Impaired heart rate variability in patients with mitral annular calcification: An observational study

pekdemir, hasan; ÇUĞLAN, BİLAL; ERDAL, Erdal; ATAŞ, Halil; KURTOĞLU, Ertuğrul; KORKMAZ, HASAN

Impaired heart rate variability in patients with mitral annular calcification: An observational study

Ertuğrul KURTOĞLU, (Elazığ Eğitim ve Araştırma Hastanesi, Kardiyoloji Anabilim Dalı, Elazığ, Türkiye)

Erdal AKTÜRK, (Adıyaman Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Adıyaman, Türkiye)

Hasan KORKMAZ, (Elazığ Eğitim ve Araştırma Hastanesi, Kardiyoloji Anabilim Dalı, Elazığ, Türkiye)

Halil ATAŞ, (İnönü Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Malatya, Türkiye)

Bilal ÇUĞLAN, (İnönü Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Malatya, Türkiye)

Hasan PEKDEMİR (İnönü Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Malatya, Türkiye)

Anadolu Kardiyoloji Dergisi

2 2

Yıl: 2013 Cilt: 13 Sayı: 7 Sayfa Aralığı: 668 - 674 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Impaired heart rate variability in patients with mitral annular calcification: An observational study

Öz:

Amaç: Çalışmanın amacı mitral annüler kalsifikasyonu (MAK) olan hastalarda kalp hızı değişkenliği (KHD) parametrelerini incelemektir. Yöntemler: Çalışma enine kesitli gözlemsel amaçlı planlandı. Ekokardiyografik olarak MAK tespit edilmiş 50 hasta ile MAK'ı olmayan 50 hasta çalışmaya dahil edildi. Tüm hastalara iki boyutlu transtorasik ekokardiyografi ve KHD analizi için 24 saatlik Holter monitorizasyonu uygulandı. İstatistiksel analiz için Student-t, Mann-Whitney U ve Ki-kare testleri kullanıldı. Bulgular: Hipertansiyon ve koroner arter hastalığı MAK grubunda kontrol grubuna göre daha yüksekti. Ortalama RR süresi, SDNN, SDANN, SDNN indeksi, pNN50 ve RMSSD’yi içeren tüm HRV parametreleri MAK grubunda kontrol grubuna göre azalmış saptandı (p<0,05). Hipertansiyon alt grubunda, ortalama RR süresi dışında diğer tüm HRV parametreleri MAK’lı hastalarda MAK’ı olmayanlara göre azalmış saptandı. Hipertansiyon olmayan hasta alt grubunda ise, tüm HRV parametreleri MAK’lı hastalarda MAK’ı olmayanlara göre yine azalmış saptandı (p<0,05). Koroner arter hastalığı olan hastaların alt grubunda, ortalama RR süresi, pNN50 ve RMSSD dışında tüm HRV parametreleri MAK’lı hastalarda MAK’ı olmayanlara göre düşük saptandı (p<0,05). Koroner arter hastalığı olmayan hastaların alt grubunda ise tüm HRV parametrelerinin MAK’lı hastalarda MAK’ı olmayanlara göre düşük olduğu saptandı (p<0,05). Sonuç: Bu çalışmadaki bulgular MAK'lı hastalarda azalmış parasempatik aktiviteyle birlikte artmış sempatik aktivasyona işaret eden baskılan- mış KHD'yi göstermektedir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Mitral annüler kalsifikasyonlu hastalarda azalmış kalp hızı değişkenliği: Gözlemsel bir çalışma

Öz:

Objective: The aim of the present study was to study time indices of heart rate variability (HRV) in patients with mitral annular calcification (MAC). Methods: A cross-sectional observational study was performed. Fifty patients with echocardiographic evidence of MAC and 50 age- and gen- der-matched control subjects without echocardiographic evidence of MAC were included. All the study participants underwent 2-dimensional echocardiographic examinations and 24-hour Holter monitoring for HRV analysis. Student-t, Mann-Whitney U and Chi-square tests were used for statistical analysis. Results: Hypertension and coronary artery disease were more common in the MAC group than in the control group. All HRV parameters includ- ing mean RR interval, SDNN, SDANN, SDNN index, pNN50 and RMSSD were reduced in the MAC group when compared with the control group (p<0.05 for all). In hypertensive subgroup, all HRV parameters except mean RR interval were diminished in patients with MAC when compared with those without MAC (p<0.05 for all). In non-hypertensive subgroup, all HRV parameters were also diminished in patients with MAC when compared with those without MAC. In the subgroup of patients with coronary artery disease, patients had lower HRV parameters except mean RR interval, pNN50 and RMSSD in comparison to those without MAC (p<0.05 for all). In the subgroup of patients without coronary artery disease, all HRV parameters were depressed in patients with MAC in comparison to those without MAC (p<0.05 for all). Conclusion: Our findings indicate that MAC was associated with reduced heart rate variability which possibly reflects decreased parasympa- thetic tone with a predominant activity of the sympathetic tone. (

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KURTOĞLU E, ERDAL E, KORKMAZ H, ATAŞ H, ÇUĞLAN B, pekdemir h (2013). Impaired heart rate variability in patients with mitral annular calcification: An observational study. , 668 - 674.
Chicago	KURTOĞLU Ertuğrul,ERDAL Erdal,KORKMAZ HASAN,ATAŞ Halil,ÇUĞLAN BİLAL,pekdemir hasan Impaired heart rate variability in patients with mitral annular calcification: An observational study. (2013): 668 - 674.
MLA	KURTOĞLU Ertuğrul,ERDAL Erdal,KORKMAZ HASAN,ATAŞ Halil,ÇUĞLAN BİLAL,pekdemir hasan Impaired heart rate variability in patients with mitral annular calcification: An observational study. , 2013, ss.668 - 674.
AMA	KURTOĞLU E,ERDAL E,KORKMAZ H,ATAŞ H,ÇUĞLAN B,pekdemir h Impaired heart rate variability in patients with mitral annular calcification: An observational study. . 2013; 668 - 674.
Vancouver	KURTOĞLU E,ERDAL E,KORKMAZ H,ATAŞ H,ÇUĞLAN B,pekdemir h Impaired heart rate variability in patients with mitral annular calcification: An observational study. . 2013; 668 - 674.
IEEE	KURTOĞLU E,ERDAL E,KORKMAZ H,ATAŞ H,ÇUĞLAN B,pekdemir h "Impaired heart rate variability in patients with mitral annular calcification: An observational study." , ss.668 - 674, 2013.
ISNAD	KURTOĞLU, Ertuğrul vd. "Impaired heart rate variability in patients with mitral annular calcification: An observational study". (2013), 668-674.

APA	KURTOĞLU E, ERDAL E, KORKMAZ H, ATAŞ H, ÇUĞLAN B, pekdemir h (2013). Impaired heart rate variability in patients with mitral annular calcification: An observational study. Anadolu Kardiyoloji Dergisi, 13(7), 668 - 674.
Chicago	KURTOĞLU Ertuğrul,ERDAL Erdal,KORKMAZ HASAN,ATAŞ Halil,ÇUĞLAN BİLAL,pekdemir hasan Impaired heart rate variability in patients with mitral annular calcification: An observational study. Anadolu Kardiyoloji Dergisi 13, no.7 (2013): 668 - 674.
MLA	KURTOĞLU Ertuğrul,ERDAL Erdal,KORKMAZ HASAN,ATAŞ Halil,ÇUĞLAN BİLAL,pekdemir hasan Impaired heart rate variability in patients with mitral annular calcification: An observational study. Anadolu Kardiyoloji Dergisi, vol.13, no.7, 2013, ss.668 - 674.
AMA	KURTOĞLU E,ERDAL E,KORKMAZ H,ATAŞ H,ÇUĞLAN B,pekdemir h Impaired heart rate variability in patients with mitral annular calcification: An observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(7): 668 - 674.
Vancouver	KURTOĞLU E,ERDAL E,KORKMAZ H,ATAŞ H,ÇUĞLAN B,pekdemir h Impaired heart rate variability in patients with mitral annular calcification: An observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(7): 668 - 674.
IEEE	KURTOĞLU E,ERDAL E,KORKMAZ H,ATAŞ H,ÇUĞLAN B,pekdemir h "Impaired heart rate variability in patients with mitral annular calcification: An observational study." Anadolu Kardiyoloji Dergisi, 13, ss.668 - 674, 2013.
ISNAD	KURTOĞLU, Ertuğrul vd. "Impaired heart rate variability in patients with mitral annular calcification: An observational study". Anadolu Kardiyoloji Dergisi 13/7 (2013), 668-674.