Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery

KUTLAY, Oya; SELMİ HAS, Nazan; KAYA, Sener; GURBET, ALP; Yavaşcaoğlu, Belgin; kaya, Fatma nur; GUNEY, Ayla

Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery

Ayla GUNEY, (Uludağ Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Bursa, Türkiye)

Fatma Nur KAYA, (Uludağ Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Bursa, Türkiye)

Belgin YAVAŞCAOĞLU, (Uludağ Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Bursa, Türkiye)

Alp GURBET, (Uludağ Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Bursa, Türkiye)

Nazan SELMİ HAS, (Uludağ Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Bursa, Türkiye)

Sener KAYA, (Uludağ Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Bursa, Türkiye)

Oya KUTLAY (Uludağ Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Bursa, Türkiye)

Eurasian Journal of Medicine

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Yıl: 2012 Cilt: 44 Sayı: 2 Sayfa Aralığı: 99 - 105 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery

Öz:

Amaç: Çalışmamızın amacı nazal cerrahide esmolol ve nitrogliserininkontrollü hipotansiyon oluşturmadaki etkinliklerinin karşılaştırılma- sıdır. Gereç ve Yöntem: Etik kurul onayı alındıktan sonra 40 olgu rando- mize olarak, esmolol (Grup E) veya nitrogliserin (Grup N) şeklinde iki gruba ayrıldı. Grup E’de esmolol 30 sn içinde 500 μg/kg bolus dozverilerek idamede 25-300 μg/kg/dk ve Grup N’de nitrogliserin 0.5-2 μg/kg/dk infüzyon hızında sistolik arter basıncı 80 mmHg olacak şe-kilde uygulandı. Bulgular: Hipotansif dönemde sistolik arter basıncı, diastolik arter basıncı, ortalama arter basıncı ve kalp atım hızı değerlerinde Grup E’de %24, %33, %27 ve %35 (p<0.001, p<0.001, p<0.001, p<0.001), Grup N’de ise %30, %33, %34 ve %23 (p<0.001, p<0.001, p<0.001, p<0.001) azalma izlendi. Hipotansif dönemde kalp atım hızı değerle- rindeki azalma Grup E’de yüksekti (p=0.048). Derlenme döneminde Grup E’de diastolik arter basıncı ve kalp atım hızı değerlerinde %9 ve %18 azalma (p=0.044, p<0.001), Grup N’de ise sistolik arter basıncı, diastolik arter basıncı, ortalama arter basıncı değerlerinde %7, %3 ve %7 (p=0.049, p=0.451, p=0.045) azalma saptandı. Sonuç: Esmololun kontrollü hipotansiyonda benzer hemodinamik değişiklik ve iyi cerrahi görüş alanı sağlaması nedeni ile nitrogliserine alternatif olarak kullanılabileceği kanısındayız.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Nazal cerrahide kontrollü hipotansiyon sağlanmasında esmolol ile nitrogliserinin karşılaştırılması

Öz:

Objective: The aim of this study was to compare esmolol to nitroglycerine in terms of effectiveness in controlling hypotension duringnasal surgery.Materials and Methods: After approval by our institutional EthicsCommittee, 40 patients were recruited and randomized into twodrug groups: esmolol (Group E) and nitroglycerine (Group N). Ingroup E, a bolus dose of 500 μg/kg esmolol was administered over30 sec followed by continuous administration at a dose of 25-300 μg/ kg/min to maintain systolic arterial pressure at 80 mmHg. In group N, nitroglycerine was administered at a dose of 0.5-2 μg/kg/min.Results: During the hypotensive period, systolic arterial pressure, di- astolic arterial pressure, mean arterial pressure, and heart rate were decreased 24%, 33%, 27% and 35%, respectively, in group E (p<0.001, p<0.001, p<0.001, p<0.001) and were decreased 30%, 33%, 34% and 23%, respectively, in group N (p<0.001, p<0.001, p<0.001, p<0.001). The decrease in heart rate was higher in group E during the hypotensive period (p=0.048). During the recovery period, diastolic arterial pressure and heart rate were decreased 9% and 18%, respectively, in group E (p=0.044, p<0.001). Systolic arterial pressure, diastolic arte- rial pressure, and mean arterial pressure were decreased 7%, 3% and 7%, respectively, in group N (p=0.049, p=0.451, p=0.045). Conclusion: Esmolol provides hemodynamic stability and good surgical field visibility and should be considered as an alternative to nitroglycerine.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GUNEY A, kaya F, Yavaşcaoğlu B, GURBET A, SELMİ HAS N, KAYA S, KUTLAY O (2012). Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. , 99 - 105.
Chicago	GUNEY Ayla,kaya Fatma nur,Yavaşcaoğlu Belgin,GURBET ALP,SELMİ HAS Nazan,KAYA Sener,KUTLAY Oya Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. (2012): 99 - 105.
MLA	GUNEY Ayla,kaya Fatma nur,Yavaşcaoğlu Belgin,GURBET ALP,SELMİ HAS Nazan,KAYA Sener,KUTLAY Oya Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. , 2012, ss.99 - 105.
AMA	GUNEY A,kaya F,Yavaşcaoğlu B,GURBET A,SELMİ HAS N,KAYA S,KUTLAY O Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. . 2012; 99 - 105.
Vancouver	GUNEY A,kaya F,Yavaşcaoğlu B,GURBET A,SELMİ HAS N,KAYA S,KUTLAY O Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. . 2012; 99 - 105.
IEEE	GUNEY A,kaya F,Yavaşcaoğlu B,GURBET A,SELMİ HAS N,KAYA S,KUTLAY O "Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery." , ss.99 - 105, 2012.
ISNAD	GUNEY, Ayla vd. "Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery". (2012), 99-105.

APA	GUNEY A, kaya F, Yavaşcaoğlu B, GURBET A, SELMİ HAS N, KAYA S, KUTLAY O (2012). Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. Eurasian Journal of Medicine, 44(2), 99 - 105.
Chicago	GUNEY Ayla,kaya Fatma nur,Yavaşcaoğlu Belgin,GURBET ALP,SELMİ HAS Nazan,KAYA Sener,KUTLAY Oya Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. Eurasian Journal of Medicine 44, no.2 (2012): 99 - 105.
MLA	GUNEY Ayla,kaya Fatma nur,Yavaşcaoğlu Belgin,GURBET ALP,SELMİ HAS Nazan,KAYA Sener,KUTLAY Oya Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. Eurasian Journal of Medicine, vol.44, no.2, 2012, ss.99 - 105.
AMA	GUNEY A,kaya F,Yavaşcaoğlu B,GURBET A,SELMİ HAS N,KAYA S,KUTLAY O Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. Eurasian Journal of Medicine. 2012; 44(2): 99 - 105.
Vancouver	GUNEY A,kaya F,Yavaşcaoğlu B,GURBET A,SELMİ HAS N,KAYA S,KUTLAY O Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery. Eurasian Journal of Medicine. 2012; 44(2): 99 - 105.
IEEE	GUNEY A,kaya F,Yavaşcaoğlu B,GURBET A,SELMİ HAS N,KAYA S,KUTLAY O "Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery." Eurasian Journal of Medicine, 44, ss.99 - 105, 2012.
ISNAD	GUNEY, Ayla vd. "Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery". Eurasian Journal of Medicine 44/2 (2012), 99-105.