Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals

Avci, Okan; DEĞİRMENCİ OSANMAZ, Pelin; AKKOYUN, Dursun Çayan; ALPSOY, Şeref; Akyüz, Aydın; Oran, Mustafa; METE, RAFET

Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals

Aydın AKYÜZ, (Namık Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Rafet METE, (Namık Kemal Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Tekirdağ, Türkiye)

Mustafa ORAN, (Namık Kemal Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Tekirdağ, Türkiye)

Şeref ALPSOY, (Namık Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Dursun Çayan AKKOYUN, (Namık Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Pelin DEĞİRMENCİ OSANMAZ, (Namık Kemal Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Tekirdağ, Türkiye)

Okan AVCI (Namık Kemal Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Tekirdağ, Türkiye)

Koşuyolu Heart Journal

1 0

Yıl: 2014 Cilt: 17 Sayı: 1 Sayfa Aralığı: 1 - 6 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals

Öz:

Giriş: Sitotoksin ilişkili A genli Helicobacter pylori (SİAGHP), en çok virülansı olan H. pylori tipidir ve halen endotelyal disfonksiyon ile ilişkisi belirsizdir. Bu nedenle biz SİAGHP’nin endotelyal bağımlı dilatasyon üzerine etkilerini ve C-reaktif protein (CRP) düzeyleri ile ilişkisini normotansif bireylerde araştırdık. Hastalar ve Yöntem: SİAGHP enfeksiyonu olan 60 kişi, sitotoksin ilişkili A geni negatif H. pylori (SAİGNHP) enfeksiyonlu 40 kişi ve enfeksiyonu olmayan 50 kişi ile akım aracılı dilatasyon (AAD), endotele bağımlı olmayan dilatasyon (EBOD) ve CRP düzeyleri yönünden karşılaştırıldı. Bulgular: SİAGHP’li bireylerde ortalama AAD’nin yüzdesi (6,3±2,7) SİAGNHP olanlardan (9,8±3,3, p<0,01) ve enfekte olmayan kontrol grubundan (10,1±2,6, p<0,01) belirgin olarak düşüktü. CRP’nin ortalama düzeyleri SİAGHP’li bireylerde 3,9 mg/dL (0,1-9,8 aralığında), SİAGNHP olanlardan (2,3 mg/dL, 0,1-5,4 aralığında, p=0,01) ve enfekte olmayan kontrol grubundan (1,9 mg/dL, 0,1-5,3 aralığında, p<0,01) daha yüksek idi. SİAGHP’li bireylerde CRP düzeyleri AAD ile ters korelasyon gösterdi (r=0,318, p=0,013), fakat EBOD ile bu korelasyon görülmedi. Sonuç: Azalmış AAD ve düşük düzeyde inflamasyon SİAGHP enfeksiyonu ile ilişkilidir, ancak SİAGNHP ile ilişkili değildir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Sitotoksin ilişkili A+ genli helicobacter pylori enfeksiyonu normotansif bireylerde endotelyal disfonksiyon ile ilişkilidir

Öz:

Introduction: Cytotoxin associated gene (Cag) A+ Helicobacter pylori (HP) is the most virulent HP strain, and its association with endothelial dysfunction remains unclear. Thus we investigated the effects of CagA+ HP on endothelial dependent dilatation and its relationship with C-reactive protein (CRP) in normotensive subjects. Patients and Methods: Sixty individuals with CagA+ HP infection were compared with 40 individuals with CagA(-) HP infection and 50 individuals with no infection in terms of flow-mediated dilatation (FMD), non- endothelium-dependent dilatation (NED) and CRP. Results: In the CagA+ subjects the mean percentage of FMD was 6.3±2.7, which was significantly lower than that of the CagA- subjects (9.8±3.3, p<0.01) and the uninfected controls (10.1±2.6, p<0.01). The mean level of CRP in the CagA+ subjects was 3.9 mg/dL (range 0.1-9.8), which was significantly higher than that of the CagA- subjects (2.3 mg/dL, range 0.1-5.4, p=0.01) and the uninfected controls (1.9 mg/dL, range 0.1-5.3, p<0.01). In the CagA+ group CRP levels were inversely correlated with FMD (r=0.318, p=0.013), however not with non-endothelium- dependent dilatation (NED) (r=0.216, p=0.097). Conclusion: Attenuated FMD and low-grade inflammation were associated with CagA+ infection, however not with CagA(-) infection

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Akyüz A, METE R, Oran M, ALPSOY Ş, AKKOYUN D, DEĞİRMENCİ OSANMAZ P, Avci O (2014). Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. , 1 - 6.
Chicago	Akyüz Aydın,METE RAFET,Oran Mustafa,ALPSOY Şeref,AKKOYUN Dursun Çayan,DEĞİRMENCİ OSANMAZ Pelin,Avci Okan Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. (2014): 1 - 6.
MLA	Akyüz Aydın,METE RAFET,Oran Mustafa,ALPSOY Şeref,AKKOYUN Dursun Çayan,DEĞİRMENCİ OSANMAZ Pelin,Avci Okan Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. , 2014, ss.1 - 6.
AMA	Akyüz A,METE R,Oran M,ALPSOY Ş,AKKOYUN D,DEĞİRMENCİ OSANMAZ P,Avci O Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. . 2014; 1 - 6.
Vancouver	Akyüz A,METE R,Oran M,ALPSOY Ş,AKKOYUN D,DEĞİRMENCİ OSANMAZ P,Avci O Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. . 2014; 1 - 6.
IEEE	Akyüz A,METE R,Oran M,ALPSOY Ş,AKKOYUN D,DEĞİRMENCİ OSANMAZ P,Avci O "Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals." , ss.1 - 6, 2014.
ISNAD	Akyüz, Aydın vd. "Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals". (2014), 1-6.

APA	Akyüz A, METE R, Oran M, ALPSOY Ş, AKKOYUN D, DEĞİRMENCİ OSANMAZ P, Avci O (2014). Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. Koşuyolu Heart Journal, 17(1), 1 - 6.
Chicago	Akyüz Aydın,METE RAFET,Oran Mustafa,ALPSOY Şeref,AKKOYUN Dursun Çayan,DEĞİRMENCİ OSANMAZ Pelin,Avci Okan Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. Koşuyolu Heart Journal 17, no.1 (2014): 1 - 6.
MLA	Akyüz Aydın,METE RAFET,Oran Mustafa,ALPSOY Şeref,AKKOYUN Dursun Çayan,DEĞİRMENCİ OSANMAZ Pelin,Avci Okan Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. Koşuyolu Heart Journal, vol.17, no.1, 2014, ss.1 - 6.
AMA	Akyüz A,METE R,Oran M,ALPSOY Ş,AKKOYUN D,DEĞİRMENCİ OSANMAZ P,Avci O Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. Koşuyolu Heart Journal. 2014; 17(1): 1 - 6.
Vancouver	Akyüz A,METE R,Oran M,ALPSOY Ş,AKKOYUN D,DEĞİRMENCİ OSANMAZ P,Avci O Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals. Koşuyolu Heart Journal. 2014; 17(1): 1 - 6.
IEEE	Akyüz A,METE R,Oran M,ALPSOY Ş,AKKOYUN D,DEĞİRMENCİ OSANMAZ P,Avci O "Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals." Koşuyolu Heart Journal, 17, ss.1 - 6, 2014.
ISNAD	Akyüz, Aydın vd. "Cytotoxin associated gene A+ helicobacter pylori ınfection is related with endothelial dysfunction in normotensive ındividuals". Koşuyolu Heart Journal 17/1 (2014), 1-6.