Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients

Amaç: Kronik myeloid lösemi (KML) tanısı olan hastalarda tedavi ve takip kriterleri son 10 yılda çok ciddi değişimlere uğramıştır. Özellikle NCCN ve ELN kılavuzlarının yayınlanması ve düzenli olarak güncellenmesiyle hastaların daha yakın takibi mümkün olmuştur. Ancak güncel uygulamaları değerlendirebilmek için kayıt ve retrospektif analizlere ihtiyaç vardır. Gereç ve Yöntemler: Bu çalışmada, ülkemizde 12 merkezin katılımıyla KML tanısıyla izlenen 1133 hastanın demografik özellikleri, hastalık durumları, yanıt, direnç ve ikinci kuşak tirozin kinaz inhibitör kullanımları analiz edilmiştir. Bulgular: Hasta grubumuzda, yanıt oranlarının litaretüre göre daha yüksek olduğu, moleküler yanıt değerlendirmenin tüm merkezlerde mümkün olmadığı saptanmıştır. Sonuç: KML hastalarının bakım kalitesinin arttırılması için moleküler teknik kullanımının arttırılması ve daha yaygın kayıt sistemine ihtiyaç vardır.

Anahtar Kelime:

Konular: Hematoloji

Türk kronik myeloid lösemi çalışması: KML hastalarının geriye dönük kesitsel incelenmesi

Öz:

Objective: here have been tremendous changes in treatment and follow-up of patients with chronic myeloid leukemia (CML) in the last decade. Especially, regular publication and updating of NCCN and ELN guidelines have provided enermous rationale and base for close monitorization of patients with CML. But, it is stil needed to have registry results retrospectively to evaluate daily CML practices. Materials and Methods: In this article, we have evaluated 1133 patients results with CML in terms of demographical features, disease status, response, resistance and use of second-generation TKIs. Results: The response rate has been found relatively high in comparison with previously published articles, and we detected that there was a lack of appropriate and adequate molecular response assessment. Conclusion: We concluded that we need to improve registry systems and increase the availability of molecular response assessment to provide high-quality patient care.

Anahtar Kelime:

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1.Corm S, Roche L, Micol JB, Coiteux V, Bossard N, Nicolini FE, Iwaz J, Preudhomme C, Roche-Lestienne C, Facon T, Remontet L. Changes in the dynamic of the excess mortality rate in chronic phase-chronic myeloid leukemia over 1990- 2007: a population study. Blood 2011;118:4331-4337.
2.Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990;247:824-830.
3.Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990;247:1079-1082.
4.Rowley JD. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973;243:290-293.
5.Sokal JE, Baccarani M, Russo D, Tura S. Staging and prognosis in chronic myelogenous leukemia. Semin Hematol 1988;25:49-61.
6.Kurzrock G, Gutterman J, Talpaz M. The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 1988;319:990-998.
7.Saydam G, Haznedaroglu IC, Temiz Y, Soysal T, Sucak G, Tombuloglu M, Ozdogu H, Yavuz S, Altintas A, Ozet G, Gulbas Z, Ferhanoglu B, Ilhan O. Retrospective evaluation of patients treated with dasatinib for Philadelphia positive leukemias: Turkish experience of 16 months. UHOD 2009;19:195-204.
8.OBrien SG, Guilhot F Larson RA, Gathmann I, Baccarani M, Cervantes F Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, Lechner K, Nielsen JL, Rousselot P, Reiffers J, Saglio G, Shepherd J, Simonsson B, Gratwohl A, Goldman JM, Kantarjian H, Taylor K, Verhoef G, Bolton AE, Capdeville R, Druker BJ; IRIS Investigators. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994-1004.
9.Druker BJ, Guilhot F OBrien SG, Gathmann I, Kantarjian H, Gattermann N, Deininger MW, Silver RT, Goldman JM, Stone RM, Cervantes F Hochhaus A, Powell BL, Gabrilove JL, Rousselot P, Reiffers J, Cornelissen JJ, Hughes T, Agis H, Fischer T, Verhoef G, Shepherd J, Saglio G, Gratwohl A, Nielsen JL, Radich JP, Simonsson B, Taylor K, Baccarani M, So C, Letvak L, Larson RA; IRIS Investigators. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408-2417.
10.Roy L, Guilhot J, Krahnke T, Guerci-Bresler A, Druker BJ, Larson RA, OBrien S, So C, Massimini G, Guilhot F Survival advantage from imatinib compared with combination interferon-alpha plus cytarabine in chronic-phase chronic myelogenous leukemia: historical comparison between two phase 3 trials. Blood 2006;108:1478-1484.
11.Bittencourt H, Funke V, Fogliatto L, Magalhães S, Setubal D, Paz A, Macedo AV, Ruiz J, Azambuja AP, Silla L, Clementino N, Pasquini R. Imatinib mesylate versus allogeneic BMT for patients with chronic myeloid leukemia in first chronic phase. Bone Marrow Transplant 2008;42:597-600.
12.de Lavallade H, Apperley JF Khorashad JS, Milojkovic D, Reid AG, Bua M, Szydlo R, Olavarria E, Kaeda J, Goldman JM, Marin D. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J Clin Oncol 2008;26:3358-3363.
13.Lucas CM, Wang L, Austin GM, Knight K, Watmough SJ, Shwe KH, Dasgupta R, Butt NM, Galvani D, Hoyle CF Seale JR, Clark RE. A population study of imatinib in chronic myeloid leukemia demonstrates lower efficacy than in clinical trials. Leukemia 2008;22:1963-1966.
14.Hehlmann R, Hocchaus A, Baccarani M. Chronic myeloid leukemia. Lancet 2007;370:342-350.
15.Rohrbacher M, Hasford J. Epidemiology of chronic myeloid leukemia. Best Pract Res Clin Haematol 2009;22:295-302.
16.Kizaki M, Okamoto S, Tauchi T, Tanaka H, Tanimoto M, Inokuchi K, Murayama T, Saburi Y, Hino M, Tsudo M, Shimomura T, Isobe Y; TARGET Investigators. Current and future perspectives on the TARGET system: the registration system for Glivec established by JSH. Int J Hematol 2008;88:409-417.
17.Tauchi T, Kizaki M, Okamoto S, Tanaka H, Tanimoto M, Inokuchi K, Murayama T, Saburi Y, Hino M, Tsudo M, Shimomura T, Isobe Y, Oshimi K, Dan K, Ohyashiki K, Ikeda Y; TARGET Investigators. Seven-year follow-up of patients receiving imatinib for the treatment of newly diagnosed chronic myelogenous leukemia by the TARGET system. Leuk Res 2011;35:585-590.
18.Björkholm M, Ohm L, Eloranta S, Derolf A, Hultcrantz M, Sjöberg J, Andersson T, Höglund M, Richter J, Landgren O, Kristinsson SY, Dickman PW. Success story of targeted therapy in chronic myeloid leukemia: a population-based study of patients diagnosed in Sweden from 1973 to 2008. J Clin Oncol 2011;29:2514-2520.
19.Faber E, Mužík J, Koza V, Demeková E, Voglová J, Demitrovi ová L, Chrudej J, Markuljak I, Cmunt E, Kozák T, Tóthová E, Jaroová M, Duek L, Indrák K. Treatment of consecutive patients with chronic myeloid leukemia in the cooperating centres from the Czech Republic and the whole of Slovakia after 2000--a report from the population-based CAMELIA Registry. Eur J Haematol 2011;87:157-168.
20.Hasford J, Baccarani M, Hoffmann V, Guilhot J, Saussele S, Rosti G, Guilhot F Porkka K, Ossenkoppele G, Lindoerfer D, Simonsson B, Pfirrmann M, Hehlmann R. Predicting complete cytogenetic response and subsequent progression- free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood 2011;118:686-692.

APA	Sahin F, SAYDAM G, Cömert M, UZ B, YAVUZ A, TURAN E, YÖNAL HİNDİLERDEN İ, atay m, KELTİKLİ E, TURGUT M, PEHLİVAN M, AKAY O, GURKAN E, Paydas S, kahraman s, DEMİRKAN F, KIRKIZLAR O, AKPINAR S, PAMUK G, DEMİR A, ÖZBAŞ H, Sönmez M, GÜLTÜRK M, Salihoglu A, Eşkazan A, AR M, HAYDAROĞLU ŞAHİN H, Öngören Ş, BAŞLAR Z, AYDIN y, YENERE M, Tuzuner N, FERHANOĞLU A, HAZNEDAROĞLU C, ilhan o, Soysal T (2013). Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. , 351 - 358.
Chicago	Sahin Fahri,SAYDAM Güray,Cömert Melda,UZ Burak,YAVUZ AKIF SELIM,TURAN Esra,YÖNAL HİNDİLERDEN İpek,atay memiş hilmi,KELTİKLİ Engin,TURGUT Mehmet,PEHLİVAN MUSTAFA,AKAY Olga Meltem,GURKAN EMEL,Paydas Semra,kahraman selda,DEMİRKAN Fatih,KIRKIZLAR Onur,AKPINAR SEVAL,PAMUK Gülsüm Emel,DEMİR Ahmet Muzaffer,ÖZBAŞ Hasan Mücahit,Sönmez Mehmet Emin,GÜLTÜRK Mine,Salihoglu Ayse,Eşkazan Ahmet Emre,AR Muhlis Cem,HAYDAROĞLU ŞAHİN HANDAN,Öngören Şeniz,BAŞLAR ZAFER,AYDIN yıldız,YENERE Mustafa Nuri,Tuzuner Nukhet,FERHANOĞLU AHMET BURHAN,HAZNEDAROĞLU C. İbrahim,ilhan osman,Soysal Teoman Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. (2013): 351 - 358.
MLA	Sahin Fahri,SAYDAM Güray,Cömert Melda,UZ Burak,YAVUZ AKIF SELIM,TURAN Esra,YÖNAL HİNDİLERDEN İpek,atay memiş hilmi,KELTİKLİ Engin,TURGUT Mehmet,PEHLİVAN MUSTAFA,AKAY Olga Meltem,GURKAN EMEL,Paydas Semra,kahraman selda,DEMİRKAN Fatih,KIRKIZLAR Onur,AKPINAR SEVAL,PAMUK Gülsüm Emel,DEMİR Ahmet Muzaffer,ÖZBAŞ Hasan Mücahit,Sönmez Mehmet Emin,GÜLTÜRK Mine,Salihoglu Ayse,Eşkazan Ahmet Emre,AR Muhlis Cem,HAYDAROĞLU ŞAHİN HANDAN,Öngören Şeniz,BAŞLAR ZAFER,AYDIN yıldız,YENERE Mustafa Nuri,Tuzuner Nukhet,FERHANOĞLU AHMET BURHAN,HAZNEDAROĞLU C. İbrahim,ilhan osman,Soysal Teoman Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. , 2013, ss.351 - 358.
AMA	Sahin F,SAYDAM G,Cömert M,UZ B,YAVUZ A,TURAN E,YÖNAL HİNDİLERDEN İ,atay m,KELTİKLİ E,TURGUT M,PEHLİVAN M,AKAY O,GURKAN E,Paydas S,kahraman s,DEMİRKAN F,KIRKIZLAR O,AKPINAR S,PAMUK G,DEMİR A,ÖZBAŞ H,Sönmez M,GÜLTÜRK M,Salihoglu A,Eşkazan A,AR M,HAYDAROĞLU ŞAHİN H,Öngören Ş,BAŞLAR Z,AYDIN y,YENERE M,Tuzuner N,FERHANOĞLU A,HAZNEDAROĞLU C,ilhan o,Soysal T Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. . 2013; 351 - 358.
Vancouver	Sahin F,SAYDAM G,Cömert M,UZ B,YAVUZ A,TURAN E,YÖNAL HİNDİLERDEN İ,atay m,KELTİKLİ E,TURGUT M,PEHLİVAN M,AKAY O,GURKAN E,Paydas S,kahraman s,DEMİRKAN F,KIRKIZLAR O,AKPINAR S,PAMUK G,DEMİR A,ÖZBAŞ H,Sönmez M,GÜLTÜRK M,Salihoglu A,Eşkazan A,AR M,HAYDAROĞLU ŞAHİN H,Öngören Ş,BAŞLAR Z,AYDIN y,YENERE M,Tuzuner N,FERHANOĞLU A,HAZNEDAROĞLU C,ilhan o,Soysal T Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. . 2013; 351 - 358.
IEEE	Sahin F,SAYDAM G,Cömert M,UZ B,YAVUZ A,TURAN E,YÖNAL HİNDİLERDEN İ,atay m,KELTİKLİ E,TURGUT M,PEHLİVAN M,AKAY O,GURKAN E,Paydas S,kahraman s,DEMİRKAN F,KIRKIZLAR O,AKPINAR S,PAMUK G,DEMİR A,ÖZBAŞ H,Sönmez M,GÜLTÜRK M,Salihoglu A,Eşkazan A,AR M,HAYDAROĞLU ŞAHİN H,Öngören Ş,BAŞLAR Z,AYDIN y,YENERE M,Tuzuner N,FERHANOĞLU A,HAZNEDAROĞLU C,ilhan o,Soysal T "Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients." , ss.351 - 358, 2013.
ISNAD	Sahin, Fahri vd. "Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients". (2013), 351-358.

APA	Sahin F, SAYDAM G, Cömert M, UZ B, YAVUZ A, TURAN E, YÖNAL HİNDİLERDEN İ, atay m, KELTİKLİ E, TURGUT M, PEHLİVAN M, AKAY O, GURKAN E, Paydas S, kahraman s, DEMİRKAN F, KIRKIZLAR O, AKPINAR S, PAMUK G, DEMİR A, ÖZBAŞ H, Sönmez M, GÜLTÜRK M, Salihoglu A, Eşkazan A, AR M, HAYDAROĞLU ŞAHİN H, Öngören Ş, BAŞLAR Z, AYDIN y, YENERE M, Tuzuner N, FERHANOĞLU A, HAZNEDAROĞLU C, ilhan o, Soysal T (2013). Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. Turkish Journal of Hematology, 30(4), 351 - 358.
Chicago	Sahin Fahri,SAYDAM Güray,Cömert Melda,UZ Burak,YAVUZ AKIF SELIM,TURAN Esra,YÖNAL HİNDİLERDEN İpek,atay memiş hilmi,KELTİKLİ Engin,TURGUT Mehmet,PEHLİVAN MUSTAFA,AKAY Olga Meltem,GURKAN EMEL,Paydas Semra,kahraman selda,DEMİRKAN Fatih,KIRKIZLAR Onur,AKPINAR SEVAL,PAMUK Gülsüm Emel,DEMİR Ahmet Muzaffer,ÖZBAŞ Hasan Mücahit,Sönmez Mehmet Emin,GÜLTÜRK Mine,Salihoglu Ayse,Eşkazan Ahmet Emre,AR Muhlis Cem,HAYDAROĞLU ŞAHİN HANDAN,Öngören Şeniz,BAŞLAR ZAFER,AYDIN yıldız,YENERE Mustafa Nuri,Tuzuner Nukhet,FERHANOĞLU AHMET BURHAN,HAZNEDAROĞLU C. İbrahim,ilhan osman,Soysal Teoman Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. Turkish Journal of Hematology 30, no.4 (2013): 351 - 358.
MLA	Sahin Fahri,SAYDAM Güray,Cömert Melda,UZ Burak,YAVUZ AKIF SELIM,TURAN Esra,YÖNAL HİNDİLERDEN İpek,atay memiş hilmi,KELTİKLİ Engin,TURGUT Mehmet,PEHLİVAN MUSTAFA,AKAY Olga Meltem,GURKAN EMEL,Paydas Semra,kahraman selda,DEMİRKAN Fatih,KIRKIZLAR Onur,AKPINAR SEVAL,PAMUK Gülsüm Emel,DEMİR Ahmet Muzaffer,ÖZBAŞ Hasan Mücahit,Sönmez Mehmet Emin,GÜLTÜRK Mine,Salihoglu Ayse,Eşkazan Ahmet Emre,AR Muhlis Cem,HAYDAROĞLU ŞAHİN HANDAN,Öngören Şeniz,BAŞLAR ZAFER,AYDIN yıldız,YENERE Mustafa Nuri,Tuzuner Nukhet,FERHANOĞLU AHMET BURHAN,HAZNEDAROĞLU C. İbrahim,ilhan osman,Soysal Teoman Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. Turkish Journal of Hematology, vol.30, no.4, 2013, ss.351 - 358.
AMA	Sahin F,SAYDAM G,Cömert M,UZ B,YAVUZ A,TURAN E,YÖNAL HİNDİLERDEN İ,atay m,KELTİKLİ E,TURGUT M,PEHLİVAN M,AKAY O,GURKAN E,Paydas S,kahraman s,DEMİRKAN F,KIRKIZLAR O,AKPINAR S,PAMUK G,DEMİR A,ÖZBAŞ H,Sönmez M,GÜLTÜRK M,Salihoglu A,Eşkazan A,AR M,HAYDAROĞLU ŞAHİN H,Öngören Ş,BAŞLAR Z,AYDIN y,YENERE M,Tuzuner N,FERHANOĞLU A,HAZNEDAROĞLU C,ilhan o,Soysal T Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. Turkish Journal of Hematology. 2013; 30(4): 351 - 358.
Vancouver	Sahin F,SAYDAM G,Cömert M,UZ B,YAVUZ A,TURAN E,YÖNAL HİNDİLERDEN İ,atay m,KELTİKLİ E,TURGUT M,PEHLİVAN M,AKAY O,GURKAN E,Paydas S,kahraman s,DEMİRKAN F,KIRKIZLAR O,AKPINAR S,PAMUK G,DEMİR A,ÖZBAŞ H,Sönmez M,GÜLTÜRK M,Salihoglu A,Eşkazan A,AR M,HAYDAROĞLU ŞAHİN H,Öngören Ş,BAŞLAR Z,AYDIN y,YENERE M,Tuzuner N,FERHANOĞLU A,HAZNEDAROĞLU C,ilhan o,Soysal T Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients. Turkish Journal of Hematology. 2013; 30(4): 351 - 358.
IEEE	Sahin F,SAYDAM G,Cömert M,UZ B,YAVUZ A,TURAN E,YÖNAL HİNDİLERDEN İ,atay m,KELTİKLİ E,TURGUT M,PEHLİVAN M,AKAY O,GURKAN E,Paydas S,kahraman s,DEMİRKAN F,KIRKIZLAR O,AKPINAR S,PAMUK G,DEMİR A,ÖZBAŞ H,Sönmez M,GÜLTÜRK M,Salihoglu A,Eşkazan A,AR M,HAYDAROĞLU ŞAHİN H,Öngören Ş,BAŞLAR Z,AYDIN y,YENERE M,Tuzuner N,FERHANOĞLU A,HAZNEDAROĞLU C,ilhan o,Soysal T "Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients." Turkish Journal of Hematology, 30, ss.351 - 358, 2013.
ISNAD	Sahin, Fahri vd. "Turkish chronic myeloid leukemia study: Retrospective sectional analysis of CML patients". Turkish Journal of Hematology 30/4 (2013), 351-358.