Yıl: 2014 Cilt: 40 Sayı: 3 Sayfa Aralığı: 130 - 133 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL

Öz:
Objective: We aimed to determine predictive values of extracapsular extension (ECE) in patients who had un -dergone radical retropubic prostatectomy (RRP) with prostate-specifc antigen (PSA) values below 10 ng/mL.Material and methods: We retrospectively scanned data of 167 patients with PSA values below 10 ng/mL who had undergone radical retropubic prostatectomy (RRP) between April 2004 and August 2011 inour clinic. Age, PSA, PSA ratio, PSA density, digital rectal examination (DRE) fndings, biopsy total Glea -son score, perineural invasion (PNI), and lymphovascular invasion (LVI) were analyzed. Parameters of thegroups with or without extracapsular extension in RRP pathology specimens were compared.Results: The mean age of patients was 66.4±12.3 years. According to histopathological analysis of the spec -imens of RRP of 167 patients, 45 (26.9%) had extracapsular extension (pT3-4) (Group 1); 122 (73.1%) wereconfned to the prostate (pT2) (Group 2). The mean PSA level was high in Group 1 (p=0.114), PSA ratio washigher in Group 2 (p=0.09). PSA density was 0.17 in Group 1 and 0.24 in Group 2 (p=0.03). DRE positivitywas 53.3% and 57.1%, respectively (p=0.71). Biopsy total Gleason score was higher in Group 1 than Group2 with a statistically signifcant difference (p=0.04). A statistically signifcant difference was found betweenthe rates of PNI and LVI (28.9% and 1.63%, respectively) (p=0.002). There was no statistically signifcantdifference between both groups as for surgical margin positivity (p=0.18).Conclusion: In PCa patients with PSA values below 10 ng/mL, PSA density, lymphovascular invasion andbiopsy Gleason total score were statistically signifcant in predicting extracapsular invasion. Therefore,these results must be considered in preoperative evaluation.
Anahtar Kelime:

Konular: Üroloji ve Nefroloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Parker SL, Tong T, Bolden SL. Cancer statistics. Cancer J Clin 1997;47:5. [CrossRef]
  • 2. Andriole GL, Crawford ED, Grubb III RL, Buys SS, Chia D, Church TR. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009;360:1310-9. [CrossRef]
  • 3. Silverberg E, Boring CC, Squires TS. Cancer statistic. Cancer 1990;40:9-26.
  • 4. Catalona WS, Smiths DS, Ratliff TL. Detection of organ-confined prostate cancer is increased through prostate- specific antigen based screening. JAMA 1993;270:948-54. [CrossRef]
  • 5. Mettlin C, Lee F, Drago J. Findings on the detection of early prostate cancer in 2425 men. Cancer 1991;67:2949-58. [CrossRef]
  • 6. Bensalah K, Lotan J, Karam JA, Sheriat SF. New sirculating biomarkers for prostate cancer. Prostate Cancer Prostatic Dis 2008;11:112-20. [CrossRef]
  • 7. D’amico AV, Whittington R, Malkowicz SB. Clinical Utility of the percentage of positive prostate biopsies in defining biochemical outcome after radical prostatectomy for patients with clinically localized prostate cancer. J Clin Oncol 2000;18:1164-72.
  • 8. Partin AW, Kattan MW, Subong EN. Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer: a multi-institutional update. J Am Med Assoc 1997;277:1445-51. [CrossRef]
  • 9. Grossklaus DJ, Coffey CS, Shappell SB. Percent of cancer in biop - sys et predicts pathological findings after prostatectomy. J Urol 2002;167:2032-6. [CrossRef]
  • 10. Walsh PC. Anatomic radical retropubic prostatectomy; in Walsh PC, Retik AB, Vaughan ED Jr., Wein AJ (eds): Campbell’s Urology 1998, ed 7, Philadelphia, vol 3, 2565-88.
  • 11. Seaman EK, Whang IS, Cooner W, Olsson CA, Benson MC. Predictive value of prostate-specific antigen density for the presence of micrometastatic carcinoma of the prostate. Urology 1994;43:645-8. [CrossRef]
  • 12. Chang JS, Choi H, Chang YS, Kim JB, Oh MM, Moon DG, et al. Prostate-specific antigen density as a powerful predictor of extracapsular extension and positive surgical margin in radical prostatectomy patients with prostate-specific antigen levels of less than 10 ng/ml. Korean J Urol 2011;52:809-14. [CrossRef]
  • 13. Ishida M, Nakashima J, Hashiguchi A, Mizuno R, Shinoda K, Kikuchi E, et al. Are predictive models for cancer volume clinically useful in localized prostate cancer? Int J Urol 2009;16:936-40. [CrossRef]
  • 14. Stamatakis L, Siddiqui MM, Nix JW, Logan J, Rais-Bahrami S, Walton-Diaz A, et al. Accuracy of multiparametric magnetic resonance imaging in confirming eligibility for active surveillance for men with prostate cancer. Cancer 2013;119:3359-66. [CrossRef]
  • 15. Perrotti M, Pantuck A, Rabbani F. Review of staging modalities in clini- cally localized prostate cancer. Urology 1999;54:208-14. [CrossRef]
  • 16. Görgel SN, Şefik E, Balcı U, Girgin MC, Dinçel Ç. The relation - ship between prostate size, patient age and prognostic factors in patients with prostate biopsy cancer detected. Turkish Journal of Urology 2012;38:121-5. [CrossRef]
  • 17. Noldus J, Stamey TA. Limitations of serum prostate specific antigen in predicting peripheral and transition zone cancer volumes as measured by correlation coefficients. J Urol 1996;155:232-7. [CrossRef]
  • 18. Bostwick DG. Staging prostate cancer: Current methods and limi- tations. Eur Urol 1997;32:2-14.
  • 19. Günlüsoy B, Zeyrek N, Arslan M, Değirmenci T, Minareci S, Ayder AR. Preoperative prediction of surgical margin status in patients with localized prostat cancer treated by radical prostatectomy. Turkish Journal of Urology 2006;32:30-6.
  • 20. Masieri L, Minervini A, Vittori G, Lanciotti M, Lanzi F, Lapini A, et al. The role of free to total PSA ratio in prediction of extracapsular tumor extension and biochemical recurrence after radical prostatectomy in patients with PSA between 4 and 10 ng/ml. Int Urol and Neph 2012;44:1031-8. [CrossRef]
APA Sertkaya Z, öztürk m, Koca O, Gunes M, KARAMAN M (2014). Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. , 130 - 133.
Chicago Sertkaya Zülfü,öztürk metin,Koca Orhan,Gunes Mustafa,KARAMAN Muhammet İhsan Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. (2014): 130 - 133.
MLA Sertkaya Zülfü,öztürk metin,Koca Orhan,Gunes Mustafa,KARAMAN Muhammet İhsan Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. , 2014, ss.130 - 133.
AMA Sertkaya Z,öztürk m,Koca O,Gunes M,KARAMAN M Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. . 2014; 130 - 133.
Vancouver Sertkaya Z,öztürk m,Koca O,Gunes M,KARAMAN M Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. . 2014; 130 - 133.
IEEE Sertkaya Z,öztürk m,Koca O,Gunes M,KARAMAN M "Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL." , ss.130 - 133, 2014.
ISNAD Sertkaya, Zülfü vd. "Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL". (2014), 130-133.
APA Sertkaya Z, öztürk m, Koca O, Gunes M, KARAMAN M (2014). Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. Türk Üroloji Dergisi/Turkish Journal of Urology, 40(3), 130 - 133.
Chicago Sertkaya Zülfü,öztürk metin,Koca Orhan,Gunes Mustafa,KARAMAN Muhammet İhsan Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. Türk Üroloji Dergisi/Turkish Journal of Urology 40, no.3 (2014): 130 - 133.
MLA Sertkaya Zülfü,öztürk metin,Koca Orhan,Gunes Mustafa,KARAMAN Muhammet İhsan Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. Türk Üroloji Dergisi/Turkish Journal of Urology, vol.40, no.3, 2014, ss.130 - 133.
AMA Sertkaya Z,öztürk m,Koca O,Gunes M,KARAMAN M Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. Türk Üroloji Dergisi/Turkish Journal of Urology. 2014; 40(3): 130 - 133.
Vancouver Sertkaya Z,öztürk m,Koca O,Gunes M,KARAMAN M Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL. Türk Üroloji Dergisi/Turkish Journal of Urology. 2014; 40(3): 130 - 133.
IEEE Sertkaya Z,öztürk m,Koca O,Gunes M,KARAMAN M "Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL." Türk Üroloji Dergisi/Turkish Journal of Urology, 40, ss.130 - 133, 2014.
ISNAD Sertkaya, Zülfü vd. "Predictive values for extracapsular extension in prostate cancer patients with PSA values below 10 ng/mL". Türk Üroloji Dergisi/Turkish Journal of Urology 40/3 (2014), 130-133.