The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study

TÜLÜCE YAKAR, Selcen; ARIKAN, Erdinç; köseoğlu, mehmet; YAĞIZ KOCAĞRA, İdil; AKÇAY AYYILDIZ, Filiz; TOKLU, Oğuzhan; BAYATA, Serdar; YEŞİL, Murat; Semerci, Tuna

The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study

Filiz AKÇAY AYYILDIZ, (Anamur Devlet Hastanesi, Kardiyoloji Kliniği, Mersin, Türkiye)

Serdar BAYATA, (Atatürk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Tuna SEMERCİ, (Sandıklı Devlet Hastanesi, Biyokimya Laboratuvarı, Sandıklı, Afyon)

Murat YEŞİL, (Atatürk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Oğuzhan TOKLU, (Tekirdağ Devlet Hastanesi, Kardiyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Erdinç ARIKAN, (Atatürk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Selcen TÜLÜCE YAKAR, (Atatürk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Ankara, Türkiye)

Mehmet KÖSEOĞLU, (İzmir Atatürk Eğitim ve Araştırma Hastanesi, Biyokimya ve Klinik Biyokimya Kliniği, İzmir, Türkiye)

İdil YAĞIZ KOCAĞRA (Ödemiş Devlet Hastanesi, Kardiyoloji Kliniği, İzmir, Türkiye)

Anadolu Kardiyoloji Dergisi

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Yıl: 2014 Cilt: 14 Sayı: 2 Sayfa Aralığı: 156 - 161 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study

Öz:

Objective: To compare intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) serum levels between patients with stable (SAP) and unstable angina pectoris (USAP) undergoing coronary angiography (CAG), investigate effects of CAG on ICAM-1, VCAM-1 levels in SAP USAP patients; probable different effects of non-ionic radiocontrast media (RCM), iso-osmotic iodixanol and low osmolar iopamidol, on , these adhesion molecules (AM). Methods: In this randomized, prospective study, 2 groups consisting of patients with SAP (n=22) and USAP (n=22) undergoing CAG were included. For halves of each group iopamidol, for the other halves iodixanol were used as RCM, in turn for randomization. The patients were divided into 4 subgroups according to clinical presentations and used RCM(SAP-iodixanol, SAP-iopamidol USAP-iodixanol, USAP-iopamidol). ICAM-1, VCAM-1 levels were measured just before and 12 hours after CAG. Repeated measurements were compared with two-way ANOVA test. Results: Baseline VCAM-1 concentration was higher in USAP group than SAP group (p=0.001). ICAM-1, VCAM-1 concentrations increased signifi- cantly following CAG in SAP USAP groups. ICAM-1, VCAM-1 concentration increments; didn’t reach statistical significance in SAP-iodixanol sub- , group, reached a borderline significance in SAP-iopamidol subgroup (p=0.06, p=0.06). In USAP-iodixanol subgroup; only VCAM-1 (p<0.001), in USAP- iopamidol subgroup; ICAM-1 (p=0.009), VCAM-1 (p=0.006) levels increased significantly following CAG. No complication was observed. Conclusion: To our knowledge, this is the first study indicating ICAM-1, VCAM-1 inducing effect of CAG in patients with SAP USAP and differential , effects of iodixanol and iopamidol on ICAM-1, VCAM-1 serum levels. Further studies are needed to clarify the effects of CAG and different RCM on vascular inflammation, vessel injury, serum AM levels and their clinical significance. This study should be taken as a pilot, hypothesis-generating study. (Anadolu Kardiyol Derg 2014; 14: 156-61)

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AKÇAY AYYILDIZ F, BAYATA S, Semerci T, YEŞİL M, TOKLU O, ARIKAN E, TÜLÜCE YAKAR S, köseoğlu m, YAĞIZ KOCAĞRA İ (2014). The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. , 156 - 161.
Chicago	AKÇAY AYYILDIZ Filiz,BAYATA Serdar,Semerci Tuna,YEŞİL Murat,TOKLU Oğuzhan,ARIKAN Erdinç,TÜLÜCE YAKAR Selcen,köseoğlu mehmet,YAĞIZ KOCAĞRA İdil The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. (2014): 156 - 161.
MLA	AKÇAY AYYILDIZ Filiz,BAYATA Serdar,Semerci Tuna,YEŞİL Murat,TOKLU Oğuzhan,ARIKAN Erdinç,TÜLÜCE YAKAR Selcen,köseoğlu mehmet,YAĞIZ KOCAĞRA İdil The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. , 2014, ss.156 - 161.
AMA	AKÇAY AYYILDIZ F,BAYATA S,Semerci T,YEŞİL M,TOKLU O,ARIKAN E,TÜLÜCE YAKAR S,köseoğlu m,YAĞIZ KOCAĞRA İ The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. . 2014; 156 - 161.
Vancouver	AKÇAY AYYILDIZ F,BAYATA S,Semerci T,YEŞİL M,TOKLU O,ARIKAN E,TÜLÜCE YAKAR S,köseoğlu m,YAĞIZ KOCAĞRA İ The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. . 2014; 156 - 161.
IEEE	AKÇAY AYYILDIZ F,BAYATA S,Semerci T,YEŞİL M,TOKLU O,ARIKAN E,TÜLÜCE YAKAR S,köseoğlu m,YAĞIZ KOCAĞRA İ "The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study." , ss.156 - 161, 2014.
ISNAD	AKÇAY AYYILDIZ, Filiz vd. "The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study". (2014), 156-161.

APA	AKÇAY AYYILDIZ F, BAYATA S, Semerci T, YEŞİL M, TOKLU O, ARIKAN E, TÜLÜCE YAKAR S, köseoğlu m, YAĞIZ KOCAĞRA İ (2014). The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. Anadolu Kardiyoloji Dergisi, 14(2), 156 - 161.
Chicago	AKÇAY AYYILDIZ Filiz,BAYATA Serdar,Semerci Tuna,YEŞİL Murat,TOKLU Oğuzhan,ARIKAN Erdinç,TÜLÜCE YAKAR Selcen,köseoğlu mehmet,YAĞIZ KOCAĞRA İdil The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. Anadolu Kardiyoloji Dergisi 14, no.2 (2014): 156 - 161.
MLA	AKÇAY AYYILDIZ Filiz,BAYATA Serdar,Semerci Tuna,YEŞİL Murat,TOKLU Oğuzhan,ARIKAN Erdinç,TÜLÜCE YAKAR Selcen,köseoğlu mehmet,YAĞIZ KOCAĞRA İdil The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. Anadolu Kardiyoloji Dergisi, vol.14, no.2, 2014, ss.156 - 161.
AMA	AKÇAY AYYILDIZ F,BAYATA S,Semerci T,YEŞİL M,TOKLU O,ARIKAN E,TÜLÜCE YAKAR S,köseoğlu m,YAĞIZ KOCAĞRA İ The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. Anadolu Kardiyoloji Dergisi. 2014; 14(2): 156 - 161.
Vancouver	AKÇAY AYYILDIZ F,BAYATA S,Semerci T,YEŞİL M,TOKLU O,ARIKAN E,TÜLÜCE YAKAR S,köseoğlu m,YAĞIZ KOCAĞRA İ The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study. Anadolu Kardiyoloji Dergisi. 2014; 14(2): 156 - 161.
IEEE	AKÇAY AYYILDIZ F,BAYATA S,Semerci T,YEŞİL M,TOKLU O,ARIKAN E,TÜLÜCE YAKAR S,köseoğlu m,YAĞIZ KOCAĞRA İ "The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study." Anadolu Kardiyoloji Dergisi, 14, ss.156 - 161, 2014.
ISNAD	AKÇAY AYYILDIZ, Filiz vd. "The effects of iodixanol and iopamidol on adhesion molecule serum levels in patients with angina pectoris undergoing coronary angiography: a randomized study". Anadolu Kardiyoloji Dergisi 14/2 (2014), 156-161.