Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi

TANER, Ali

Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi

Ali TANER (Kocatepe Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Afyon, Türkiye)

Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi

2 0

Yıl: 2013 Cilt: 14 Sayı: 3 Sayfa Aralığı: 129 - 134 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi

Öz:

Amaç: Stabil koroner arter hastalığında (KAH) hipertansiyo- nun (HT) inflamatuar sürece ilave katkısının olup olmadığını araştırmaktır. Gereç ve Yöntem: Hastalar üç gruba ayrıldı; Grup I sadece KAH olan, Grup II ise KAHa ilaveten HTsi olan hastalardan oluşturuldu. Kontrol grubu benzer yaş grubunda sağlıklı gönüllülerden oluşturuldu. hs-CRP, IL-1β, IL-6, IL-10 ve TNF- αnın düzeyleri ölçüldü. Bulgular: hs-CRP değerleri karşılaştırıldığında, KAH grubun- da hs-CRP değerinin anlamlı derecede artmış olduğu bulun- du (KAH: 1.4±0.8 mg/L, Kontrol: 0.7±0.6 mg/L, p <0.01). KAHa HTnin eşlik ettiği grup ile kontrol grubu karşılaştırıl- dığında KAH+HT grubunda hs-CRP değerinin anlamlı dere- cede artmış olduğu saptandı (KAH+HT:1.9±1.2 mg/L, Kont- rol: 0.7±0.6 mg/L, p <0.001). KAH grubu ile kontrol grubu arasındaki TNF-α ve IL-1β değerleri karşılaştırıldığında KAH grubunda TNF-α değerinin anlamlı derecede artmış olduğu bulundu. Bununla birlikte, IL-10 değerleri karşılaştırıldığında gruplar arasında fark olmadığı belirlendi. Sonuç: Stabil dahi olsa, KAH hastalarında kontrol grubuna göre artmış inflamatuar yanıt saptandı. HTnin inflamatuar süreç üzerine additif etkisi gösterilemedi.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Hematoloji Gastroenteroloji ve Hepatoloji Pediatri

Additive effect of hypertension to ınflammation reaction in coronary artery patients

Öz:

Objective: Investigation about an additional contribution of hypertension (HT) to inflammatory process in stable coronary artery disease (CAD). Material and Methods: Patients were divided into three groups . Group I only with CAD, Group II generated with patients with HT in addition to the CAD. The control group was created with healthy volunteers of similar age group. hs-CRP, IL-1β, IL-6, IL-10 and TNF-α levels were measured. Results: When hs-CRP levels are compared the value of hs- CRP in patients with CAD was found to be significantly increased (HR: 1.4 ± 0.8 mg / L , control: 0.7 ± 0.6 mg / L , p <0.01). When the patients with HT in addition to the CAD and the patients in control group are compared , the value of hs-CRP were significantly increased in the group of CAD+HT (CAD+HT: 1.9 ± 1.2 mg / L, Control: 0.7 ± 0.6 mg /L, p <0.001 ). When the TNF-α and IL-1β levels between the CAD group and the control group are compared TNF-α and IL-1β levels in patients with CAD was found to have significantly increased TNF-α value. However, IL-10 levels were not different between groups. Conclusion: Even if it is stable, the inflammatory response in patients with CAD was significantly higher than that in the control group. HT demonstrated an additive effect on the inflammatory process.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Hematoloji Gastroenteroloji ve Hepatoloji Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TANER A (2013). Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. , 129 - 134.
Chicago	TANER Ali Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. (2013): 129 - 134.
MLA	TANER Ali Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. , 2013, ss.129 - 134.
AMA	TANER A Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. . 2013; 129 - 134.
Vancouver	TANER A Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. . 2013; 129 - 134.
IEEE	TANER A "Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi." , ss.129 - 134, 2013.
ISNAD	TANER, Ali. "Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi". (2013), 129-134.

APA	TANER A (2013). Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, 14(3), 129 - 134.
Chicago	TANER Ali Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi 14, no.3 (2013): 129 - 134.
MLA	TANER Ali Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, vol.14, no.3, 2013, ss.129 - 134.
AMA	TANER A Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi. 2013; 14(3): 129 - 134.
Vancouver	TANER A Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi. 2013; 14(3): 129 - 134.
IEEE	TANER A "Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi." Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, 14, ss.129 - 134, 2013.
ISNAD	TANER, Ali. "Koroner arter hastalarında hipertansiyonun inflamatuar reaksiyona additif etkisi". Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi 14/3 (2013), 129-134.