Pethidine, the first synthetic opi- oid analgesic, was developed as a potential antispasmodic agent. Pethidine is used to treat mode- rate to severe pain. It is safer than morphine and carries less risk for addiction. Pethidine overdose can cause respiratory depression or coma. The case we present is a 34 years old male doctor found dead in his room at the hospital. Doctor was found dead sitting on an armchair where there was a used 100 mg Aldolan (Pethidine) ampoule and an injector. According to informa- tion taken from his relatives, he had been operated for cervical disc hernia a few years ago and complaining about headaches af- ter operation. He had been frequ- ently using oral analgesic drugs because of his headaches. In the microscopic examination, there were thrombi in the lumens of pulmonary artery branches, arterioles and capillaries. A de- tailed medical history, a systemic autopsy, histopathological exami- nation and toxicological analysis revealed that the cause of death was the pethidine-related res- piratory arrest. In this study, we wanted to point out that drug usage in patients should be un- der supervision of a doctor even if they are health care workers.