Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome

UZEL, Hazel; BADAK, Özer; Baris, Nezihi; AYTEMİZ, Fatih; GÖLDELİ, Özhan; Ozpelit, Ebru; AKDENİZ, Bahri

Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome

Hazel UZEL, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Ebru ÖZPELİT, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Özer BADAK, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Bahri AKDENİZ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Nezihi BARIŞ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Fatih AYTEMİZ, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Özhan GÖLDELİ (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)

Anadolu Kardiyoloji Dergisi

1 0

Yıl: 2014 Cilt: 14 Sayı: 2 Sayfa Aralığı: 134 - 139 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome

Öz:

Objective: Clopidogrel therapy is the standard of care in patients with acute coronary syndrome (ACS) and stent implantation. However, con- cern arises because 25% of subjects are nonresponders to clopidogrel. As this nonresponsiveness is associated with increased adverse out- come, detection of these subjects in daily practice is important in order to withhold a more aggressive therapy and closer follow up. In this study we aimed to evaluate the relation between mean platelet volume (MPV) which is an indicator of platelet activation and clopidogrel nonrespon- siveness. Methods: The study was planned as a prospective cohort study. A total of 185 patients who had been on clopidogrel therapy for any acute coronary syndrome were enrolled in this study. Clopidogrel responsiveness was analyzed by Multiplate MP-0120 device by using the method of whole blood aggregometry. Blood samples were drawn 3.5 days after clopidogrel loading dose. The amount of ADP induced platelet aggrega- tion was assessed as area under curve (AUC), and a cut-off value of 500, above which the patient is considered as clopidogrel nonresponder, was used. MPV was analyzed from the blood which were sampled at the admission of the patient by using automatic hemocounter. Independent sample t-test, ROC analyses and logistic regression analsis were used in statistical analysis. Results: Among the 185 patients analyzed 41 were found to be clopidogrel nonresponder (22.1%). Mean MPV was found to be significantly higher in nonresponders compared to responders (8.7±0.82 fL vs. 8.1±0.83 fL, p<0.001). A cut-off value of 8.3 fL for MPV was detected in predic- tion of clopidogrel nonresponsiveness with a sensitivity of 76.6% and specificity of 68.3% (OR: 6.4; 95% CI 2.9-14.1, AUC: 0.70, p<0.001). Conclusion: This study showed that MPV can be used as a predictor of clopidogrel resistance in patients with ACS. (Anadolu Kardiyol Derg 2014; 14: 134-9)

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	UZEL H, Ozpelit E, BADAK Ö, AKDENİZ B, Baris N, AYTEMİZ F, GÖLDELİ Ö (2014). Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. , 134 - 139.
Chicago	UZEL Hazel,Ozpelit Ebru,BADAK Özer,AKDENİZ Bahri,Baris Nezihi,AYTEMİZ Fatih,GÖLDELİ Özhan Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. (2014): 134 - 139.
MLA	UZEL Hazel,Ozpelit Ebru,BADAK Özer,AKDENİZ Bahri,Baris Nezihi,AYTEMİZ Fatih,GÖLDELİ Özhan Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. , 2014, ss.134 - 139.
AMA	UZEL H,Ozpelit E,BADAK Ö,AKDENİZ B,Baris N,AYTEMİZ F,GÖLDELİ Ö Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. . 2014; 134 - 139.
Vancouver	UZEL H,Ozpelit E,BADAK Ö,AKDENİZ B,Baris N,AYTEMİZ F,GÖLDELİ Ö Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. . 2014; 134 - 139.
IEEE	UZEL H,Ozpelit E,BADAK Ö,AKDENİZ B,Baris N,AYTEMİZ F,GÖLDELİ Ö "Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome." , ss.134 - 139, 2014.
ISNAD	UZEL, Hazel vd. "Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome". (2014), 134-139.

APA	UZEL H, Ozpelit E, BADAK Ö, AKDENİZ B, Baris N, AYTEMİZ F, GÖLDELİ Ö (2014). Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. Anadolu Kardiyoloji Dergisi, 14(2), 134 - 139.
Chicago	UZEL Hazel,Ozpelit Ebru,BADAK Özer,AKDENİZ Bahri,Baris Nezihi,AYTEMİZ Fatih,GÖLDELİ Özhan Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. Anadolu Kardiyoloji Dergisi 14, no.2 (2014): 134 - 139.
MLA	UZEL Hazel,Ozpelit Ebru,BADAK Özer,AKDENİZ Bahri,Baris Nezihi,AYTEMİZ Fatih,GÖLDELİ Özhan Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. Anadolu Kardiyoloji Dergisi, vol.14, no.2, 2014, ss.134 - 139.
AMA	UZEL H,Ozpelit E,BADAK Ö,AKDENİZ B,Baris N,AYTEMİZ F,GÖLDELİ Ö Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. Anadolu Kardiyoloji Dergisi. 2014; 14(2): 134 - 139.
Vancouver	UZEL H,Ozpelit E,BADAK Ö,AKDENİZ B,Baris N,AYTEMİZ F,GÖLDELİ Ö Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome. Anadolu Kardiyoloji Dergisi. 2014; 14(2): 134 - 139.
IEEE	UZEL H,Ozpelit E,BADAK Ö,AKDENİZ B,Baris N,AYTEMİZ F,GÖLDELİ Ö "Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome." Anadolu Kardiyoloji Dergisi, 14, ss.134 - 139, 2014.
ISNAD	UZEL, Hazel vd. "Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome". Anadolu Kardiyoloji Dergisi 14/2 (2014), 134-139.