ELİF FUNDA ŞENER
(Erciyes Üniversitesi, Tıp Fakültesi, Biyoloji Anabilim Dalı, Kayseri, Türkiye)
ÖMER NACİ EMİROĞULLARI
(Erciyes Üniversitesi, Tıp Fakültesi, Kardiyovasküler Cerrahi Anabilim Dalı, Kayseri, Türkiye)
FARUK SERHATLIOĞLU
(Erciyes Üniversitesi, Tıp Fakültesi, Kardiyovasküler Cerrahi Anabilim Dalı, Kayseri, Türkiye)
YUSUF ÖZKUL
(Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Kayseri, Türkiye)
Yıl: 2014Cilt: 14Sayı: 3ISSN: 1302-8723 / 1308-0032Sayfa Aralığı: 239 - 243İngilizce

101 2
The role of endothelial nitric oxide synthase gene G894T and intron 4 VNTR polymorphisms in hemodialysis patients with vascular access thrombosis
Objective: Endothelial nitric oxide synthase (eNOS) gene is a candidate gene in cardiovascular and renal diseases. Several polymorphic varia- tions have been identified in eNOS gene. We investigated a potential role of arteriovenous fistula (AVF) thrombosis and intron 4 and G894T polymorphisms in chronic renal failure. Methods: We performed a case-control observational study involving 79 with/without AVF thrombosis in chronic renal failure patients. All sub- jects were genotyped by the polymerase chain reaction (PCR) and PCR-Restriction Fragment Length Polymorphism. Genotype distribution and allele frequencies were compared between groups using the chi-square test. Results: Genotype frequencies in patients with thrombosis were not significantly different from those of patients without thrombosis for eNOS G894T polymorphism (p=0.1). eNOS gene intron 4 a allele distributions seems to be associated with thrombosis in the groups. Conclusion: This study revealed that there was an association between eNOS intron 4 polymorphism and thrombosis in chronic renal failure patients. This data will be helpful in planning further eNOS association studies in vascular access thrombosis.
Fen > Tıp > Kalp ve Kalp Damar Sistemi
DergiAraştırma MakalesiErişime Açık
  • 1. Tang FY, Liu FY, Xie XW. Association of angiotensin-converting enzyme and endothelial nitric oxide synthase gene polymorphisms with vascular disease in ESRD patients in a Chinese population. Mol Cell Biochem 2008; 319: 33-9. [CrossRef]
  • 2. Rao M, Jaber BL, Balakrishnan VS, DialGene Consortium. Gene polymorphism association studies in dialysis: cardiovascular disease. Semin Dial 2005; 18: 217-25. [CrossRef]
  • 3. Testa A, Spoto B, Sanguedolce MC, Parlongo RM, Pisano A, Tripepi G, et al. eNOS and caveolin-1 gene polymorphisms interaction and intima-media thickness: a proof of concept study in ESRD patients. Am J Hypertens 2012; 25: 103-8. [CrossRef]
  • 4. Bessias N, Paraskevas KI, Tziviskou E, Andrikopoulos V. Vascular access in elderly patients with end-stage renal disease. Int Urol Nephrol 2008; 40: 1133-42. [CrossRef]
  • 5. Brophy DF, Bukaveckas BL, Ferreira-Gonzales A, Archer KJ, Martin EJ, Gehr TWB. A pilot study of genetic polymorphisms and hemodialysis vascular access thrombosis. Hemodialysis International 2009; 13: 19-26. [CrossRef]
  • 6. Başaran O, Ataç FB, Karakayalı F, Aliosmanoğlu I, Yağmurdur MC, Özdemir FN, et al. Endothelial nitric oxide synthase gene intron 4 (VNTR) polymorphism and vascular access graft thrombosis. J Invest Surg 2007; 20: 49-53. [CrossRef]
  • 7. Girndt M, Heine GH, Ulrich C, Köhler H. Gene Polymorphism Association Studies in Dialysis: Vascular Access. Seminars in Dialysis 2007; 20: 63-7. [CrossRef]
  • 8. Colomba D, Duro G, Corrao S, Argano C, Di Chiara T, Nuzzo D, et al. Endothelial nitric oxide synthase gene polymorphisms and cardiovascular damage in hypertensive subjects: an Italian case- control study. Immun Ageing 2008; 29: 5: 4.
  • 9. Salimi S, Firoozrai M, Nourmohammadi I, Shabani M, Mohebbi A. Endothelial nitric oxide synthase gene intron 4 VNTR polymorphism in patients with coronary artery disease in Iran. Indian J Med Res 2006; 124: 683-8.
  • 10. Wattanapitayakul SK, Mihm MJ, Young AP Bauer JA. Therapeutic implication of human endothelial nitric oxide synthase gene polymorphism. Trends Pharmacol Sci 2001; 22: 361-8. [CrossRef]
  • 11. Buraczynska M, Ksiazek P Zaluska W, Nowicka T, Ksiazek A. Endothelial nitric oxide synthase gene intron 4 polymorphism in patients with end-stage renal disease. Nephrol Dial Transplant 2004; 19: 2302-6. [CrossRef]
  • 12. Bellini MH, Figueira MN, Piccoli MF, Marumo JT, Cendoroglo MS, Neto MC, et al. Association of endothelial nitric oxide synthase gene intron 4 polymorphism with end-stage renal disease. Nephrology (Carlton) 2007; 12: 289-93. [CrossRef]
  • 13. Akomolafe A, Lunetta KL, Erlich PM, Cupples LA, Baldwin CT, Huyck M, et al. Genetic association between endothelial nitric oxide synthase and Alzheimer disease. Clin Genet 2006; 70: 49-56. [CrossRef]
  • 14. Hingorani AD, Liang CF, Fatibene J, Lyon A, Monteith S, Parsons A, et al. A common variant of the endothelial nitric oxide synthase (glu298-asp) is a major risk factor for coronary artery disease in the UK. Circulation 1999; 100: 1515-20. [CrossRef]
  • 15. Balakrishnan VS, Rao M, Jaber BL, DialGene Consortium. Genomic medicine, gene polymorphisms, and human biological diversity. Semin Dial 2005; 18: 37-40.
  • 16. Casas JP Cavalleri GL, Bautista LE, Smeeth L, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: A HuGE Review. Am J Epidemiol 2006; 164: 921-35. [CrossRef]
  • 17. Sinici I, Karahan S, Atalar E. Distribution of endothelial nitric oxide synthase gene polymorphisms in Turkish population. J Investig Med 2009; 57: 769-76.
  • 18. Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab 2000; 70: 241-51. [CrossRef]
  • 19. Emiroğulları EF, Saatçi C, Ünal A, Şahin A, Özkul Y. Prothrombin, factor-V leiden, and plasminogen activator inhibitor Type 1 gene polymorphisms in hemodialysis patients with/without arteriovenous fistula thrombosis. Int J Nephrol Urol 2010; 2: 314-9.
  • 20. Güngör Y, Kayataş M, Yıldız G, Özdemir Ö, Candan F The presence of PAI-1 4G/5G and ACE DD genotypes increases the risk of early-stage AVF thrombosis in hemodialysis patients. Ren Fail 2011; 33: 169-75. [CrossRef]
  • 21. Heine GH, Ulrich C, Sester U, Sester M, Köhler H, Girndt M. Transforming growth factor beta1 genotype polymorphisms determine AV fistula patency in hemodialysis patients. Kidney Int 2003; 64: 1101-7. [CrossRef]
  • 22. Gorgi Y, Sfar I, Ben Abdallah T, Aouadi H, Abderrahim E, Bardi R, et al. Human platelet antigens polymorphisms and susceptibility of thrombosis in hemodialysis patients. Hemodial Int 2008; 12: 331-5. [CrossRef]
  • 23. Elshamaa MF, Sabry S, Badr A, El-Ahmady M, Elghoroury EA, Thabet EH, et al. Endothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with chronic kidney disease. Blood Coagul Fibrinolysis 2011; 22: 487-92. [CrossRef]
  • 24. Akçay A, Sezer S, Özdemir FN, Arat Z, Ataç FB, Verdi H, et al. Association of the Genetic Polymorphisms of the Renin-Angiotensin System and Endothelial Nitric Oxide Synthase With Chronic Renal Transplant Dysfunction. Transplantation 2004; 78: 892-8. [CrossRef]
  • 25. Nagase S, Suzuki H, Wang Y, Kikuchi S, Hirayama A, Ueda A, et al. Association of eNOS gene polymorphisms with end stage renal diseases. Mol Cell Biochem 2003; 244: 113-8. [CrossRef]
  • 26. Santos KG, Crispim D, Canani LH, Ferrugem PT, Gross JL, Roisenberg I. Association of eNOS gene polymorphisms with renal disease in Caucasians with type 2 diabetes. Diabetes Res Clin Pract 2011; 91: 353-62. [CrossRef]
  • 27. Suzuki H, Nagase S, Kikuchi S, Wang Y, Koyama A. Association of a missense Glu298Asp mutation of the endothelial nitric oxide synthase gene with end stage renal disease. Clin Chem 2000; 46: 1858-60.

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