LA) function by speckle tracking echocardiography in patients with metabolic syndrome (MetSyn) and to show a possible relationship between the severity of MetSyn and LA function and to determine the predictors of low strain in MetSyn patients. Methods: Our study design was observational and cross-sectional design consisted of 80 MetSyn patients without overt diabetes and 50 con- trols. The patients were classified into three groups based on the number of MetSyn criteria. The peak LA strain at the end of the ventricular systole (LAs-strain) as well as the LA strain with LA contraction (LAa-strain) was obtained. Correlation analysis performed to assess the asso- ciation of LA strain parameters with the severity of MetSyn and logistic regression analysis performed to assess the relationship of low LA strain with MetSyn. Results: Both LAs (37.5±8.7 vs. 26.0±10.2, p<0.001) and LAa (19.9±6.3 vs. 13.0±6.4, p<0.001) strain measurements were found to be significantly decreased in patients with MetSyn when compared to the control group. Moreover, both LAs and LAa were found to be significantly decreased with the increasing severity of the MetSyn. A multiple logistic regression analysis demonstrated that the presence of MetSyn [OR:0.26 (95% CI 0.06-0.89), p=0.032] and left ventricular ejection fraction [OR:1.14 (95% CI 1.03-1.27), p=0.021] were independent predictors of LAs strain. Conclusion: MetSyn is associated with reduced LAs strain and LAa strain representing LA reservoir and pump function, respectively. Furthermore, LA mechanical function decreases even more with the increasing severity of the MetSyn. (Anadolu Kardiyol Derg 2014; 14: 128-33)

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Chamberlain AM, Agarwal SK, Ambrose M, Folsom AR, Soliman EZ, Alonso A. Metabolic syndrome and incidence of atrial fibrillation among blacks and whites in the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2010; 159: 850-6. [CrossRef] 2. Watanabe H, Tanabe N, Watanabe T, Darbar D, Roden DM, Sasaki S, et al. Metabolic syndrome and risk of development of atrial fibrillation: the Niigata preventive medicine study. Circulation 2008; 117: 1255-60. [CrossRef] Nicolaou VN, Papadakis JE, Karatzis EN, Dermitzaki SI, Tsakiris AK, Skoufas PD. Impact of the metabolic syndrome on atrial size in patients with new-onset atrial fibrillation. Angiology 2007; 58: 21-5. [CrossRef] Kim DG, Lee KJ, Lee S, Jeong SY, Lee YS, Choi YJ, et al. Feasibility of two-dimensional global longitudinal strain and strain rate imaging for the assessment of left atrial function: a study in subjects with a low probability of cardiovascular disease and normal exercise capacity. Echocardiography 2009; 26: 1179-87. [CrossRef] D'Andrea A, Caso P Romano S, Scarafile R, Riegler L, Salerno G, et , al. Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study. Eur Heart J 2007; 28: 2738-48. [CrossRef] Shih JY, Tsai WC, Huang YY, Liu YW, Lin CC, Huang YS, et al. Association of decreased left atrial strain and strain rate with stroke in chronic atrial fibrillation. J Am Soc Echocardiogr 2011; 24: 513-9. [CrossRef] Tsai WC, Lee CH, Lin CC, Liu YW, Huang YY, Li WT, et al. Association of left atrial strain and strain rate assessed by speckle tracking echocardiography with paroxysmal atrial fibrillation. Echocardiography 2009; 26: 1188-94. [CrossRef] Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification. Eur J Echocardiogr 2006; 7: 79-108. [CrossRef] International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. http://www.idf.org/webdata/ docs/IDF_Meta_def_final.pdf. 10. Tsai WC, Liu YW, Huang YY, Tsai LM, Lin LJ. Decreased mechanical function of left atrium assessed by speckle tracking and tissue Doppler echocardiography in patients with congestive heart failure. J Med Ultrasound 2012; 20: 32-42. [CrossRef] 11. Mor-Avi V, Lang RM, Badano LP Belohlavek M, Cardim NM, , Derumeaux G, et al. Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. Eur J Echocardiogr 2011; 12: 167-205. [CrossRef] 12. Zhang X, Zhang S, Li Y, Detrano RC, Chen K, Li X, et al. Association of obesity and atrial fibrillation among middle-aged and elderly Chinese. Int J Obes (Lond) 2009; 33: 1318-25. [CrossRef] 13. Tanner RM, Baber U, Carson AP Voeks J, Brown TM, Soliman EZ, et al. , Association of the metabolic syndrome with atrial fibrillation among United States adults [from the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study]. Am J Cardiol 2011; 108: 227-32. [CrossRef] 14. Young ME, McNulty P Taegtmeyer H. Adaptation and maladaptation , of the heart in diabetes: Part II: potential mechanisms. Circulation 2002; 105: 1861-70. [CrossRef] 15. Chang SL, Tuan TC, Tai CT, Lin YJ, Lo LW, Hu YF et al. Comparison of , outcome in catheter ablation of atrial fibrillation in patients with versus without the metabolic syndrome. Am J Cardiol 2009; 103: 67-72. [CrossRef] 16. Gutman J, Wang YS, Wahr D, Schiller NB. Normal left atrial function determined by 2-dimensional echocardiography. Am J Cardiol 1983; 51: 336-40. [CrossRef] 17. Kurt M, Wang J, Torre-Amione G, Nagueh SF. Left atrial function in diastolic heart failure. Circ Cardiovasc Imaging 2009; 2: 10-5. [CrossRef] 18. Rosca M, Lancellotti P Popescu BA, Piérard LA. Left atrial function: , pathophysiology, echocardiographic assessment, and clinical applications. Heart 2011; 97: 1982-9. [CrossRef] 19. Todaro MC, Choudhuri I, Belohlavek M, Jahangir A, Carerj S, Oreto L, et al. New echocardiographic techniques for evaluation of left atrial mechanics. Eur Heart J Cardiovasc Imaging 2012; 13: 973-84. [CrossRef] 20. Cameli M, Lisi M, Mondillo S, Padeletti M, Ballo P Tsioulpas C, et , al. Left atrial longitudinal strain by speckle tracking echocardiography correlates well with left ventricular filling pressures in patients with heart failure. Cardiovasc Ultrasound 2010; 8: 14. [CrossRef] 21. Eshoo S, Boyd AC, Ross DL, Marwick TH, Thomas L. Strain rate evaluation of phasic atrial function in hypertension. Heart 2009; 95: 1184-91. 22. Kurt M, Tanboğa IH, Aksakal E, Kaya A, Işık T, Ekinci M, et al. Relation of left ventricular end-diastolic pressure and N-terminal pro-brain natriuretic peptide level with left atrial deformation parameters. Eur Heart J Cardiovasc Imaging 2012; 13: 524-30. [CrossRef]

APA	Kurt M, TANBOĞA İ, BÜYÜKKAYA E, KARAKAŞ M, AKÇAY A, ŞEN N, BİLEN E (2014). Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. , 128 - 133.
Chicago	Kurt Mustafa,TANBOĞA İbrahim Halil,BÜYÜKKAYA Eyüp,KARAKAŞ Mehmet Fatih,AKÇAY Adnan Burak,ŞEN Nihat,BİLEN Emine Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. (2014): 128 - 133.
MLA	Kurt Mustafa,TANBOĞA İbrahim Halil,BÜYÜKKAYA Eyüp,KARAKAŞ Mehmet Fatih,AKÇAY Adnan Burak,ŞEN Nihat,BİLEN Emine Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. , 2014, ss.128 - 133.
AMA	Kurt M,TANBOĞA İ,BÜYÜKKAYA E,KARAKAŞ M,AKÇAY A,ŞEN N,BİLEN E Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. . 2014; 128 - 133.
Vancouver	Kurt M,TANBOĞA İ,BÜYÜKKAYA E,KARAKAŞ M,AKÇAY A,ŞEN N,BİLEN E Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. . 2014; 128 - 133.
IEEE	Kurt M,TANBOĞA İ,BÜYÜKKAYA E,KARAKAŞ M,AKÇAY A,ŞEN N,BİLEN E "Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study." , ss.128 - 133, 2014.
ISNAD	Kurt, Mustafa vd. "Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study". (2014), 128-133.

APA	Kurt M, TANBOĞA İ, BÜYÜKKAYA E, KARAKAŞ M, AKÇAY A, ŞEN N, BİLEN E (2014). Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. Anadolu Kardiyoloji Dergisi, 14(2), 128 - 133.
Chicago	Kurt Mustafa,TANBOĞA İbrahim Halil,BÜYÜKKAYA Eyüp,KARAKAŞ Mehmet Fatih,AKÇAY Adnan Burak,ŞEN Nihat,BİLEN Emine Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. Anadolu Kardiyoloji Dergisi 14, no.2 (2014): 128 - 133.
MLA	Kurt Mustafa,TANBOĞA İbrahim Halil,BÜYÜKKAYA Eyüp,KARAKAŞ Mehmet Fatih,AKÇAY Adnan Burak,ŞEN Nihat,BİLEN Emine Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. Anadolu Kardiyoloji Dergisi, vol.14, no.2, 2014, ss.128 - 133.
AMA	Kurt M,TANBOĞA İ,BÜYÜKKAYA E,KARAKAŞ M,AKÇAY A,ŞEN N,BİLEN E Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. Anadolu Kardiyoloji Dergisi. 2014; 14(2): 128 - 133.
Vancouver	Kurt M,TANBOĞA İ,BÜYÜKKAYA E,KARAKAŞ M,AKÇAY A,ŞEN N,BİLEN E Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. Anadolu Kardiyoloji Dergisi. 2014; 14(2): 128 - 133.
IEEE	Kurt M,TANBOĞA İ,BÜYÜKKAYA E,KARAKAŞ M,AKÇAY A,ŞEN N,BİLEN E "Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study." Anadolu Kardiyoloji Dergisi, 14, ss.128 - 133, 2014.
ISNAD	Kurt, Mustafa vd. "Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study". Anadolu Kardiyoloji Dergisi 14/2 (2014), 128-133.