Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study

ERDOĞAN, Turan; Durakoglugil, Murtaza Emre; ÇANĞA, Aytun; Ergül, Elif; UĞURLU, Yavuz; KOCAMAN, Sinan Altan; ÇETİN, Mustafa

Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study

Turan ERDOĞAN, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Mustafa ÇETİN, (SB Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Rize, Türkiye)

Sinan Altan KOCAMAN, (SB Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Rize, Türkiye)

Murtaza Emre DURAKOĞLUGİL, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Elif ERGÜL, (SB Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Rize, Türkiye)

Yavuz UĞURLU, (SB Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Rize, Türkiye)

Aytun ÇANĞA (SB Rize Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Rize, Türkiye)

Anadolu Kardiyoloji Dergisi

0 1

Yıl: 2013 Cilt: 13 Sayı: 4 Sayfa Aralığı: 320 - 327 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study

Öz:

Amaç: Epikardiyal adipoz doku (EAD) çeşitli enflamatuvar mediyatörler ve büyüme faktörleri salarak miyokart ve vücut üzerine endokrin ve parakrin etkilere sahiptir. Bu çalışmada hipertansiyonlu (HT) hastalarda EAD ve kardiyovasküler morbidite ve mortalitenin güçlü bir öngörücüsü olan sol ventri- kül hipertrofisi (SVH) arasındaki olası ilişkiyi yaş, kan basıncı ve metabolik parametrelerden bağımsız olarak araştırmayı amaçladık. Yöntemler: Bu çalışma EAD ve SVH ölçümleri yanında tam bir ekokardiyografik değerlendirmesi yapılan 107 ardışık, tedavi almamış esansiyel HT has- tasında yapılan kesitsel ve gözlemsel bir çalışmadır. Kan basıncı (KB), rutin biyokimya, C-reaktif protein ve diğer hasta karakteristikleri ölçüldü. Tek değişkenli ve ardından çoklu lineer regresyon analizleri EAD ile bağımsız ilişkide olan değişkenlerin analizinde kullanıldı. Bulgular: Sol ventrikül kitlesi (SVK) bel çevresi, EAD, glikoz, ürik asit, yüksek-dansiteli lipoprotein (HDL) kolesterol, ve sistolik ve diyastolik kan basıncı ile anlamlı olarak ilişkiliydi. Çalışma popülasyonu ortanca ortalama kan basıncına göre iki gruba ayrıldığında (ortalama KB ≤116 vs. >116 mmHg), medyan KB değeri altındaki hastalarda EAD SVK’nin tek nedensel faktörüydü (Beta: 0.518, p<0.001). Lineer regresyon analizleri EAD’yi SVK (Beta: 0.419; p<0.001) ve SVK indeksi (Beta: 0.384, p<0.001) için HDL kolesterolün azaltıcı etkisi yanında (Beta: -0.264, p=0.006) tek bağımsız ilişkili değişken olarak belirledi. Sonuç: EAD hipertansiyon hastalarında artmış SVK ile VKİ, bel çevresi, kilo, sistolik ve diyastolik KB ve diğer risk parametrelerinden bağımsız olarak ilişkiliydi. Ekokardiyografi ile artmış EAD’un belirlenmesi total visseral yağ dokusu ve kardiyovasküler riskin öngörülmesinde bir belirteç olarak ek bir değere sahip olabilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Epikardiyal adipoz doku tedavi edilmemiş hipertansif hastalarda artmış sol ventrikül kitlesi ile bağımsız ilişkilidir: Gözlemsel bir çalışma

Öz:

Objective: Epicardial adipose tissue (EAT) secretes various inflammatory mediators and growth factor, and has endocrine and paracrine effects on myocardium and body. We planned the present study in order to evaluate the possible relationship between EAT and left ventricular mass (LVM), a potent predictor of cardiovascular mortality and morbidity, independent of age, blood pressure and the metabolic parameters in patients with hypertension (HT). Methods: The present study was cross-sectional and observational, including consecutive 107 untreated essential hypertensive patients who underwent a complete transthoracic echocardiographic examination as well as measurements of LVM and EAT. Blood pressure, routine blood chemistry, C-reactive protein, and patient characteristics were also recorded. Univariate and then multiple linear regression analyses were used for analysis of independent variables associated with EAT. Results: LVM significantly correlated with waist circumference, EAT, glucose, uric acid, high-density lipoprotein (HDL) cholesterol, and systolic and dia- stolic blood pressure. When we divided study population into two groups according to median mean blood pressure (BP) (Mean BP ≤116 vs. >116 mmHg), EAT was the only associated factor for LVM in patients below median BP (Beta: 0.518, p<0.001). Linear regression analyses revealed EAT to be indepen- dently associated with LVM (Beta: 0.419; p<0.001) and LVM index (Beta: 0.384, p<0.001) as well as high-density lipoprotein (Beta: -0.264, p=0.006). Conclusion: EAT was related to increased LVM independent of BMI, waist circumference, weight, systolic and diastolic blood pressure and other risk parameters, in patients with HT. Determination of increased EAT by echocardiography may have an additional value as an indicator of cardiovascular risk and total visceral adipose tissue.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ERDOĞAN T, ÇETİN M, KOCAMAN S, Durakoglugil M, Ergül E, UĞURLU Y, ÇANĞA A (2013). Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. , 320 - 327.
Chicago	ERDOĞAN Turan,ÇETİN Mustafa,KOCAMAN Sinan Altan,Durakoglugil Murtaza Emre,Ergül Elif,UĞURLU Yavuz,ÇANĞA Aytun Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. (2013): 320 - 327.
MLA	ERDOĞAN Turan,ÇETİN Mustafa,KOCAMAN Sinan Altan,Durakoglugil Murtaza Emre,Ergül Elif,UĞURLU Yavuz,ÇANĞA Aytun Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. , 2013, ss.320 - 327.
AMA	ERDOĞAN T,ÇETİN M,KOCAMAN S,Durakoglugil M,Ergül E,UĞURLU Y,ÇANĞA A Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. . 2013; 320 - 327.
Vancouver	ERDOĞAN T,ÇETİN M,KOCAMAN S,Durakoglugil M,Ergül E,UĞURLU Y,ÇANĞA A Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. . 2013; 320 - 327.
IEEE	ERDOĞAN T,ÇETİN M,KOCAMAN S,Durakoglugil M,Ergül E,UĞURLU Y,ÇANĞA A "Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study." , ss.320 - 327, 2013.
ISNAD	ERDOĞAN, Turan vd. "Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study". (2013), 320-327.

APA	ERDOĞAN T, ÇETİN M, KOCAMAN S, Durakoglugil M, Ergül E, UĞURLU Y, ÇANĞA A (2013). Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. Anadolu Kardiyoloji Dergisi, 13(4), 320 - 327.
Chicago	ERDOĞAN Turan,ÇETİN Mustafa,KOCAMAN Sinan Altan,Durakoglugil Murtaza Emre,Ergül Elif,UĞURLU Yavuz,ÇANĞA Aytun Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. Anadolu Kardiyoloji Dergisi 13, no.4 (2013): 320 - 327.
MLA	ERDOĞAN Turan,ÇETİN Mustafa,KOCAMAN Sinan Altan,Durakoglugil Murtaza Emre,Ergül Elif,UĞURLU Yavuz,ÇANĞA Aytun Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. Anadolu Kardiyoloji Dergisi, vol.13, no.4, 2013, ss.320 - 327.
AMA	ERDOĞAN T,ÇETİN M,KOCAMAN S,Durakoglugil M,Ergül E,UĞURLU Y,ÇANĞA A Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(4): 320 - 327.
Vancouver	ERDOĞAN T,ÇETİN M,KOCAMAN S,Durakoglugil M,Ergül E,UĞURLU Y,ÇANĞA A Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(4): 320 - 327.
IEEE	ERDOĞAN T,ÇETİN M,KOCAMAN S,Durakoglugil M,Ergül E,UĞURLU Y,ÇANĞA A "Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study." Anadolu Kardiyoloji Dergisi, 13, ss.320 - 327, 2013.
ISNAD	ERDOĞAN, Turan vd. "Epicardial adipose tissue is independently associated with increased left ventricular mass in untreated hypertensive patients: An observational study". Anadolu Kardiyoloji Dergisi 13/4 (2013), 320-327.