The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats

YENİSEY, Çiğdem; KılıçarsLAN, Naciye; PEKTAŞ, Abdulkadir; Gemalmaz, Hakan; Ünsal, Cengiz; Balkaya, Muharrem; ÇULHACI, Nil

The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats

Abdulkadir PEKTAŞ, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Aydın, Türkiye)

Hakan GEMALMAZ, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Aydın, Türkiye)

Muharrem BALKAYA, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Aydın, Türkiye)

Cengiz ÜNSAL, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Aydın, Türkiye)

Çiğdem YENİSEY, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın, Türkiye)

Naciye KILIÇARSLAN, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın, Türkiye)

Nil ÇULHACI (Adnan Menderes Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Aydın, Türkiye)

Türk Üroloji Dergisi/Turkish Journal of Urology

2 0

Yıl: 2014 Cilt: 40 Sayı: 1 Sayfa Aralığı: 46 - 51 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats

Öz:

Objective: Renal ischemia-reperfusion injury may occur due to nephron-sparing surgery in patients witha solitary kidney or restricted renal parenchymas. Prophylactic agents do not always achieve their intendedeffects and may exhibit side effects. The present study was designed to investigate the possible protectiveeffects of lycopene against hypoxia-induced renal damage.Material and methods: Twelve Wistar rats were used in the study. Female Wistar rats were divided intotwo groups of six rats each; the frst group served as the control, and the second group was treated for twodays with oral lycopene (4 mg/kg per day) before surgery. All Wistar rats were subjected to right nephrec-tomy and abdominal aorta clamping for 45 minutes to induce ischemia, followed by 24 hours of reperfusion.Blood samples were collected from all rats twice before surgery and 24-hours after surgery for analysesof serum urea, creatinine, sodium, and potassium levels. Left nephrectomies were performed followingreperfusion. Then histopathological scores were estimated, and malondialdehyde (MDA), catalase (CAT),superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px) levels in renal tissuesamples were measured, and compared between groups.Results: There were no signifcant differences between the control, and the lycopene group with respect topostischemic urea, creatinine, or potassium levels. A signifcant difference between the groups was observedwith respect to postischemic sodium levels (p=0.028). Pathological scores were higher in the control groupthan in the lycopene group (p<0.05). Mean tissue MDA levels in the control group were higher than in thelycopene group (p=0.055). The mean tissue GSH-Px levels were similar in the control ,and lycopene groups.The mean GSH levels in the control group were higher than in the lycopene group (p>0.05). The mean tissueSOD levels were similar in the control, and lycopene groups. The mean CAT levels in the control group werehigher than in the lycopene group (p>0.05).Conclusion: Lycopene may have a protective effect on the short-term biochemical and histopathologicalparameters following renal ischemia/perfusion injury.

Anahtar Kelime:

Konular: Üroloji ve Nefroloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	PEKTAŞ A, Gemalmaz H, Balkaya M, Ünsal C, YENİSEY Ç, KılıçarsLAN N, ÇULHACI N (2014). The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. , 46 - 51.
Chicago	PEKTAŞ Abdulkadir,Gemalmaz Hakan,Balkaya Muharrem,Ünsal Cengiz,YENİSEY Çiğdem,KılıçarsLAN Naciye,ÇULHACI Nil The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. (2014): 46 - 51.
MLA	PEKTAŞ Abdulkadir,Gemalmaz Hakan,Balkaya Muharrem,Ünsal Cengiz,YENİSEY Çiğdem,KılıçarsLAN Naciye,ÇULHACI Nil The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. , 2014, ss.46 - 51.
AMA	PEKTAŞ A,Gemalmaz H,Balkaya M,Ünsal C,YENİSEY Ç,KılıçarsLAN N,ÇULHACI N The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. . 2014; 46 - 51.
Vancouver	PEKTAŞ A,Gemalmaz H,Balkaya M,Ünsal C,YENİSEY Ç,KılıçarsLAN N,ÇULHACI N The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. . 2014; 46 - 51.
IEEE	PEKTAŞ A,Gemalmaz H,Balkaya M,Ünsal C,YENİSEY Ç,KılıçarsLAN N,ÇULHACI N "The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats." , ss.46 - 51, 2014.
ISNAD	PEKTAŞ, Abdulkadir vd. "The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats". (2014), 46-51.

APA	PEKTAŞ A, Gemalmaz H, Balkaya M, Ünsal C, YENİSEY Ç, KılıçarsLAN N, ÇULHACI N (2014). The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. Türk Üroloji Dergisi/Turkish Journal of Urology, 40(1), 46 - 51.
Chicago	PEKTAŞ Abdulkadir,Gemalmaz Hakan,Balkaya Muharrem,Ünsal Cengiz,YENİSEY Çiğdem,KılıçarsLAN Naciye,ÇULHACI Nil The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. Türk Üroloji Dergisi/Turkish Journal of Urology 40, no.1 (2014): 46 - 51.
MLA	PEKTAŞ Abdulkadir,Gemalmaz Hakan,Balkaya Muharrem,Ünsal Cengiz,YENİSEY Çiğdem,KılıçarsLAN Naciye,ÇULHACI Nil The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. Türk Üroloji Dergisi/Turkish Journal of Urology, vol.40, no.1, 2014, ss.46 - 51.
AMA	PEKTAŞ A,Gemalmaz H,Balkaya M,Ünsal C,YENİSEY Ç,KılıçarsLAN N,ÇULHACI N The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. Türk Üroloji Dergisi/Turkish Journal of Urology. 2014; 40(1): 46 - 51.
Vancouver	PEKTAŞ A,Gemalmaz H,Balkaya M,Ünsal C,YENİSEY Ç,KılıçarsLAN N,ÇULHACI N The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats. Türk Üroloji Dergisi/Turkish Journal of Urology. 2014; 40(1): 46 - 51.
IEEE	PEKTAŞ A,Gemalmaz H,Balkaya M,Ünsal C,YENİSEY Ç,KılıçarsLAN N,ÇULHACI N "The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats." Türk Üroloji Dergisi/Turkish Journal of Urology, 40, ss.46 - 51, 2014.
ISNAD	PEKTAŞ, Abdulkadir vd. "The short-term protective efects of lycopene on renal ischemia- reperfusion injury in rats". Türk Üroloji Dergisi/Turkish Journal of Urology 40/1 (2014), 46-51.