Yıl: 2013 Cilt: 13 Sayı: 5 Sayfa Aralığı: 465 - 470 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study

Öz:
Amaç: YKL-40, yeni bir yerel enflamasyon biyobelirteci, aterosklerotik plaklar içerisinde makrofajlar tarafından salınırlar. Koroner arter ektazisi (KAE) etyopatogenezisi kesin olarak ortaya konulmamış klinik bir antitedir. Bazı çalışmalar KAEnin aterosklerozdan daha yoğun ve lokalize enflamatuvar özelliklere sahip olabileceğini ortaya koydu. Bu çalışmanın amacı eş zamanlı olarak YKL-40 ve C-reaktif protein (CRP) düzeylerini izole KAEli hastalarda araştırmak ve normal koroner arterli (NKA) veya koroner arter hastalığı (KAH) olan hastalar ile karşılaştırmak. Yöntemler: Çalışmamız gözlemsel ve kesitsel bir düzene sahiptir. Kırk dokuz izole KAElı hasta (ort. yaş: 60±10 yıl) ve 30 yaş ve cinsiyet uyumlu NKAlı birey (ort. yaş: 58±12 yıl) ve KAHlı hasta (ort.yaş: 61±10 yıl) çalışmaya dahil edildi. YKL-40, CRP düzeyi ve KAE varlığı arasındaki ilişki araştırıldı. Tek değişkenli ve ardından çoklu lojistik regresyon analizi KAEyi öngörmede bağımsız değişkenlerin analizinde kullanıldı. Bulgular: Serum YKL-40 düzeyleri gruplar arasında anlamlı olarak farklıydı (NKA: 110±53 μg/L, KAE: 144±68 ve KAH: 180±117, p=0,005). KAH ve KAE grupları NKA grubuna göre belirgin daha yüksek YKL-40 düzeyine sahiptiler (p=0,004 ve p=0,015, sırasıyla). CRP üç grup arasında anlamlı olarak farklı değildi. Ek olarak, gruplar arasında yaş, cinsiyet, hipertansiyon, diyabet varlığı ve sigara içimi açısından da fark yoktu (p>0,05). Lojistik regresyon analizi yalnızca YKL-40 düzeyini KAEnin bağımsız belirleyicisi olarak ortaya koydu (OR: 1,010, 95% GA: 1,001-1,019, p=0,027). Sonuç: İzole KAEli hastalarda YKL-40 düzeyleri NKAlı hastalar ile karşılaştırıldığında anlamlı olarak yüksekti ve sadece YKL-40 KAEnin bağımsız belirleyicisi olarak saptandı. İnanıyoruz ki, daha ileri çalışmalar izole KAEli hastalarda YKL-40ın olası nedensel rolünü netleştirmede gereklidir
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

İzole koroner arter ektazili hastalarda artmış YKL-40 düzeyleri: Gözlemsel bir çalışma

Öz:
Objective: YKL-40, a new biomarker of localized inflammation, is secreted by macrophages within the atherosclerotic plaques. Coronary artery ectasia (CAE) is a clinical entity with unclear etiopathogenesis. Some studies have revealed that CAE may be a form of atherosclerosis that has more localized and intense inflammatory properties than atherosclerosis. The goal of this study was to investigate YKL-40 and C-reactive protein (CRP) levels in patients with isolated CAE compared to patients with normal coronary arteries (NCA) and coronary artery disease (CAD). Methods: Our study has an observational and cross-sectional design. Forty-nine patients with isolated CAE (mean age: 60±10 years), 30 age-and gender-matched control participants with NCA (30 patients, mean age: 58±12 years) and 30 patients with CAD (mean age: 61±10 years), were included in the study. The relationship between YKL-40, CRP levels and the presence of CAE was investigated. Univariate and multiple logistic regression analysis were used for analysis of independent variables to predict CAE. Results: Serum YKL-40 levels were significantly different among study groups (NCA: 110±53 μg/L, CAE: 144±68 and CAD: 180±117, p=0.005). CAD group and CAE group had significantly higher YKL-40 levels than NCA group (p=0.004 and p=0.015, respectively). CRP was not significantly dif- ferent between three groups. In addition, there were no any statistically significant differences, with respect to age, gender, the presence of hypertension or diabetes mellitus, and the smoking status (p>0.05). Logistic regression analysis revealed only YKL-40 level as the determinant of CAE (OR: 1.010, 95% CI: 1.001-1.019, p=0.027). Conclusion: YKL-40 levels in patients with isolated CAE compared to patients with NCA were found significantly high and only YKL-40 level was established as the determinant of CAE. We believe that further studies are needed to clarify the possible causative roles of YKL-40 in patients with isolated CAE.
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ERDOĞAN T, KOCAMAN S, ÇETİN M, Durakoglugil M, Kırbaş A, ÇANĞA A, YILMAZ A, DOĞAN S, çiçek y (2013). Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. , 465 - 470.
Chicago ERDOĞAN Turan,KOCAMAN Sinan Altan,ÇETİN Mustafa,Durakoglugil Murtaza Emre,Kırbaş Aynur,ÇANĞA Aytun,YILMAZ ADNAN,DOĞAN Sıtkı,çiçek yüksel gülen Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. (2013): 465 - 470.
MLA ERDOĞAN Turan,KOCAMAN Sinan Altan,ÇETİN Mustafa,Durakoglugil Murtaza Emre,Kırbaş Aynur,ÇANĞA Aytun,YILMAZ ADNAN,DOĞAN Sıtkı,çiçek yüksel gülen Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. , 2013, ss.465 - 470.
AMA ERDOĞAN T,KOCAMAN S,ÇETİN M,Durakoglugil M,Kırbaş A,ÇANĞA A,YILMAZ A,DOĞAN S,çiçek y Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. . 2013; 465 - 470.
Vancouver ERDOĞAN T,KOCAMAN S,ÇETİN M,Durakoglugil M,Kırbaş A,ÇANĞA A,YILMAZ A,DOĞAN S,çiçek y Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. . 2013; 465 - 470.
IEEE ERDOĞAN T,KOCAMAN S,ÇETİN M,Durakoglugil M,Kırbaş A,ÇANĞA A,YILMAZ A,DOĞAN S,çiçek y "Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study." , ss.465 - 470, 2013.
ISNAD ERDOĞAN, Turan vd. "Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study". (2013), 465-470.
APA ERDOĞAN T, KOCAMAN S, ÇETİN M, Durakoglugil M, Kırbaş A, ÇANĞA A, YILMAZ A, DOĞAN S, çiçek y (2013). Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi, 13(5), 465 - 470.
Chicago ERDOĞAN Turan,KOCAMAN Sinan Altan,ÇETİN Mustafa,Durakoglugil Murtaza Emre,Kırbaş Aynur,ÇANĞA Aytun,YILMAZ ADNAN,DOĞAN Sıtkı,çiçek yüksel gülen Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi 13, no.5 (2013): 465 - 470.
MLA ERDOĞAN Turan,KOCAMAN Sinan Altan,ÇETİN Mustafa,Durakoglugil Murtaza Emre,Kırbaş Aynur,ÇANĞA Aytun,YILMAZ ADNAN,DOĞAN Sıtkı,çiçek yüksel gülen Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi, vol.13, no.5, 2013, ss.465 - 470.
AMA ERDOĞAN T,KOCAMAN S,ÇETİN M,Durakoglugil M,Kırbaş A,ÇANĞA A,YILMAZ A,DOĞAN S,çiçek y Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(5): 465 - 470.
Vancouver ERDOĞAN T,KOCAMAN S,ÇETİN M,Durakoglugil M,Kırbaş A,ÇANĞA A,YILMAZ A,DOĞAN S,çiçek y Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study. Anadolu Kardiyoloji Dergisi. 2013; 13(5): 465 - 470.
IEEE ERDOĞAN T,KOCAMAN S,ÇETİN M,Durakoglugil M,Kırbaş A,ÇANĞA A,YILMAZ A,DOĞAN S,çiçek y "Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study." Anadolu Kardiyoloji Dergisi, 13, ss.465 - 470, 2013.
ISNAD ERDOĞAN, Turan vd. "Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study". Anadolu Kardiyoloji Dergisi 13/5 (2013), 465-470.