Yıl: 2014 Cilt: 11 Sayı: 3 Sayfa Aralığı: 184 - 191 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effect of antiresorptive treatment on osteopontin values in osteoporosis

Öz:
Amaç: Yüksek osteopontin (OPN) seviyelerinin kemik rezorpsiyonu ile ilişkili olduğu bildirilmiştir.Osteoporozda (OP) anabolik etki amacıyla uygulanan parathormonun, OPN düzeylerinde düşmeye nedenolduğu tespit edilmiştir. Bu çalışmanın amacı OP tedavisi için antirezorptif tedavi alan hastalarda OPNdüzeylerinin değerlendirilmesidir. Materyal ve metot: Çalışmamıza, 45-70 yaş arası, en az bir yıldır menopoza girmiş, OP tanısı alan 90 kadınhasta ve 80 sağlıklı kadın gönüllü dahil edildi. OP hastaları antirezorptif kullanan (60 hasta;15 bifosfonat, 15kalsitonin, 15 raloksifen, 15 strontium ranelate kullanan hasta) ve kullanmayanlar (30 hasta) olmak üzere ikigruba ayrıldı. Hastalara KMY ölçümü, DEXA (Dual Enerji X-Ray Absorbsiyometri) yöntemi ile yapıldı.Plazma OPN konsantrasyonu enzyme-link immunosorbent assay (ELISA) methodu kullanılarak hesaplandı.Bulgular: Antirezorptif kullanan OP grubunda OPN düzeyleri, antirezorptif almayan OP grubuna ve OPolmayan sağlıklı kontrol grubuna göre istatistiksel olarak anlamlı düzeyde daha düşüktü (sırasıyla p<0.001ve p=0.008). OP olmayan sağlıklı kontrollerle ilaç kullanmayan OP grubunun OPN değerleri arasındaistatistiksel olarak anlamlı bir fark yoktu (p>0.05).Sonuç: Sonuçlarımızın, antirezorptif tedavinin OPN seviyelerinde düşmeye neden olduğunu göstermesi,bize OPN'nin, antirezorptif tedavinin takibinde bir biomarker olarak kullanılabileceğini düşündürdü.
Anahtar Kelime:

Konular: Cerrahi

Osteoporozda antirezorptif tedavinin osteopontin değerleri üzerine etkisi

Öz:
Background: An association between increased OPN levels and lowered bone mineral density (BMD) withincreased bone turnover markers was established. The aim of this study is to evaluate the levels of OPN in OPpatients who receive antiresorptive treatment (ART).Methods: Ninety female OP patients in the post-menopausal period for at least a year in the age range of 45 -70 years and 80 healthy female volunteers were included in the study. OP patients were divided into 2subgroups as ART-receiving (60 patients; bisphosphonate (15), calcitonin (15), raloxifene (15), strontiumranelate (15) and ART non-receiving (30 patients). Bone mineral density was analyzed using the dual energyX-ray absorptiometry method. The plasma OPN concentration was calculated using the enzyme-linkimmunosorbent assay method.Result s : OPN levels were significantly lower in antiresorptive-receiving OP patients compared to OPpatients who did not receive ART and compared to the control group (p<0.001 and p=0.008 respectively).There was no meaningful difference in terms of the OPN values between the controls and OP patients whodid not receive ART (p>0.05).Conclusions: Lowered OPN levels in ART-receiving OP patients suggest that OPN could be used as abiomarker in ART follow-up in OP.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA KOCA I, GÖGEBAKAN B, İĞCİ Y, IŞIK M, BOYACİ A, TUTOĞLU A, GEYİK E, İĞCİ M (2014). The effect of antiresorptive treatment on osteopontin values in osteoporosis. , 184 - 191.
Chicago KOCA IRFAN,GÖGEBAKAN Bülent,İĞCİ Yusuf Ziya,IŞIK MUSTAFA,BOYACİ Ahmet,TUTOĞLU Ahmet,GEYİK Esra,İĞCİ Mehri The effect of antiresorptive treatment on osteopontin values in osteoporosis. (2014): 184 - 191.
MLA KOCA IRFAN,GÖGEBAKAN Bülent,İĞCİ Yusuf Ziya,IŞIK MUSTAFA,BOYACİ Ahmet,TUTOĞLU Ahmet,GEYİK Esra,İĞCİ Mehri The effect of antiresorptive treatment on osteopontin values in osteoporosis. , 2014, ss.184 - 191.
AMA KOCA I,GÖGEBAKAN B,İĞCİ Y,IŞIK M,BOYACİ A,TUTOĞLU A,GEYİK E,İĞCİ M The effect of antiresorptive treatment on osteopontin values in osteoporosis. . 2014; 184 - 191.
Vancouver KOCA I,GÖGEBAKAN B,İĞCİ Y,IŞIK M,BOYACİ A,TUTOĞLU A,GEYİK E,İĞCİ M The effect of antiresorptive treatment on osteopontin values in osteoporosis. . 2014; 184 - 191.
IEEE KOCA I,GÖGEBAKAN B,İĞCİ Y,IŞIK M,BOYACİ A,TUTOĞLU A,GEYİK E,İĞCİ M "The effect of antiresorptive treatment on osteopontin values in osteoporosis." , ss.184 - 191, 2014.
ISNAD KOCA, IRFAN vd. "The effect of antiresorptive treatment on osteopontin values in osteoporosis". (2014), 184-191.
APA KOCA I, GÖGEBAKAN B, İĞCİ Y, IŞIK M, BOYACİ A, TUTOĞLU A, GEYİK E, İĞCİ M (2014). The effect of antiresorptive treatment on osteopontin values in osteoporosis. Harran Üniversitesi Tıp Fakültesi Dergisi, 11(3), 184 - 191.
Chicago KOCA IRFAN,GÖGEBAKAN Bülent,İĞCİ Yusuf Ziya,IŞIK MUSTAFA,BOYACİ Ahmet,TUTOĞLU Ahmet,GEYİK Esra,İĞCİ Mehri The effect of antiresorptive treatment on osteopontin values in osteoporosis. Harran Üniversitesi Tıp Fakültesi Dergisi 11, no.3 (2014): 184 - 191.
MLA KOCA IRFAN,GÖGEBAKAN Bülent,İĞCİ Yusuf Ziya,IŞIK MUSTAFA,BOYACİ Ahmet,TUTOĞLU Ahmet,GEYİK Esra,İĞCİ Mehri The effect of antiresorptive treatment on osteopontin values in osteoporosis. Harran Üniversitesi Tıp Fakültesi Dergisi, vol.11, no.3, 2014, ss.184 - 191.
AMA KOCA I,GÖGEBAKAN B,İĞCİ Y,IŞIK M,BOYACİ A,TUTOĞLU A,GEYİK E,İĞCİ M The effect of antiresorptive treatment on osteopontin values in osteoporosis. Harran Üniversitesi Tıp Fakültesi Dergisi. 2014; 11(3): 184 - 191.
Vancouver KOCA I,GÖGEBAKAN B,İĞCİ Y,IŞIK M,BOYACİ A,TUTOĞLU A,GEYİK E,İĞCİ M The effect of antiresorptive treatment on osteopontin values in osteoporosis. Harran Üniversitesi Tıp Fakültesi Dergisi. 2014; 11(3): 184 - 191.
IEEE KOCA I,GÖGEBAKAN B,İĞCİ Y,IŞIK M,BOYACİ A,TUTOĞLU A,GEYİK E,İĞCİ M "The effect of antiresorptive treatment on osteopontin values in osteoporosis." Harran Üniversitesi Tıp Fakültesi Dergisi, 11, ss.184 - 191, 2014.
ISNAD KOCA, IRFAN vd. "The effect of antiresorptive treatment on osteopontin values in osteoporosis". Harran Üniversitesi Tıp Fakültesi Dergisi 11/3 (2014), 184-191.