Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification
Yıl: 2013 Cilt: 8 Sayı: 2 Sayfa Aralığı: 111 - 115 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification
Öz: Amaç: Fakoemülsifikasyon cerrahisi sonrası göz içi basıncı (GİB) yükselmesinin önlenmesinde dorzolamide-timolol sabit kombinasyonu (DTSK) ile brimonidine-timolol sabit kombinasyonu (BTSK)’nun etkinliklerinin karşılaştırılması. Gereç ve Yöntem: Fakoemülsifikasyon cerrahisine giden 150 hastanın 150 gözü bu çalışmaya dahil edildi. Hastalar cerra- hiden hemen sonra damlatılan damlalara göre rastgele üç gruba ayrıldı; DTSK grubuna 1 damla DTSK, BTSK grubuna 1 damla BTSK ve kontrol grubuna 1 damla suni gözyaşı damlatıldı. GİB her hasta için ameliyattan hemen önce ve ameliyat sonrası 6. saat, 24. saat ve 7. günlerde ölçüldü. Bulgular: Ortalama GİB değerleri 6. ve 24. saatlerde DTSK ve BTSK gruplarında kontrol grubuna göre anlamlı derecede düşüktü (p<0.001). Ancak her iki tedavi grubunda takip süresi boyunca anlamlı bir fark yoktu. Sonuç: Bu çalışma, işlem sonrası damlatılan bir damla DTSK veya BTSK’nın her ikisinin de fakoemulsifiakasyon cerrahisi sonrası GİB artışının önlenmesinde etkin olduğu ve benzer etkiye sahip olduklarını gösterdi.
Anahtar Kelime: Konular:
Fakoemülsifikasyon sonrası göz içi basıncı artışı tedavisinde brimonidin-timolol ile dorzolamide-timolol’ün karşılaştırılması
Öz: Purpose: To compare the efficacies of fixed combination dorzolamide-timolol (FCDT) and fixed combination brimonidine- timolol (FCBT) for preventing intraocular pressure (IOP) spikes after phacoemulsification surgery. Materials and Methods: One hundred and fifty eyes of 150 patients undergoing phacoemulsification surgery were enrolled in this study. Patients were randomly divided preoperatively into three groups according to the drug that instilled immedi- ately after surgery; FCDT group that receiving one drop of FCDT, FCBT group that receiving one drop of FCBT and control group that receiving one drop of artificial tear. IOP was recorded immediately before surgery (baseline), at the 6th hour, 24th hour and 7th day postoperatively. Results: Mean IOP levels were significantly lower in the treatment groups than in the control group at the 6th and 24th hours (both p<0.001) after surgery whereas there was no significant difference between the treatment groups during the follow-up period. Conclusion: Our study has demonstrated that both FCDT and FCBT, each one drop administered immediately after proce- dure, were effective and both had similar efficacy for preventing IOP elevation after phacoemulsification surgery.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
- 1. Kooner KS, Cooksey JC, Perry P et al. Intraocular pressure following ECCE, phacoemulsification, and PC-IOL implanta- tion. Ophthalmic Surg 1988;19:643-6. 2. Katsimpris JM, Siganos D, Konstas AG, et al. Efficacy of bri- monidine 0.2% in controlling acute postoperative intraocular pressure elevation after phacoemulsification. J Cataract Re- fract Surg 2003;29:2288-94. 3. Whitehouse G. Brimonidine and postoperative pressure spikes in cataract surgery. Clin Exp Ophthalmol 2000;27:1227-31. 4. Hayreh SS. Anterior ischemic optic neuropathy. IV. Occurrence after cataract extraction. Arch Ophthalmol 1980;98:1410-6. 5. Savage JA, Thomas JV, Belcher CD 3rd, et al. Extracapsular cat- aract extraction and posterior chamber intraocular lens implan- tation in glaucomatous eyes. Ophthalmology 1985;92:1506-16. 6. Chan FM, Mathur R, Ku JJ, et al. Short-term outcomes in eyes with posterior capsule rupture during cataract surgery. J Cataract Refract Surg 2003;29:537-41. 7. Francis BA, Du LT, Berke S, et al. Cosopt Study Group. Com- paring the fixed combination dorzolamide-timolol (Cosopt) to concomitant administration of 2% dorzolamide (Trusopt) and 0.5% timolol. A randomized controlled trial and a replacement study. J Clin Pharm Ther 2004;29:375-80. 8. Hutzelmann J, Owens S, Shedden A, et al. Comparison of the safety and efficacy of the fixed combination of dorzolamide/ timolol and the concomitant administration of dorzolamide and timolol: a clinical equivalence study. International Clinical Equivalence Study Group. Br J Ophthalmol 1998;82:1249-53. 9. Konstas AG, Quaranta L, Yan DB, et al. Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination com- pared with the brimonidine/timolol-fixed combination in pri- mary open-angle glaucoma. Eye (Lond) 2012;26:80-7. 10. Yüksel N, Gök M, Altıntaş O, et al. Diurnal intraocular pres- sure efficacy of the timolol-brimonidine fixed combination and the timolol-dorzolamide fixed combination as a first choice therapy in patients with pseudoexfoliation glaucoma. Curr Eye Res 2011;36:804-8. 11. Hatanaka M, Grigera DE, Barbosa WL, et al. An eight-week, mul- ticentric, randomized, interventional, open-label, phase 4, paralel comparison of the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/dorzolamide 2% in patients with elevated intraocular pressure. J Glaucoma 2008;17:674-9. 2. Arcieri ES, Arcieri RS, Pereira AC, et al. Comparing the fixed combination brimonidine-timolol versus fixed combination dorzolamide-timolol in patients with elevated intraocular pressure. Curr Med Res Opin 2007; 23:683-689. 13. Rainer G, Menapace R, Findl O, et al. Intraindividual compar- ison of the effects of a fixed dorzolamide-timolol combination and latanoprost on intraocular pressure after small incision cataract surgery. J Cataract Refract Surg 2001;27:706-10. 14. Rainer G, Menapace R, Findl O, et al. Effect of a fixed dor- zolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat. J Cataract Re- fract Surg 2003;29:1748-52. 15. Razeghinejad MR, Sawchyn AK, Katz LJ. Fixed combina- tions of dorzolamide-timolol and brimonidine-timolol in the management of glaucoma. Expert Opin Pharmacother 2010;11:959-68. 16. Toris CB, Camras CB, Yablonski ME. Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular hypertensive patients. Am J Ophthalmol 1999;128:8-14. 17. Shingleton BJ, Wadhwani RA, O’Donoghue MW, et al. Evalu- ation of intraocular pressure in the immediate period after phacoemulsification. J Cataract Refract Surg 2001;27:524-7. 18. Kratky V, Feldman F. Effect of extracapsular cataract extrac- tion on intraocular pressure. Can J Ophthalmol 1988;23:111-3. 19. Naeser K, Thim K, Hansen TE, et al. Intraocular pressure in the first days after implantation of posterior chamber lenses with the use of sodium hyaluronate (Healon). Acta Ophthal- mol (Copenh) 1986;64:330-7. 20. Fry LL. Comparison of the postoperative intraocular pressure with Betagan, Betoptic, Timoptic, Iopidine, Diamox, Pilopine Gel, and Miostat. J Cataract Refract Surg 1992;18:14-9. 21. Byrd S, Singh K. Medical control of intraocular pressure after cataract surgery. J Cataract Refract Surg 1998;24:1493-7. 22. Ruiz RS, Rhem MN, Prager TC. Effects of carbachol and ace- tylcholine on intraocular pressure after cataract extraction. Am J Ophthalmol 1989;107:7-10. 23. Onal S, Gozum N, Gucukoglu A. Effect of apraclonidine ver- sus dorzolamide on intraocular pressure after phacoemulsifi- cation. Ophthalmic Surg Lasers Imaging 2005;36:457-62. 24. Dayanir V, Ozcura F, Kir E, et al. Medical control of intra- ocular pressure after phacoemulsification. J Cataract Refract Surg 2005;31:484-8. 25. Abbasoglu E, Tekeli O, Celikdogan A, et al. A topical or oral carbonic anhydrase inhibitor to control ocular hypertension after cataract surgery. Eur J Ophthalmol 2000;10:27-31. 26. Scherer WJ, Mielke DL, Tidwell PE, et al. Effect of latano- prost on intraocular pressure following cataract extraction. J Cataract Refract Surg 1998;24:964-7. 27. Ozkurt Y, Oral Y, Karacan O, et al. Comparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgery. Eye Contact Lens 2008;34:21-3.
| APA | ÖNER V, Alakuş M, taş m, İŞÇAN Y, TÜRKYILMAZ K, DURMUS M (2013). Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. , 111 - 115. |
| Chicago | ÖNER Veysi,Alakuş Mehmet Fuat,taş mehmet,İŞÇAN Yalçın,TÜRKYILMAZ Kemal,DURMUS MUSTAFA Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. (2013): 111 - 115. |
| MLA | ÖNER Veysi,Alakuş Mehmet Fuat,taş mehmet,İŞÇAN Yalçın,TÜRKYILMAZ Kemal,DURMUS MUSTAFA Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. , 2013, ss.111 - 115. |
| AMA | ÖNER V,Alakuş M,taş m,İŞÇAN Y,TÜRKYILMAZ K,DURMUS M Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. . 2013; 111 - 115. |
| Vancouver | ÖNER V,Alakuş M,taş m,İŞÇAN Y,TÜRKYILMAZ K,DURMUS M Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. . 2013; 111 - 115. |
| IEEE | ÖNER V,Alakuş M,taş m,İŞÇAN Y,TÜRKYILMAZ K,DURMUS M "Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification." , ss.111 - 115, 2013. |
| ISNAD | ÖNER, Veysi vd. "Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification". (2013), 111-115. |
| APA | ÖNER V, Alakuş M, taş m, İŞÇAN Y, TÜRKYILMAZ K, DURMUS M (2013). Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. Glokom Katarakt, 8(2), 111 - 115. |
| Chicago | ÖNER Veysi,Alakuş Mehmet Fuat,taş mehmet,İŞÇAN Yalçın,TÜRKYILMAZ Kemal,DURMUS MUSTAFA Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. Glokom Katarakt 8, no.2 (2013): 111 - 115. |
| MLA | ÖNER Veysi,Alakuş Mehmet Fuat,taş mehmet,İŞÇAN Yalçın,TÜRKYILMAZ Kemal,DURMUS MUSTAFA Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. Glokom Katarakt, vol.8, no.2, 2013, ss.111 - 115. |
| AMA | ÖNER V,Alakuş M,taş m,İŞÇAN Y,TÜRKYILMAZ K,DURMUS M Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. Glokom Katarakt. 2013; 8(2): 111 - 115. |
| Vancouver | ÖNER V,Alakuş M,taş m,İŞÇAN Y,TÜRKYILMAZ K,DURMUS M Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification. Glokom Katarakt. 2013; 8(2): 111 - 115. |
| IEEE | ÖNER V,Alakuş M,taş m,İŞÇAN Y,TÜRKYILMAZ K,DURMUS M "Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification." Glokom Katarakt, 8, ss.111 - 115, 2013. |
| ISNAD | ÖNER, Veysi vd. "Brimonidine-timolol versus dorzolamide- timolol for treatment of ıntraocular pressure spikes after phacoemulsification". Glokom Katarakt 8/2 (2013), 111-115. |
