Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery

Ünal, Ertekin Utku; Durukan, Ahmet Baris; durukan, elif; kubat, emre; Yurdakök, Okan; Kocabeyoglu, Sinan Sabit; Özen, Anıl; Birincioğlu, Cemal Levent

Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery

Ertekin Utku ÜNAL, (Sağlık Bakanlığı, Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye)

Ahmet Barış DURUKAN, (Medicana International Ankara Hastanesi, Kalp ve Damar Cerrahisi Bölümü, Ankara, Türkiye)

Anıl ÖZEN, (Sağlık Bakanlığı, Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye)

Emre KUBAT, (Sağlık Bakanlığı, Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye)

Sinan Sabit KOCABEYOĞLU, (Sağlık Bakanlığı, Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye)

Okan YURDAKÖK, (Sağlık Bakanlığı, Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye)

Elif DURUKAN, (Başkent Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Ankara, Türkiye)

Cemal Levent BİRİNCİOĞLU (Sağlık Bakanlığı, Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye)

Türk Göğüs Kalp Damar Cerrahisi Dergisi

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Yıl: 2013 Cilt: 21 Sayı: 3 Sayfa Aralığı: 588 - 593 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery

Öz:

Amaç: Bu çalışmada yeni geliştirilen bir enflamatuvar parametre olan nötrofil/lenfosit oranının koroner arter bay- pas greft (KABG) cerrahisi sonrası erken dönem mortalite prediktörü olarak etkisi araştırıldı. Çalışma planı: Aralık 2011 - Nisan 2012 tarihleri arasında kliniğimizde izole KABG cerrahisi yapılan ardışık 210 hasta prospektif olarak incelendi. Hastaların başlangıç özellikleri ve ameliyat öncesi nötrofil/lenfosit oranları belirlendi. Ameliyat sonrası takip süresi 86.1±38.9 gün idi. Primer sonlanım noktası, tüm-nedenlere bağlı mortalite olarak belirlendi. Bulgul ar: Dört hastada ameliyat sonrası ilk 30 günde olmak üzere, toplam sekiz hastada (%3.8) mortalite görüldü. Tek değişkenli analizlerde ameliyat öncesi nötrofil/lenfosit oranı, mortalite gelişen ve gelişmeyen gruplar arasında anlamlı derecede farklı olarak saptandı (p= 0.037). Alıcı işlem karakteristikleri (ROC) eğrisinde nötrofil/lenfosit oranı için eşik değeri 2.81 olarak belir- lendi (AUC= 0.72, duyarlılık: %75, özgüllük: %67). İki grup arasında anlamlı farka sahip olan değişkenler ile yapılan lojistik regresyon analizinde ise, nötrofil/lenfosit oranı için eşik değerinin üzerinde olması mortalite için bağımsız bir prediktör olarak saptandı (OR 6.47, %95 CI 1.18-35.38, p= 0.031). Sonuç: Kolay bir şekilde hesaplanabilen nötrofil/lenfosit oranı KABG cerrahisi sonrası erken dönem mortaliteyi öngörmede bağımsız bir faktör olarak kullanılabilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi Cerrahi

Koroner arter baypas greft cerrahisi sonrası mortalite prediktörü olarak nötrofil/lenfosit oranı

Öz:

Background: In this study, we aimed to investigate the newly introduced inflammatory biomarker, neutrophil/ lymphocyte ratio, as a mortality predictor following coronary artery bypass graft (CABG) surgery. Methods: Between December 2011 and April 2012, 210 consecutive patients who underwent isolated CABG surgery in our clinic were prospectively analyzed. The baseline characteristics of the patients and preoperative neutrophil/ lymphocyte ratio were determined. The postoperative follow-up was 86.1±38.9 days. The primary endpoint was all-cause mortality. Results: Eight patients (3.8%) died of whom four deaths occurred during the first 30 days of follow-up. Univariate analyses revealed a significant difference in the preoperative neutrophil/lymphocyte ratio between the groups in which mortality was seen and the group in which no mortality was observed (p=0.037). The Receiver operating characteristic (ROC) curve showed a threshold value of 2.81 for neutrophil/lymphocyte ratio (AUC=0.72, sensitivity: 75%, specificity: 67%). Logistic regression analysis of the variables with significant differences between two groups revealed that the neutrophil/lymphocyte ratio over its threshold value was an independent predictor for mortality (OR 6.47, 95% CI 1.18-35.38, p=0.031). Conclusion: Neutrophil/lymphocyte ratio, which can be easily calculated, can be used as an independent factor in predicting early mortality following CABG surgery.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ünal E, Durukan A, Özen A, kubat e, Kocabeyoglu S, Yurdakök O, durukan e, Birincioğlu C (2013). Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. , 588 - 593.
Chicago	Ünal Ertekin Utku,Durukan Ahmet Baris,Özen Anıl,kubat emre,Kocabeyoglu Sinan Sabit,Yurdakök Okan,durukan elif,Birincioğlu Cemal Levent Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. (2013): 588 - 593.
MLA	Ünal Ertekin Utku,Durukan Ahmet Baris,Özen Anıl,kubat emre,Kocabeyoglu Sinan Sabit,Yurdakök Okan,durukan elif,Birincioğlu Cemal Levent Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. , 2013, ss.588 - 593.
AMA	Ünal E,Durukan A,Özen A,kubat e,Kocabeyoglu S,Yurdakök O,durukan e,Birincioğlu C Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. . 2013; 588 - 593.
Vancouver	Ünal E,Durukan A,Özen A,kubat e,Kocabeyoglu S,Yurdakök O,durukan e,Birincioğlu C Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. . 2013; 588 - 593.
IEEE	Ünal E,Durukan A,Özen A,kubat e,Kocabeyoglu S,Yurdakök O,durukan e,Birincioğlu C "Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery." , ss.588 - 593, 2013.
ISNAD	Ünal, Ertekin Utku vd. "Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery". (2013), 588-593.

APA	Ünal E, Durukan A, Özen A, kubat e, Kocabeyoglu S, Yurdakök O, durukan e, Birincioğlu C (2013). Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 21(3), 588 - 593.
Chicago	Ünal Ertekin Utku,Durukan Ahmet Baris,Özen Anıl,kubat emre,Kocabeyoglu Sinan Sabit,Yurdakök Okan,durukan elif,Birincioğlu Cemal Levent Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. Türk Göğüs Kalp Damar Cerrahisi Dergisi 21, no.3 (2013): 588 - 593.
MLA	Ünal Ertekin Utku,Durukan Ahmet Baris,Özen Anıl,kubat emre,Kocabeyoglu Sinan Sabit,Yurdakök Okan,durukan elif,Birincioğlu Cemal Levent Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. Türk Göğüs Kalp Damar Cerrahisi Dergisi, vol.21, no.3, 2013, ss.588 - 593.
AMA	Ünal E,Durukan A,Özen A,kubat e,Kocabeyoglu S,Yurdakök O,durukan e,Birincioğlu C Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2013; 21(3): 588 - 593.
Vancouver	Ünal E,Durukan A,Özen A,kubat e,Kocabeyoglu S,Yurdakök O,durukan e,Birincioğlu C Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2013; 21(3): 588 - 593.
IEEE	Ünal E,Durukan A,Özen A,kubat e,Kocabeyoglu S,Yurdakök O,durukan e,Birincioğlu C "Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery." Türk Göğüs Kalp Damar Cerrahisi Dergisi, 21, ss.588 - 593, 2013.
ISNAD	Ünal, Ertekin Utku vd. "Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery". Türk Göğüs Kalp Damar Cerrahisi Dergisi 21/3 (2013), 588-593.