Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder

Akbas, Halide; KARAMAN, Taha; DOĞANAVŞARGİL BAYSAL, Gülsüm Özge; metin, özmen; Cinemre, Buket; ZEHRA, Gökmen

Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder

Gökmen ZEHRA, (Kaçkar Devlet Hastanesi, Psikiyatri Bölümü, Rize, Türkiye)

Halide AKBAŞ, (Akdeniz Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Antalya, Türkiye)

Buket CİNEMRE, (Akdeniz Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Antalya, Türkiye)

Özmen METİN, (Akdeniz Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Antalya, Türkiye)

Taha KARAMAN, (Akdeniz Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Antalya, Türkiye)

Gülsüm Özge DOĞANAVŞARGİL BAYSAL (Akdeniz Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Antalya, Türkiye)

Türk Psikiyatri Dergisi

23 5

Yıl: 2013 Cilt: 24 Sayı: 1 Sayfa Aralığı: 7 - 16 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder

Öz:

Amaç: Son zamanlarda araştırmacılar bipolar bozuklukta (BB) serum homosistein (HS) düzeyi ve bilişsel işlevler, özellikle de yürütücü işlevler arasındaki ilişkileri araştırmışlardır. Ancak bu araştırmaların sonuçları tutarsızlıklar göstermektedir. Bu çalışmada amaç ötimik BB’li hastalarda serum HS, metiyonin, folat, vitamin B12 düzeylerinin kontrollerden farklı olup olmadığını ve BB’li hastalarda HS, metiyonin, folat ve vitamin B12 düzeyleriyle bilişsel işlevler ve işlevsellik arasında ilişki olup olmadığını araştırmaktır.Yöntem: Altmış ötimik BB I tanılı hasta ile yirmi sağlıklı kontrol İşlevselliğin Genel Değerlendirilmesi Ölçeği ve Wisconsin Kart Eşleme Testi, Sözel Bellek Süreçleri Testi, Stroop Testi, İz Sürme Testi A, İz Sürme Testi B ve İşaretleme Testi’ni içeren bir grup nöropsikolojik test ile değerlendirildi. HS, metiyonin, folat, vitamin B12 hasta ve kontrol grubundan kanlar alındıktan sonra topluca çalışıldı.Bulgular: Serum metiyonin düzeyi açısından gruplar arasında anlamlı fark bulundu. HS, folik asit ve vitamin B12 düzeyleri açısından gruplar arasında anlamlı fark bulunmadı. Lojistik regresyon analizinde serum metiyonin düzeyi BB için yordayıcı olarak bulundu. Serum HS düzeyi hastalık süresi, atak sayısı ve manik atak sayısı ile istatistiksel olarak anlamlı pozitif korelasyon gösterdi. HS, metiyonin, B12 ve folik asit düzeyleri ile bilişsel işlevler ve işlevsellik arasında anlamlı ilişki bulunmadı.Sonuç: Düşük serum metiyonin düzeyinin BB için yordayıcı olduğu saptandı; bu durum SAM sentezinin azalmasına ve dolayısıyla metilasyon reaksiyonlarının oluşmasında sorunlara neden olabilir. Tek karbon metabolizmasının BB’deki yerini araştırmak için ek çalışmalara gereksinim vardır.

Anahtar Kelime:

Konular: Mühendislik, Biyotıp Kadın Hastalıkları ve Doğum Genel ve Dahili Tıp Hematoloji

Bipolar bozuklukta serum Homosistein ve metiyonin düzeylerinin bilişsel işlevler ve işlevsellikle ilişkisi

Öz:

Objective: The relationship between homocysteine (HCY) levels and cognitive impairments, particularly executive functions in bipolar disorder (BD), has recently been investigated. However, conflicting results were reported. The aim of the present study is to investigate changes in serum HCY, methionine, vitamine B12 and levels in BD patients are relative to controls and to investigate the relationship between HCY, methionine, vitamin B12, and folate levels and clinical features, cognitive functions and psychosocial functioning in euthymic BD patients and controls. Methods: Sixty BD type I euthymic patients and twenty controls were assessed with Global Assessment of Functioning and a battery of neuropsy- chological tests including the Wisconsin card sorting test, the Rey’s auditory verbal learning test, the Cancellation test, Trail making test A, Trail making test B, and the Stroop test. HCY, vitamin B12, methionine and folate levels were measured together after collecting blood samples from both patient and controls. Results: Mean serum methionine concentration was different between groups. Low serum methionine was found to be a predictor of BD. However, a statistically significant difference was not detected between groups for mean serum values of HCY, folate, or vitamin B12. HCY levels showed a positive correlation with illness duration, the number of total episodes, and the number of manic episodes. A significant correlation was not found between HCY, methionine, folate, B12 levels with cognitive functions and functioning in the BD group. Conclusion: Low serum methionine was found to be a predictor of BD, a condition which can lead to a decrease in SAM synthesis and thus to a variety of complications in methylation reactions. Additional studies are needed to clarify the impact of single carbon metabolism on BD.

Anahtar Kelime:

Konular: Mühendislik, Biyotıp Kadın Hastalıkları ve Doğum Genel ve Dahili Tıp Hematoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ZEHRA G, Akbas H, Cinemre B, metin ö, KARAMAN T, DOĞANAVŞARGİL BAYSAL G (2013). Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. , 7 - 16.
Chicago	ZEHRA Gökmen,Akbas Halide,Cinemre Buket,metin özmen,KARAMAN Taha,DOĞANAVŞARGİL BAYSAL Gülsüm Özge Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. (2013): 7 - 16.
MLA	ZEHRA Gökmen,Akbas Halide,Cinemre Buket,metin özmen,KARAMAN Taha,DOĞANAVŞARGİL BAYSAL Gülsüm Özge Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. , 2013, ss.7 - 16.
AMA	ZEHRA G,Akbas H,Cinemre B,metin ö,KARAMAN T,DOĞANAVŞARGİL BAYSAL G Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. . 2013; 7 - 16.
Vancouver	ZEHRA G,Akbas H,Cinemre B,metin ö,KARAMAN T,DOĞANAVŞARGİL BAYSAL G Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. . 2013; 7 - 16.
IEEE	ZEHRA G,Akbas H,Cinemre B,metin ö,KARAMAN T,DOĞANAVŞARGİL BAYSAL G "Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder." , ss.7 - 16, 2013.
ISNAD	ZEHRA, Gökmen vd. "Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder". (2013), 7-16.

APA	ZEHRA G, Akbas H, Cinemre B, metin ö, KARAMAN T, DOĞANAVŞARGİL BAYSAL G (2013). Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. Türk Psikiyatri Dergisi, 24(1), 7 - 16.
Chicago	ZEHRA Gökmen,Akbas Halide,Cinemre Buket,metin özmen,KARAMAN Taha,DOĞANAVŞARGİL BAYSAL Gülsüm Özge Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. Türk Psikiyatri Dergisi 24, no.1 (2013): 7 - 16.
MLA	ZEHRA Gökmen,Akbas Halide,Cinemre Buket,metin özmen,KARAMAN Taha,DOĞANAVŞARGİL BAYSAL Gülsüm Özge Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. Türk Psikiyatri Dergisi, vol.24, no.1, 2013, ss.7 - 16.
AMA	ZEHRA G,Akbas H,Cinemre B,metin ö,KARAMAN T,DOĞANAVŞARGİL BAYSAL G Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. Türk Psikiyatri Dergisi. 2013; 24(1): 7 - 16.
Vancouver	ZEHRA G,Akbas H,Cinemre B,metin ö,KARAMAN T,DOĞANAVŞARGİL BAYSAL G Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder. Türk Psikiyatri Dergisi. 2013; 24(1): 7 - 16.
IEEE	ZEHRA G,Akbas H,Cinemre B,metin ö,KARAMAN T,DOĞANAVŞARGİL BAYSAL G "Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder." Türk Psikiyatri Dergisi, 24, ss.7 - 16, 2013.
ISNAD	ZEHRA, Gökmen vd. "Association of serum homocysteine and methionine levels with cognition and functioning in bipolar disorder". Türk Psikiyatri Dergisi 24/1 (2013), 7-16.