The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study

çiçek, yüksel gülen; YILMAZ, Arif; CÜRE, Erkan; Kırbaş, Aynur; CÜRE, Medine Cumhur; YÜCE, Süleyman

The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study

Erkan CÜRE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Rize, Türkiye)

Yüksel ÇİÇEK, (Recep Tayyip Erdoğan Üniversitesi, Kardiyoloji Anabilim Dalı, Rize, Türkiye)

Medine Cumhur CÜRE, (Recep Tayyip Erdoğan Üniversitesi, Tıp, Fakültesi Biyokimya, Bölümü, Rize, Türkiye)

Süleyman YÜCE, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Rize, Türkiye)

Aynur KIRBAŞ, (Recep Tayyip Erdoğan Üniversitesi, Tıp, Fakültesi Biyokimya, Bölümü, Rize, Türkiye)

Arif YILMAZ (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Gastroenteroloji Kliniği, Rize, Türkiye)

Anadolu Kardiyoloji Dergisi

2 2

Yıl: 2013 Cilt: 13 Sayı: 8 Sayfa Aralığı: 791 - 796 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study

Öz:

Amaç: Gilbert sendromlu (GS) hastalarda aterosklerotik kalp hastalıkları daha az sıklıkla görülmektedir. Bilirubinin antioksidan etkisi yanında serum adiponektin (APN) ve epikardiyal yağ doku (EYD) kalınlığının aterosklerotik sürecin az görülmesinde etkisi olup olmadığını araştırmayı amaçladık. Yöntemler: Hastanemiz iç hastalıkları polikliniğine başvuran toplam 68 GS hastası (39 kadın, 29 erkek) bu kesitsel gözlemsel çalışmaya dahil edildi. Kontrol grubuna 63 sağlıklı birey (39 kadın, 24 erkek) alındı. EYD kalınlığı ekokardiyografi ile ölçüldü. Serum APN seviyeleri de ölçüldü. İstatistiksel analizde bağımsız örneklem t-testi, Pearson korelasyon ve lineer regresyon analizi kullanıldı. Bulgular: GS hastalarda ortalama yaş 28±9 yıl ve ortalama EYD kalınlığı 2,5±0,1 mm bulundu. Kontrol grubunun yaş ortalaması 26±6 yıl ve orta- lama EYD kalınlığı 4,2±0,5 mm bulundu. İki grup karşılaştırıldığında GS grubunda EYD kalınlığı kontrol grubundan anlamlı düşük bulundu (p<0,001). GS grubunda APN 14.94 mg/L ve kontrol grubunda APN 12,64 mg/L idi (p<0,022). Total bilirubin (β=-1,607, p<0,001) ve indirekt bilirubin (β=1,086, p<0,001) ile azalmış EYD kalınlığı arasında bağımsız bir ilişki olduğunu bulduk. Sonuç: EYD kalınlığı koroner ateroskleroz ile ilişkilidir. EYD kalınlığı azlığı pro-enflamatuvar sitokinlerin salınım azlığı ile ilişkili olabilir. APN sevi- yeleri yüksekliği ile yüksek anti-enflamatuvar etki ilişkili olabilir. Sonuç olarak EYD kalınlığı azlığı ve APN yüksek seviyesi GS hastalarında ate- rosklerotik kalp hastalığı üzerine bu parametrelerin koruyucu etkisi olduğunu gösterebilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Gilbert sendromlu hastalarda epikardiyal yağ doku kalınlığı ve adiponektin seviyesinin düşük kardiyak riskle birlikteliğinin değerlendirilmesi: Gözlemsel bir çalışma

Öz:

Objective: Atherosclerotic heart diseases are less frequently seen in patients with Gilbert’s syndrome (GS). We aimed to investigate whether serum adiponectin (APN) and epicardial adipose tissue (EAT) thickness have an effect beside the antioxidant effect of bilirubin in lowering the incidence of the atherosclerotic process. Methods: Sixty-eight patients diagnosed with GS (39 females and 29 males) who had applied at the internal medicine clinic of the hospital were included in this cross-sectional, observational study. The control group included 63 healthy people (39 females and 24 males). EAT thickness was measured by echocardiography. The serum APN levels were also checked. Statistical analysis was performed by using independent sample t-test, Pearson correlation and linear regression analyses. Results: The mean age of the GS group was 28±9 years, and the average EAT thickness was found to be 2.5±0.1 mm. The mean age of the con- trol group was 26±6 years, and the average EAT thickness was found to be 4.2±0.5 mm. When comparing the two groups, the EAT thickness of the GS group was found to be significantly lower (p<0.001) than that of the control group. In the GS group the APN was 14.9±4.2 mg/L, and in the control group the APN was 12.6±4.5 mg/L (p<0.022). We found that total bilirubin (β=-1,607, p<0,001) and indirect bilirubin (β=1,086, p<0,001) have an independent association with decreased EAT thickness. Conclusion: EAT thickness is associated with coronary atherosclerosis. Low EAT thickness may be related with low release of proinflamma- tory cytokine. High levels of APN may be related high anti-inflammatory effect. Therefore, low EAT thickness and high levels of APN may dem- onstrate protective effect on atherosclerotic heart diseases in GS patients.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	CÜRE E, çiçek y, CÜRE M, YÜCE S, Kırbaş A, YILMAZ A (2013). The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. , 791 - 796.
Chicago	CÜRE Erkan,çiçek yüksel gülen,CÜRE Medine Cumhur,YÜCE Süleyman,Kırbaş Aynur,YILMAZ Arif The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. (2013): 791 - 796.
MLA	CÜRE Erkan,çiçek yüksel gülen,CÜRE Medine Cumhur,YÜCE Süleyman,Kırbaş Aynur,YILMAZ Arif The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. , 2013, ss.791 - 796.
AMA	CÜRE E,çiçek y,CÜRE M,YÜCE S,Kırbaş A,YILMAZ A The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. . 2013; 791 - 796.
Vancouver	CÜRE E,çiçek y,CÜRE M,YÜCE S,Kırbaş A,YILMAZ A The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. . 2013; 791 - 796.
IEEE	CÜRE E,çiçek y,CÜRE M,YÜCE S,Kırbaş A,YILMAZ A "The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study." , ss.791 - 796, 2013.
ISNAD	CÜRE, Erkan vd. "The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study". (2013), 791-796.

APA	CÜRE E, çiçek y, CÜRE M, YÜCE S, Kırbaş A, YILMAZ A (2013). The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. Anadolu Kardiyoloji Dergisi, 13(8), 791 - 796.
Chicago	CÜRE Erkan,çiçek yüksel gülen,CÜRE Medine Cumhur,YÜCE Süleyman,Kırbaş Aynur,YILMAZ Arif The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. Anadolu Kardiyoloji Dergisi 13, no.8 (2013): 791 - 796.
MLA	CÜRE Erkan,çiçek yüksel gülen,CÜRE Medine Cumhur,YÜCE Süleyman,Kırbaş Aynur,YILMAZ Arif The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. Anadolu Kardiyoloji Dergisi, vol.13, no.8, 2013, ss.791 - 796.
AMA	CÜRE E,çiçek y,CÜRE M,YÜCE S,Kırbaş A,YILMAZ A The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(8): 791 - 796.
Vancouver	CÜRE E,çiçek y,CÜRE M,YÜCE S,Kırbaş A,YILMAZ A The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(8): 791 - 796.
IEEE	CÜRE E,çiçek y,CÜRE M,YÜCE S,Kırbaş A,YILMAZ A "The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study." Anadolu Kardiyoloji Dergisi, 13, ss.791 - 796, 2013.
ISNAD	CÜRE, Erkan vd. "The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert's syndrome: an observational study". Anadolu Kardiyoloji Dergisi 13/8 (2013), 791-796.