The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study

çiçek, yüksel gülen; CÜRE, Erkan; YÜCE, Süleyman; CÜRE, Medine Cumhur

The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study

Erkan CÜRE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Rize, Türkiye)

Süleyman YÜCE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Rize, Türkiye)

Yüksel ÇİÇEK, (Recep Tayyip Erdoğan Üniversitesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Medine Cumhur CÜRE (Recep Tayyip Erdoğan Üniversitesi, Tıp, Fakültesi Biyokimya, Bölümü, Rize, Türkiye)

Anadolu Kardiyoloji Dergisi

1 0

Yıl: 2013 Cilt: 13 Sayı: 6 Sayfa Aralığı: 559 - 565 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study

Öz:

Amaç: Gilbert sendromu (GS) aterosklerotik kalphastalığı sıklığını azaltır. Bu çalışmanın amacı P dalga dispersiyonu (Pd), QT dispersiyonu (QTd) gibi aritmi risk belirteçlerinin sağlıklı bireylerle kıyaslandığında GS’li hastalarda azalmış olup olmadığını değerlendirmektir. Yöntemler: Hastanemiz iç hastalıkları polikliniğine başvuran toplam 61 GS hastası (31 kadın, 30 erkek) kesitsel gözlemsel bu çalışmaya dahil edildi. Sigara içmeyen 61 sağlıklı (31 kadın, 30 erkek) kişi çalışmaya alındı. İki grup da 16-45 yaş grubu arasındaydı. Antropometrik ölçümler, laboratuvar ve elektrokardiyografik bulguların sonuçları her katılımcı için kaydedildi. Veri analizi için bağımsız örneklem t-testi ve kümelenmiş ANOVA kullanıldı. Bulgular: GS grubunda Pd 36±16,7 msec, QTd 48,7±10,7 msec ve kalp hızı (KH) 74±8 atım/dk idi. Kontrol grubunda Pd 51±28 msec, QTd 53±12 msec ve KH 78±10 atım/dk idi. Hasta grubunda Pd (p<0,001), QTd (p=0,038) ve KH (p=0,021) kontrol grubundan anlamlı düşük bulundu. Sonuç: Bizim çalışmamızın sonuçlarına göre, bu hastalarda artmış bilirubin düzeyi, KH, Pd ve QTd’de azalma ile ilişkilidir, bunun sonucu olarak kardiyak aritmi ve koroner arter hastalığı insidansı azalabilir. Bu kategorideki hastalarda aritmi riskinde bilirubinin koruyucu rolünü göstermek için daha kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

QT ve P dalga dispersiyonu üzerine Gilbert sendromunun etkisi: Gözlemsel bir çalışma

Öz:

Objective: Gilbert’s syndrome (GS) decreases the incidence of atherosclerotic heart disease. The aim of the study was to evaluate whether the arrhythmia risk markers such as P-wave dispersion (Pd), QT dispersion (QTd) are reduced in patients with GS compared with healthy subjects. Methods: Sixty-one patients diagnosed with GS (31 females, 30 males) who had applied to the internal medicine outpatient clinic in the hospital were included in this cross-sectional, observational study. A control group of 61 healthy persons (31 females, 30 males), who were non-smokers and drinkers, were included. Both groups were between 16-45 years old. Results of anthropometric measurements, laboratory assays and electrocardiographic findings were recorded for each participant. Independent sample t-test and nested ANOVA were used for data analysis. Results: In the GS group were Pd value 36±16.7 msec, QTd 48.7±10.7 msec and heart rate (HR) 74±8 beat/min. In the control group were Pd 51±28 msec, QTd 53±12 msec and HR 78±10 beat/min. The Pd of patients group (p<0.001), QTd (p=0.038) and HR (p=0.021) were significantly lower than the control group. Conclusion: According to our study’s results, in these patients, increased bilirubin levels are associated with decrease in HR, Pd and QTd, which consequently might decrease the incidence of cardiac arrhythmias and coronary artery disease. Further studies are needed to clarify the protective role of bilirubin in risk of arrhythmias in this category of patients.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	CÜRE E, YÜCE S, çiçek y, CÜRE M (2013). The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. , 559 - 565.
Chicago	CÜRE Erkan,YÜCE Süleyman,çiçek yüksel gülen,CÜRE Medine Cumhur The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. (2013): 559 - 565.
MLA	CÜRE Erkan,YÜCE Süleyman,çiçek yüksel gülen,CÜRE Medine Cumhur The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. , 2013, ss.559 - 565.
AMA	CÜRE E,YÜCE S,çiçek y,CÜRE M The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. . 2013; 559 - 565.
Vancouver	CÜRE E,YÜCE S,çiçek y,CÜRE M The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. . 2013; 559 - 565.
IEEE	CÜRE E,YÜCE S,çiçek y,CÜRE M "The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study." , ss.559 - 565, 2013.
ISNAD	CÜRE, Erkan vd. "The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study". (2013), 559-565.

APA	CÜRE E, YÜCE S, çiçek y, CÜRE M (2013). The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. Anadolu Kardiyoloji Dergisi, 13(6), 559 - 565.
Chicago	CÜRE Erkan,YÜCE Süleyman,çiçek yüksel gülen,CÜRE Medine Cumhur The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. Anadolu Kardiyoloji Dergisi 13, no.6 (2013): 559 - 565.
MLA	CÜRE Erkan,YÜCE Süleyman,çiçek yüksel gülen,CÜRE Medine Cumhur The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. Anadolu Kardiyoloji Dergisi, vol.13, no.6, 2013, ss.559 - 565.
AMA	CÜRE E,YÜCE S,çiçek y,CÜRE M The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(6): 559 - 565.
Vancouver	CÜRE E,YÜCE S,çiçek y,CÜRE M The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(6): 559 - 565.
IEEE	CÜRE E,YÜCE S,çiçek y,CÜRE M "The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study." Anadolu Kardiyoloji Dergisi, 13, ss.559 - 565, 2013.
ISNAD	CÜRE, Erkan vd. "The effect of Gilbert’s syndrome on the dispersions of QT interval and P-wave: an observational study". Anadolu Kardiyoloji Dergisi 13/6 (2013), 559-565.