The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis

ŞENER ,ELİF FUNDA; EMİROĞULLARI ,ÖMER NACİ; SERHATLIOĞLU ,FARUK; ÖZKUL ,YUSUF

ELİF FUNDA ŞENER

(Erciyes Üniversitesi, Tıp Fakültesi, Biyoloji Anabilim Dalı, Kayseri, Türkiye)

ÖMER NACİ EMİROĞULLARI

(Erciyes Üniversitesi, Tıp Fakültesi, Kardiyovasküler Cerrahi Anabilim Dalı, Kayseri, Türkiye)

FARUK SERHATLIOĞLU

(Erciyes Üniversitesi, Tıp Fakültesi, Kardiyovasküler Cerrahi Anabilim Dalı, Kayseri, Türkiye)

YUSUF ÖZKUL

(Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kayseri, Türkiye)

Anadolu Kardiyoloji Dergisi

Yıl: 2014Cilt: 14Sayı: 3ISSN: 1302-8723 / 1308-0032Sayfa Aralığı: 239 - 243Metin Dili: İngilizce

101 2

İngilizce

The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis

Abstract: Objective: Endothelial nitric oxide synthase (eNOS) gene is a candidate gene in cardiovascular and renal diseases. Several polymorphic varia- tions have been identified in eNOS gene. We investigated a potential role of arteriovenous fistula (AVF) thrombosis and intron 4 and G894T polymorphisms in chronic renal failure. Methods: We performed a case-control observational study involving 79 with/without AVF thrombosis in chronic renal failure patients. All sub- jects were genotyped by the polymerase chain reaction (PCR) and PCR-Restriction Fragment Length Polymorphism. Genotype distribution and allele frequencies were compared between groups using the chi-square test. Results: Genotype frequencies in patients with thrombosis were not significantly different from those of patients without thrombosis for eNOS G894T polymorphism (p=0.1). eNOS gene intron 4 a allele distributions seems to be associated with thrombosis in the groups. Conclusion: This study revealed that there was an association between eNOS intron 4 polymorphism and thrombosis in chronic renal failure patients. This data will be helpful in planning further eNOS association studies in vascular access thrombosis.

Keywords:

Subject Area: Fen > Tıp > Kalp ve Kalp Damar Sistemi

Belge Türü: DergiMakale Türü: Araştırma MakalesiErişim Formatı: Erişime Açık

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