Yıl: 2013 Cilt: 41 Sayı: 4 Sayfa Aralığı: 284 - 289 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes

Öz:
Amaç: Enflamasyonun akut koroner sendrom (AKS) oluşumunda ve ilerlemesinde önemli bir rol oynadığı bilinmektedir. Beyaz kan hücresi ve alt tipleri AKS’li hastalarda enflamasyonun bir göstergesidir. Bu çalışmada, beyaz kan hücresi ve alt tiplerinin <45 yaş genç hastalarda AKS ile ilişkisinin değerlendirilmesi amaçlandı. Çalışma planı: Göğüs ağrısı şikâyetiyle acil servise başvuran ST yükselmesi olmayan AKS’li (STYz-AKS) 84 genç (<45 yıl) hastanın (40 ST yükselmesiz miyokart enfarktüslü [STYzME], 44 kararsız anjina pektoris) ve 40 kişilik kontrol grubunun beyaz kan hücresi ve alt tipleri olan nötrofil ve lenfosit oranları geriye dönük olarak incelendi. Bulgular: STYz-AKS’li hastalarda hipertansiyon, diabetes mellitus, sigara kullanımı ve aile öyküsü anlamlı olarak daha yüksekti. Bu grupta ayrıca LDL seviyeleri anlamlı olarak yüksek ve HDL seviyeleri anlamlı olarak düşük bulundu (p=0.041 ve p=0.009). Gruplar arasında lenfosit oranları anlamlı olarak farklıydı (p=0.048). Tüm gruplar arasında ve STYzME’li ile kararsız anjina pektorisli gruplar arasında N/L oranı anlamlı olarak farklı bulundu (p<0.001 ve p=0.041). Ayrıca, çok değişkenli doğrusal regresyon analizinde hipertansiyonun, nötrofil yüzdesinin ve N/L oranının STYz-AKS için bağımsız öngördürücüler olduğu gösterildi (sırasıyla, beta=0.251, %95 GA=0.002- 0.523, p=0.048; beta=0.561, %95 GA=0.008-0.137, p=0.028 ve beta=0.260, %95 GA=0.042-0.438, p=0.018). Sonuç: N/L oranı, STYz-AKS’li genç hastalarda kontrol grubundan daha yüksek bulunmuştur. Genç STYz-AKS’li hastalarda enflamasyonun beyaz kan hücreleri ve alt tipleri ile değerlendirilmesi daha da önemli rol oynayabilir.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Genel ve Dahili Tıp Hematoloji

Akut koroner sendromlu genç hastalarda nötrofil lenfosit oranının değerlendirilmesi

Öz:
Objectives: It is well known that inflammation plays a key role in both initiation and propagation of acute coronary syndrome (ACS). White blood cell (WBC) and its subtypes are an indicator of inflammation in patients with ACS. We aimed to evaluate the WBC and its subtypes in patients aged <45 year with acute coronary syndromes. Study design: We retrospectively analyzed WBC and its subtypes (including neutrophil and lymphocyte) in 84 patients (<45 year) who were admitted to the emergency department for chest pain suggestive of ACS (44 unstable angina pectoris, 40 non-ST-segment elevation myocardial infarction [NSTEMI]), and 40 healthy controls. Results: Hypertension, diabetes mellitus, smoking, and family history were significantly higher in NSTE-ACS patients. Also, LDL levels was significantly higher and HDL levels was significantly lower in NSTE-ACS patients (p=0.041 and p=0.009). The difference in percent of lymphocytes between the groups was significant (p=0.048). N/L ratio was significantly different between all groups and between the NSTEMI and USAP (p<0.001 and p=0.041). Our results demonstrated that hypertension, percent of neutrophils, and N/L ratio was a significant independent predictor of NSTE-ACS (Beta=0.251, 95% CI=0.002-0.523, p=0.048; beta=0.561, 95% CI=0.008-0.137, p=0.028 and beta=0.260, 95% CI=0.042-0.438, p=0.018, respectively). Conclusion: N/L was found to be elevated in young patients with NSTE-ACS compared with control group. The inflammation assessed using WBC and its subtypes may be more important in young NSTE-ACS patients.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Genel ve Dahili Tıp Hematoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Öztürk S, ERDEM A, ÖZLÜ M, Ayhan S, ERDEM K, ÖZYAŞAR M, ASLANTAŞ Y, YAZICI M (2013). Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. , 284 - 289.
Chicago Öztürk Serkan,ERDEM Alim,ÖZLÜ Mehmet Fatih,Ayhan Selim,ERDEM Kemalettin,ÖZYAŞAR Mehmet,ASLANTAŞ Yusuf,YAZICI Mehmet Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. (2013): 284 - 289.
MLA Öztürk Serkan,ERDEM Alim,ÖZLÜ Mehmet Fatih,Ayhan Selim,ERDEM Kemalettin,ÖZYAŞAR Mehmet,ASLANTAŞ Yusuf,YAZICI Mehmet Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. , 2013, ss.284 - 289.
AMA Öztürk S,ERDEM A,ÖZLÜ M,Ayhan S,ERDEM K,ÖZYAŞAR M,ASLANTAŞ Y,YAZICI M Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. . 2013; 284 - 289.
Vancouver Öztürk S,ERDEM A,ÖZLÜ M,Ayhan S,ERDEM K,ÖZYAŞAR M,ASLANTAŞ Y,YAZICI M Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. . 2013; 284 - 289.
IEEE Öztürk S,ERDEM A,ÖZLÜ M,Ayhan S,ERDEM K,ÖZYAŞAR M,ASLANTAŞ Y,YAZICI M "Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes." , ss.284 - 289, 2013.
ISNAD Öztürk, Serkan vd. "Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes". (2013), 284-289.
APA Öztürk S, ERDEM A, ÖZLÜ M, Ayhan S, ERDEM K, ÖZYAŞAR M, ASLANTAŞ Y, YAZICI M (2013). Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. Türk Kardiyoloji Derneği Arşivi, 41(4), 284 - 289.
Chicago Öztürk Serkan,ERDEM Alim,ÖZLÜ Mehmet Fatih,Ayhan Selim,ERDEM Kemalettin,ÖZYAŞAR Mehmet,ASLANTAŞ Yusuf,YAZICI Mehmet Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. Türk Kardiyoloji Derneği Arşivi 41, no.4 (2013): 284 - 289.
MLA Öztürk Serkan,ERDEM Alim,ÖZLÜ Mehmet Fatih,Ayhan Selim,ERDEM Kemalettin,ÖZYAŞAR Mehmet,ASLANTAŞ Yusuf,YAZICI Mehmet Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. Türk Kardiyoloji Derneği Arşivi, vol.41, no.4, 2013, ss.284 - 289.
AMA Öztürk S,ERDEM A,ÖZLÜ M,Ayhan S,ERDEM K,ÖZYAŞAR M,ASLANTAŞ Y,YAZICI M Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. Türk Kardiyoloji Derneği Arşivi. 2013; 41(4): 284 - 289.
Vancouver Öztürk S,ERDEM A,ÖZLÜ M,Ayhan S,ERDEM K,ÖZYAŞAR M,ASLANTAŞ Y,YAZICI M Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes. Türk Kardiyoloji Derneği Arşivi. 2013; 41(4): 284 - 289.
IEEE Öztürk S,ERDEM A,ÖZLÜ M,Ayhan S,ERDEM K,ÖZYAŞAR M,ASLANTAŞ Y,YAZICI M "Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes." Türk Kardiyoloji Derneği Arşivi, 41, ss.284 - 289, 2013.
ISNAD Öztürk, Serkan vd. "Assessment of the neutrophil to lymphocyte ratio in young patients with acute coronary syndromes". Türk Kardiyoloji Derneği Arşivi 41/4 (2013), 284-289.