Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor

Musa Özgür ÖZYİĞİT, (Uludağ Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Bursa, Türkiye)
Deniz NAK, (Uludağ Üniversitesi, Veteriner Fakültesi, Doğum ve Jinekoloji Anabilim Dalı, Bursa, Türkiye)
Hasan AKŞİT, (Balıkesir Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Balıkesir, Türkiye)
Sevda ÖZTÜRKOĞLU İNAN, (Uludağ Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Bursa, Türkiye)
Gözde ŞİMŞEK, (Uludağ Üniversitesi, Veteriner Fakültesi, Doğum ve Jinekoloji Anabilim Dalı, Bursa, Türkiye)
Ender UZABACI, (Uludağ Üniversitesi, Veteriner Fakültesi, Biyoistatistik Anabilim Dalı, Bursa, Türkiye)
Yavuz NAK, (Uludağ Üniversitesi, Veteriner Fakültesi, Doğum ve Jinekoloji Anabilim Dalı, Bursa, Türkiye)
Kamil SEYREK (Balıkesir Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Balıkesir, Türkiye)
Turkish Journal of Veterinary and Animal Sciences
3 0
Yıl: 2014 Cilt: 38 Sayı: 3 Sayfa Aralığı: 331 - 338 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor

Öz:
Vincristine sulfate is one of the most efective chemical agents used in canine transmissible venereal tumor (CTVT)chemotherapy. Its therapeutic efectiveness is pronounced and signifcant at the beginning of treatment. Te present study was designedto investigate vincristine sulfate treatment and the relationship between CTVT tumor regression and apoptosis [estimated by TdT-mediated dUTP-biotin nick end labeling (TUNEL)], galectin-3 (H-160), Bcl-2 (N-9), and lectin [EEL (B-135), GSL I (L-1100), andRCA I (BA-0084)] expression using immunohistochemical staining in 20 bitches with naturally occurring CTVTs. Evaluation wassemiquantitatively performed by HSCORE values using light microscopy. All observed staining was intracytoplasmic and increasedendothelial staining was noted with the Bcl-2 marker in tumor vessels. Apoptosis, TUNEL, and lectin scoring was higher in vincristinesulfate-treated tumors than in untreated tumors, while expression of antiapoptotic factors galectin-3 and Bcl-2 were lower in treatedthan in untreated CTVTs. Tese results show that galectin-3, Bcl-2, and lectins (EEL, GSL-1, and RCA-1) are suitable indicators/markersfor CTVT tumor regression afer treatment with vincristine sulfate.
Anahtar Kelime:

Konular: Ziraat Mühendisliği
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ÖZYİĞİT M, Nak D, AKSIT H, ÖZTÜRKOĞLU İNAN S, ŞİMŞEK G, Uzabacı E, Nak Y, SEYREK K (2014). Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. , 331 - 338.
Chicago ÖZYİĞİT Musa Özgür,Nak Deniz,AKSIT HASAN,ÖZTÜRKOĞLU İNAN Sevda,ŞİMŞEK Gözde,Uzabacı Ender,Nak Yavuz,SEYREK Kamil Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. (2014): 331 - 338.
MLA ÖZYİĞİT Musa Özgür,Nak Deniz,AKSIT HASAN,ÖZTÜRKOĞLU İNAN Sevda,ŞİMŞEK Gözde,Uzabacı Ender,Nak Yavuz,SEYREK Kamil Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. , 2014, ss.331 - 338.
AMA ÖZYİĞİT M,Nak D,AKSIT H,ÖZTÜRKOĞLU İNAN S,ŞİMŞEK G,Uzabacı E,Nak Y,SEYREK K Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. . 2014; 331 - 338.
Vancouver ÖZYİĞİT M,Nak D,AKSIT H,ÖZTÜRKOĞLU İNAN S,ŞİMŞEK G,Uzabacı E,Nak Y,SEYREK K Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. . 2014; 331 - 338.
IEEE ÖZYİĞİT M,Nak D,AKSIT H,ÖZTÜRKOĞLU İNAN S,ŞİMŞEK G,Uzabacı E,Nak Y,SEYREK K "Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor." , ss.331 - 338, 2014.
ISNAD ÖZYİĞİT, Musa Özgür vd. "Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor". (2014), 331-338.
APA ÖZYİĞİT M, Nak D, AKSIT H, ÖZTÜRKOĞLU İNAN S, ŞİMŞEK G, Uzabacı E, Nak Y, SEYREK K (2014). Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. Turkish Journal of Veterinary and Animal Sciences, 38(3), 331 - 338.
Chicago ÖZYİĞİT Musa Özgür,Nak Deniz,AKSIT HASAN,ÖZTÜRKOĞLU İNAN Sevda,ŞİMŞEK Gözde,Uzabacı Ender,Nak Yavuz,SEYREK Kamil Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. Turkish Journal of Veterinary and Animal Sciences 38, no.3 (2014): 331 - 338.
MLA ÖZYİĞİT Musa Özgür,Nak Deniz,AKSIT HASAN,ÖZTÜRKOĞLU İNAN Sevda,ŞİMŞEK Gözde,Uzabacı Ender,Nak Yavuz,SEYREK Kamil Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. Turkish Journal of Veterinary and Animal Sciences, vol.38, no.3, 2014, ss.331 - 338.
AMA ÖZYİĞİT M,Nak D,AKSIT H,ÖZTÜRKOĞLU İNAN S,ŞİMŞEK G,Uzabacı E,Nak Y,SEYREK K Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. Turkish Journal of Veterinary and Animal Sciences. 2014; 38(3): 331 - 338.
Vancouver ÖZYİĞİT M,Nak D,AKSIT H,ÖZTÜRKOĞLU İNAN S,ŞİMŞEK G,Uzabacı E,Nak Y,SEYREK K Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor. Turkish Journal of Veterinary and Animal Sciences. 2014; 38(3): 331 - 338.
IEEE ÖZYİĞİT M,Nak D,AKSIT H,ÖZTÜRKOĞLU İNAN S,ŞİMŞEK G,Uzabacı E,Nak Y,SEYREK K "Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor." Turkish Journal of Veterinary and Animal Sciences, 38, ss.331 - 338, 2014.
ISNAD ÖZYİĞİT, Musa Özgür vd. "Te efects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specifc for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor". Turkish Journal of Veterinary and Animal Sciences 38/3 (2014), 331-338.
Sayfa Oluşturulma Tarihi
22-04-2024 20:37

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